Journal ArticleDOI
A study of VEGF and its receptors in two rat models of proteinuria.
John Kanellis,Vicki Levidiotis,Tiffany Khong,Alison J. Cox,Steven A. Stacker,Richard E. Gilbert,Mark E. Cooper,David A. Power +7 more
Reads0
Chats0
TLDR
The expression of V EGF and its receptors is significantly increased in the PHN and PAN rat models of proteinuria suggesting a role for VEGF in the disease process.Abstract:
Background: The high level of expression of vascular endothelial growth factor (VEGF) in normal podocyte foot processes suggests that VEGF has an important role in maintaining normaread more
Citations
More filters
Journal ArticleDOI
Experimental membranous nephropathy redux
TL;DR: This review revisits HN and focuses on areas of substantial progress in recent years, including identifying key steps in complement activation, the cellular signaling pathways, and the targets that will facilitate therapeutic intervention in reversing GEC injury in human MN.
Journal ArticleDOI
Blockade of VEGF accelerates proteinuria, via decrease in nephrin expression in rat crescentic glomerulonephritis
Akinori Hara,Takashi Wada,Kengo Furuichi,Norihiko Sakai,Hiroshi Kawachi,Fuijo Shimizu,M. Shibuya,Koji Matsushima,Hitoshi Yokoyama,Kensuke Egashira,Shuichi Kaneko +10 more
TL;DR: It is hypothesized that VEGF may be beneficial for maintaining glomerular filtration barrier and vascular network in rats with progressive glomerulonephritis and may play a role in maintaining the podocyte function as well as renal vasculature, thereby protecting glomeruli and interstitium from progressive renal insults.
Journal ArticleDOI
VEGF –460 genotype plays an important role in progression to chronic kidney disease stage 5
TL;DR: An association between the VEGF -460 polymorphism and progression to CKD stage 5 is demonstrated, indicating a role for TGF-beta1 in chronic kidney disease.
Journal ArticleDOI
GIV/Girdin Links Vascular Endothelial Growth Factor Signaling to Akt Survival Signaling in Podocytes Independent of Nephrin
TL;DR: It is shown that Gα-interacting, vesicle-associated protein (GIV)/girdin mediates VEGF receptor 2 (VEGFR2) signaling and compensates for nephrin loss in podocyte survival and may represent a novel target for therapeutic intervention in the nephrotic syndrome and other proteinuric diseases.
Journal ArticleDOI
VEGF regulates TRPC6 channels in podocytes
Florian Thilo,Ying Liu,Ying Liu,Ying Liu,Christoph Loddenkemper,Christoph Loddenkemper,Ralf Schuelein,Antje Schmidt,Zengcheng Yan,Zhiming Zhu,Andreas Zakrzewicz,Maik Gollasch,Martin Tepel,Martin Tepel +13 more
TL;DR: The effects of VEGF165 were dose dependent and could be blocked by phosphoinositide-3-kinase inhibitors, and there was a significant association between VEGFR-2 mRNA and TRPC6 mRNA (n = 48; r(2) = 0.585; P < 0.0001) in human renal cortex.
References
More filters
Journal ArticleDOI
Vascular endothelial growth factor is a secreted angiogenic mitogen
TL;DR: DNA sequencing suggests the existence of several molecular species of VEGF, a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo.
Journal ArticleDOI
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
Donald R. Senger,Stephen J. Galli,Ann M. Dvorak,Carole A. Perruzzi,V. Susan Harvey,Harold F. Dvorak +5 more
TL;DR: Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability, and this activity is secreted by these tumor cells and a variety of other tumor cell lines in vitro.
Journal ArticleDOI
Vascular permeability factor, an endothelial cell mitogen related to PDGF
Pamela Jean Keck,Scott D. Hauser,Gwen G. Krivi,Kim Sanzo,Thomas G. Warren,Joseph Feder,Daniel T. Connolly +6 more
TL;DR: The cDNA sequence of VPF from human U937 cells was shown to code for a 189-amino acid polypeptide that is similar in structure to the B chain of platelet-derived growth factor (PD GF-B) and other PDGF-B-related proteins, suggesting that VPF appears to be related to the PDGF/v-sis family of proteins.
Journal ArticleDOI
Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway REQUIREMENT FOR Flk-1/KDR ACTIVATION
Hans-Peter Gerber,Amy McMurtrey,Joe Kowalski,Minhong Yan,Bruce Keyt,Vishva M. Dixit,Napoleone Ferrara +6 more
TL;DR: The Flk-1/KDR receptor and the PI3-kinase/Akt signal transduction pathway are identified as crucial elements in the processes leading to endothelial cell survival induced by VEGF, and inhibition of apoptosis may represent a major aspect of the regulatory activity of V EGF on the vascular endothelium.
Journal ArticleDOI
Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.
TL;DR: Neither the receptor-associated activity of phosphatidylinositol 3'-kinase nor tyrosine phosphorylation of phospholipase C-gamma were affected by stimulation of Flt1 or KDR expressing cells, and phosphorylated of GTPase activating protein was only slightly increased.