Acinetobacter baumannii: Human infections, factors contributing to pathogenesis and animal models
TLDR
This review summarizes the characteristics of A. baumannii that contribute to its pathogenesis, with a focus on motility, adherence, biofilm formation, and iron acquisition.Abstract:
Acinetobacter baumannii has emerged as a medically important pathogen because of the increasing number of infections produced by this organism over the preceding three decades and the global spread of strains with resistance to multiple antibiotic classes. In spite of its clinical relevance, until recently, there have been few studies addressing the factors that contribute to the pathogenesis of this organism. The availability of complete genome sequences, molecular tools for manipulating the bacterial genome, and animal models of infection have begun to facilitate the identification of factors that play a role in A. baumannii persistence and infection. This review summarizes the characteristics of A. baumannii that contribute to its pathogenesis, with a focus on motility, adherence, biofilm formation, and iron acquisition. In addition, the virulence factors that have been identified to date, which include the outer membrane protein OmpA, phospholipases, membrane polysaccharide components, penicillin-binding proteins, and outer membrane vesicles, are discussed. Animal models systems that have been developed during the last 15 years for the study of A. baumannii infection are overviewed, and the recent use of these models to identify factors involved in virulence and pathogenesis is highlighted.read more
Citations
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Acinetobacter baumannii: evolution of a global pathogen.
TL;DR: The recent expansion of A. baumannii sequenced genomes has permitted the development of large-array phylogenomic and phenotypic analyses, which can offer valuable insights into the evolution and adaptation of the human pathogen.
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Clinical and Pathophysiological Overview of Acinetobacter Infections: a Century of Challenges.
Darren Wong,Travis B. Nielsen,Robert A. Bonomo,Paul Pantapalangkoor,Brian Luna,Brad Spellberg,Brad Spellberg +6 more
TL;DR: Given its high rate of antibiotic resistance and abysmal outcomes (up to 70% mortality rate from infections caused by XDR strains in some case series), new preventative and therapeutic options for Acinetobacter spp.
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Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options.
Chang-Ro Lee,Jung Hun Lee,Moonhee Park,Kwang Seung Park,Il Kwon Bae,Young Bae Kim,Chang-Jun Cha,Byeong Chul Jeong,Sang Hee Lee +8 more
TL;DR: Current studies on the virulence factors that contribute to A. baumannii pathogenesis are summarized and Mechanisms of antibiotic resistance of this organism, including acquirement of β-lactamases, up-regulation of multidrug efflux pumps, modification of aminoglycosides, permeability defects, and alteration of target sites are discussed.
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The OmpA family of proteins: roles in bacterial pathogenesis and immunity.
Anthony W. Confer,Sahlu Ayalew +1 more
TL;DR: Among many of the pathogenic bacteria, OmpA proteins have important pathogenic roles including bacterial adhesion, invasion, or intracellular survival as well as evasion of host defenses or stimulators of pro-inflammatory cytokine production.
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Bacteriophage Therapy: Clinical Trials and Regulatory Hurdles.
TL;DR: This review discusses the multi-drug resistant Gram-negative pathogens of highest critical priority and summarizes the current state-of-the-art in phage therapy targeting these organisms.
References
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Journal ArticleDOI
Identification and structural determination of the capsular polysaccharides from two Acinetobacter baumannii clinical isolates, MG1 and SMAL.
Eleonora Fregolino,Valentina Gargiulo,Rosa Lanzetta,Michelangelo Parrilli,Otto Holst,Cristina De Castro +5 more
TL;DR: The structures of the capsular polysaccharides of the two clinical isolates Acinetobacter baumannii SMAL and MG1 were elucidated, proving that they were not the LPS O-antigens but CPSs.
Journal ArticleDOI
Screening for Acinetobacter baumannii Colonization by Use of Sponges
Yohei Doi,Ezenwa O. Onuoha,Jennifer M. Adams-Haduch,Diana L. Pakstis,Traci L. McGaha,Carly A. Werner,Bridget N. Parker,Maria M. Brooks,Kathleen A. Shutt,Anthony W. Pasculle,Carlene A. Muto,Lee H. Harrison +11 more
TL;DR: The novel screening method using sterile sponges was easy to perform and achieved excellent sensitivity for the detection of A. baumannii colonization.
Journal ArticleDOI
Yeast of the oral cavity is the reservoir of Heliobacter pylori
TL;DR: The intracellular occurrence of H. pylori in the oral yeast was assessed by targeting vacuolating cytotoxin A (vacA s1s2) and ureAB genes in the total DNAs of yeasts and showed the endosymbiotic relationship might explain the persistence of the bacterium in the Oral cavity.
Journal ArticleDOI
Efficacy of colistin-impregnated beads to prevent multidrug-resistant A. baumannii implant-associated osteomyelitis.
Daniel P. Crane,Kirill Gromov,Kirill Gromov,Dan Li,Kjeld Søballe,Christian Wahnes,Hubert Büchner,Matthew J. Hilton,Regis J. O'Keefe,Clinton K. Murray,Edward M. Schwarz +10 more
TL;DR: A mouse model with MDR strains isolated from wounded military personnel with A. baumannii OM results in blastic lesions that do not contain apparent biofilm, and develops a real‐time quantitative PCR (RTQ‐PCR) assay that could detect as few as 10 copies of parC in a sample.
Journal Article
Quorum sensing signal profile of Acinetobacter strains from nosocomial and environmental sources.
TL;DR: Quorum sensors in Acinetobacter are not homogenously distributed among species and one of them is present in most of the A. calcoaceticus-A.