Accidental virulence, cryptic pathogenesis, martians, lost hosts, and the pathogenicity of environmental microbes.
Reads0
Chats0
TLDR
The germ theory of disease was proposed in this work as a guide to the selection of hosts for virulent microbes and the role of immune checkpoints in microbial pathogenesis.Abstract:
Why do only certain microbes have the capacity to be virulent, and why are certain microbes virulent only in certain hosts? These fundamental questions have shaped and directed the thinking of microbiologists and the field of microbial pathogenesis since the germ theory of disease was proposed inread more
Citations
More filters
Book ChapterDOI
The capsule of the fungal pathogen Cryptococcus neoformans
Oscar Zaragoza,Marcio L. Rodrigues,Magdia De Jesus,Susana Frases,Ekaterina Dadachova,Arturo Casadevall +5 more
TL;DR: An update on the current knowledge of the C. neoformans capsule is provided, covering aspects related to its structure, synthesis and particularly, its role as a virulence factor.
Journal ArticleDOI
Cryptococcus neoformans and Cryptococcus gattii, the Etiologic Agents of Cryptococcosis
Kyung J. Kwon-Chung,James A. Fraser,Tamara L. Doering,Zhuo Wang,Guilhem Janbon,Alexander Idnurm,Yong Sun Bahn +6 more
TL;DR: Topics focused on in this article include species description, pathogenesis, life cycle, capsule, and stress response, which serve to highlight the specializations in virulence that have occurred in this unique encapsulated melanin-forming yeast that causes global deaths estimated at more than 600,000 annually.
Journal ArticleDOI
Aspergillus Fumigatus Morphology and Dynamic Host Interactions
TL;DR: This Review describes how A. fumigatus adapts to environmental change, the mechanisms of host defence, and the current knowledge of the interplay between the host immune response and the fungus.
Journal ArticleDOI
Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism.
TL;DR: It is reported that exposure of C. albicans to the mammalian gut triggers a developmental switch, driven by the Wor1 transcription factor, to a commensal cell type, and the resulting GUT cells differ morphologically and functionally from previously defined cell types, and express a transcriptome that is optimized for the digestive tract.
Journal ArticleDOI
IL-22 defines a novel immune pathway of antifungal resistance
A. De Luca,Teresa Zelante,Carmen D'Angelo,S. Zagarella,Francesca Fallarino,Antonio Spreca,Rossana G. Iannitti,Pierluigi Bonifazi,Jean-Christophe Renauld,Francesco Bistoni,Paolo Puccetti,Luigina Romani +11 more
TL;DR: Evidence is provided that IL-22, which is also produced by Th17 cells, has a critical, first-line defense in candidiasis by controlling the growth of infecting yeasts as well as by contributing to the host's epithelial integrity in the absence of acquired Th1-type immunity.
References
More filters
Widespread amphibian extinctions from epidemic disease driven by global
Luis A. Coloma,Jamie A. Consuegra,Michael P. L. Fogden,Pru N Foster,Enrique La Marca,Karen L. Masters,Robert Puschendorf,Santiago R. Ron,Christopher J. Still,Bruce E. Young +9 more
TL;DR: In this article, a recent mass extinction associated with pathogen outbreaks is tied to global warming, and the timing of losses in relation to changes in sea surface and air temperatures is analyzed.
Journal ArticleDOI
Widespread amphibian extinctions from epidemic disease driven by global warming
J. Alan Pounds,Martín R. Bustamante,Luis A. Coloma,Jamie A. Consuegra,Michael P. L. Fogden,Pru N Foster,Pru N Foster,Enrique La Marca,Karen L. Masters,Andrés Merino-Viteri,Robert Puschendorf,Santiago R. Ron,Santiago R. Ron,G. Arturo Sánchez-Azofeifa,Christopher J. Still,Bruce E. Young +15 more
TL;DR: It is shown that a recent mass extinction associated with pathogen outbreaks is tied to global warming, and it is proposed that temperatures at many highland localities are shifting towards the growth optimum of Batrachochytrium, thus encouraging outbreaks.
Journal ArticleDOI
Pathogenesis of infections due to coagulasenegative staphylococci
TL;DR: The most important aspects of the pathogenic potential of S saprophyticus, S lugdunensis, and S schleiferi are described, although, compared with S epidermidis, much less is known in these species concerning their virulence factors.
Journal ArticleDOI
Molecular Koch's Postulates Applied to Microbial Pathogenicity
TL;DR: It is presented here that a form of molecular Koch's postulates is needed when examining the potential role of genes and their products in the pathogenesis of infection and disease.
Journal Article
Causation and Disease: The Henle-Koch Postulates Revisited
TL;DR: The Henle-Koch postulates are reviewed in terms of their full validity in Koch's day and in light of subsequent developments, and a set of guidelines for both acute infectious and chronic diseases is presented.