Journal ArticleDOI
A Simple, Efficient and Green Procedure for the Knoevenagel Condensation of Aldehydes with N-Methylpiperazine at Room Temperature under Solvent-Free Conditions
Chhanda Mukhopadhyay,Arup Datta +1 more
TLDR
In this article, Knoevenagel condensation of aromatic, aliphatic, and heteroaromatic aldehydes with active methylene compounds such as ethylcyanoacetate, malononitrile, and cyanoacetamide proceed very smoothly at room temperature by simply mixing the ingredients together under solvent-free conditions.About:
This article is published in Synthetic Communications.The article was published on 2008-08-18. It has received 35 citations till now. The article focuses on the topics: Knoevenagel condensation & Malononitrile.read more
Citations
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Journal ArticleDOI
Nano‐Fe3O4 Encapsulated‐Silica Particles Bearing 3‐Aminopropyl Group as a Magnetically Separable Catalyst for Efficient Knoevenagel Condensation of Aromatic Aldehydes with Active Methylene Compounds
TL;DR: In this article, the condensation of aromatic aldehydes with active methylene compounds such as malononitrile, ethylcyanoacetate, benzimidazol-2-acetonitrile and benzothiazole-2 -acetitrile with nano-Fe3O4 encapsulated-silica particles supported primary amine is described.
Journal ArticleDOI
Efficient Approach to Pure Entacapone and Related Compounds
G. Srikanth,Uttam Kumar Ray,D. V. N. Srinivas Rao,P. Badarinadh Gupta,P. Lavanya,Aminul Islam +5 more
TL;DR: A new and efficient process through a new intermediate, (2E)-2-cyano-3-(3,4-dihydroxy-5-nirtrophenyl)prop-2-enoic acid 15, has been described for preparing substantially pure entacapone 1 as mentioned in this paper.
Journal ArticleDOI
Melamine as a Green and Reusable Catalyst for Knoevenagel Condensation at Room Temperature Under Solvent-Free Conditions
Xian-Cao Yang,Hong Jiang,Wen Ye +2 more
TL;DR: In this paper, a rapid, efficient and eco-friendly protocol was developed for the Knoevenagel condensation of active methylene compounds such as malononitrile or ethyl cyanoacetate with aldehydes with good to excellent yields at room temperature without solvent.
Journal ArticleDOI
Arylboronic acids inhibit P2X7 receptor function and the acute inflammatory response
Robson Xavier Faria,Noemi de Jesus Hiller,Juliana Pimenta Salles,Jackson A. L. C. Resende,Roberta Tosta Diogo,Natalia Lidmar von Ranke,Natalia Lidmar von Ranke,Murilo Lamim Bello,Carlos Rangel Rodrigues,Helena Carla Castro,Daniela de Luna Martins +10 more
TL;DR: Results indicate that the boronic acid derivative NO-01 shows the lead compound characteristics to be used as a scaffold structure to the development of new P2X7R inhibitors with anti-inflammatory action.
Journal ArticleDOI
Basic polymerized imidazolide-based ionic liquid: an efficient catalyst for aqueous Knoevenagel condensation
Libing Ding,Hansheng Li,Yaping Zhang,Zhang Kun,Hong Yuan,Qin Wu,Yun Zhao,Qingze Jiao,Daxin Shi +8 more
TL;DR: In this article, a novel basic polymerized ionic liquid (BPIL) was synthesized and characterized by Fourier transform infrared (FT-IR), nuclear magnetic resonance (NMR) and electron spray ionization mass spectrometry (ESI-MS).
References
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Journal ArticleDOI
Solvent‐Free Organic Synthesis
Koichi Tanaka,Fumio Toda +1 more
TL;DR: This paper presents a new approach to solvent-free organic synthesis called “Solvent-free synthesis with real-time stoichiometry” that combines high-performance liquid chromatography and high-tech electronics.
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Solvent-free organic synthesis
Koichi Tanaka,Fumio Toda +1 more
TL;DR: In this paper, the authors proposed a Solvent Free Organic Synthesis (SOS) method for organic synthesis, which is a state-of-the-art method for solvent-free organic synthesis.
Journal ArticleDOI
Montmorillonite KSF as an Inorganic, Water Stable, and Reusable Catalyst for the Knoevenagel Synthesis of Coumarin-3-carboxylic Acids.
Journal ArticleDOI
Zinc chloride as a new catalyst for knoevenagel condensation
TL;DR: In this article, the knoevenagel condensation of carbonyl substrates with acidic methylene reagents proceeds smoothly in presence of zinc chloride, without the need for solvent, to produce products of good purity in high yield.
Journal Article
Ionic liquid as catalyst and reaction medium – a simple, efficient and green procedure for Knoevenagel condensation of aliphatic and aromatic carbonyl compounds using a task-specific basic ionic liquid
Brindaban C. Ranu,Ranjan Jana +1 more
TL;DR: In this article, the authors proposed a methodology for condensation of aliphatic aldehyde with diethyl malonate, which is not very easy to achieve by conventional reagents, and was not addressed adequately in literature.
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Ionic Liquid as Catalyst and Reaction Medium – A Simple, Efficient and Green Procedure for Knoevenagel Condensation of Aliphatic and Aromatic Carbonyl Compounds Using a Task‐Specific Basic Ionic Liquid
Brindaban C. Ranu,Ranjan Jana +1 more