Acinetobacter baumannii: Human infections, factors contributing to pathogenesis and animal models
TLDR
This review summarizes the characteristics of A. baumannii that contribute to its pathogenesis, with a focus on motility, adherence, biofilm formation, and iron acquisition.Abstract:
Acinetobacter baumannii has emerged as a medically important pathogen because of the increasing number of infections produced by this organism over the preceding three decades and the global spread of strains with resistance to multiple antibiotic classes. In spite of its clinical relevance, until recently, there have been few studies addressing the factors that contribute to the pathogenesis of this organism. The availability of complete genome sequences, molecular tools for manipulating the bacterial genome, and animal models of infection have begun to facilitate the identification of factors that play a role in A. baumannii persistence and infection. This review summarizes the characteristics of A. baumannii that contribute to its pathogenesis, with a focus on motility, adherence, biofilm formation, and iron acquisition. In addition, the virulence factors that have been identified to date, which include the outer membrane protein OmpA, phospholipases, membrane polysaccharide components, penicillin-binding proteins, and outer membrane vesicles, are discussed. Animal models systems that have been developed during the last 15 years for the study of A. baumannii infection are overviewed, and the recent use of these models to identify factors involved in virulence and pathogenesis is highlighted.read more
Citations
More filters
Journal ArticleDOI
Characterization of a highly virulent and antimicrobial-resistant Acinetobacter baumannii strain isolated from diseased chicks in China.
Dong Liu,Zeng-Shan Liu,Pan Hu,Qi Hui,Bao-Quan Fu,Shi-Ying Lu,Yan-Song Li,De-Ying Zou,Zhao-Hui Li,Dong-Ming Yan,Yan-Xia Ding,Yuan-Yuan Zhang,Yu Zhou,Nan-Nan Liu,Hong-Lin Ren +14 more
TL;DR: An Acinetobacter baumannii strain, CCGGD201101, isolated from diseased chicks in the Jilin Province of China had both virulence enhancement and antibiotic resistance characteristics, which are beneficial for A. baumANNii survival under adverse conditions and enhance fitness and invasiveness in the host.
Journal ArticleDOI
Transcriptome Profiling of Lung Innate Immune Responses Potentially Associated With the Pathogenesis of Acinetobacter baumannii Acute Lethal Pneumonia.
TL;DR: Insight is provided into the pathogenesis of lethal A. baumannii lung infection supported by high bacterial burdens, severe inflammatory cells infiltration and lung damage, and immune response of innate immune cells headed by neutrophils.
Journal ArticleDOI
Occurrence of blaTEM and blaCTXM Genes and Biofilm-Forming Ability among Clinical Isolates of Pseudomonas aeruginosa and Acinetobacter baumannii in Yaoundé, Cameroon
Estelle Longla Madaha,Hortense Kamga Gonsu,Rhoda Nsen Bughe,Marie Christine Fonkoua,Collins Njie Ateba,Wilfred Fon Mbacham +5 more
TL;DR: The findings reveal the occurrence of both virulence and drug-resistant determinants in clinical PSA and ACB isolates from patients in health care settings in Yaoundé, Cameroon, thus suggesting their role in the pathological conditions in patients.
Journal ArticleDOI
New STs in multidrug-resistant Acinetobacter baumannii harbouring β-lactamases encoding genes isolated from Brazilian soils.
TL;DR: The resistance profile, presence of β‐lactamases encoding genes and the clonal relationships in Acinetobacter baumannii isolated from Brazilian soils are investigated.
Journal ArticleDOI
Molecular typing of multi-drug resistant Acinetobacter baumannii isolates from clinical and environmental specimens in three Iranian hospitals by pulsed field gel electrophoresis.
Ali Mohammadi Bardbari,Parviz Mohajeri,Mohammad Reza Arabestani,Manoochehr Karami,Fariba Keramat,Saba Asadollahi,Amir Khodavirdipour,Mohammad Yousef Alikhani +7 more
TL;DR: The results show that there is a close relationship between environmental and clinical isolates of A. baumannii and there was no relationship between biofilm formation and antibiotic resistance patterns with PFGE pulsotypes.
References
More filters
Journal ArticleDOI
Bacterial biofilms : A common cause of persistent infections
TL;DR: Improvements in understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections.
Journal ArticleDOI
Biofilms: Survival Mechanisms of Clinically Relevant Microorganisms
TL;DR: It is understood that biofilms are universal, occurring in aquatic and industrial water systems as well as a large number of environments and medical devices relevant for public health, and that treatments may be based on inhibition of genes involved in cell attachment and biofilm formation.
Journal ArticleDOI
Nosocomial Bloodstream Infections in US Hospitals: Analysis of 24,179 Cases from a Prospective Nationwide Surveillance Study
Hilmar Wisplinghoff,Tammy Bischoff,Sandra M. Tallent,Harald Seifert,Richard P. Wenzel,Michael B. Edmond +5 more
TL;DR: The proportion of nosocomial BSIs due to antibiotic-resistant organisms is increasing in US hospitals, and in neutropenic patients, infections with Candida species, enterococci, and viridans group streptococci were significantly more common.
Journal ArticleDOI
Acinetobacter baumannii: Emergence of a Successful Pathogen
TL;DR: This review details the significant advances that have been made in understanding of this remarkable organism over the last 10 years, including current taxonomy and species identification, issues with susceptibility testing, mechanisms of antibiotic resistance, global epidemiology, clinical impact of infection, host-pathogen interactions, and infection control and therapeutic considerations.
Journal ArticleDOI
An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii.
TL;DR: An overview of the current knowledge of the genus Acinetobacter is presented, with the emphasis on the clinically most important species, Acetobacter baumannii.