Acinetobacter baumannii: Human infections, factors contributing to pathogenesis and animal models
TLDR
This review summarizes the characteristics of A. baumannii that contribute to its pathogenesis, with a focus on motility, adherence, biofilm formation, and iron acquisition.Abstract:
Acinetobacter baumannii has emerged as a medically important pathogen because of the increasing number of infections produced by this organism over the preceding three decades and the global spread of strains with resistance to multiple antibiotic classes. In spite of its clinical relevance, until recently, there have been few studies addressing the factors that contribute to the pathogenesis of this organism. The availability of complete genome sequences, molecular tools for manipulating the bacterial genome, and animal models of infection have begun to facilitate the identification of factors that play a role in A. baumannii persistence and infection. This review summarizes the characteristics of A. baumannii that contribute to its pathogenesis, with a focus on motility, adherence, biofilm formation, and iron acquisition. In addition, the virulence factors that have been identified to date, which include the outer membrane protein OmpA, phospholipases, membrane polysaccharide components, penicillin-binding proteins, and outer membrane vesicles, are discussed. Animal models systems that have been developed during the last 15 years for the study of A. baumannii infection are overviewed, and the recent use of these models to identify factors involved in virulence and pathogenesis is highlighted.read more
Citations
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Effect of calcium on the interaction of Acinetobacter baumannii with human respiratory epithelial cells
Yi Chen,Tingjun Shao,Sanhua Fang,Ping Pan,Jiahui Jiang,Tongtong Cheng,Haitong Wan,Daojun Yu,Daojun Yu +8 more
TL;DR: Effective control of calcium concentrations can provide new approaches for the prevention and treatment of multi-drug resistant Ab by regulating the expression of Ab-related genes.
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Deciphering the virulence factors, regulation, and immune response to Acinetobacter baumannii infection
TL;DR: A. baumannii is a gram-negative multidrug-resistant nosocomial pathogen and a major cause of hospital acquired infetions with a mortality rate up to 35% as discussed by the authors .
Dissertation
Effects of boesenbergia rotunda (L) mansf extract and cell wall inhibitor antibiotics against drug-resistant bacteria and the development of phenotypic assays to detect beta-lactamases
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A unique antigen against SARS-CoV-2, Acinetobacter baumannii, and Pseudomonas aeruginosa
Mohammad Rahbar,Shaden M.H. Mubarak,Anahita Hessami,Bahman Khalesi,Navid Pourzardosht,Saeed Khalili,Kobra Ahmadi Zanoos,Abolfazl Jahangiri +7 more
TL;DR: In this paper , an all-in-one antigen was designed based on an innovative, state-of-the-art strategy, which includes five antigenic peptides of spike protein, which are involved in SARS-CoV-2 pathogenicity.
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Unfolding of Acinetobacter baumannii MurA proceeds through a metastable intermediate: A combined spectroscopic and computational investigation.
TL;DR: This study systematically examined the urea-induced unfolding of Acinetobacter baumannii MurA (AbMurA) using various optical spectroscopic techniques and molecular dynamics simulations and observed a clear correlation between both in vitro and in silico studies.
References
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TL;DR: This review details the significant advances that have been made in understanding of this remarkable organism over the last 10 years, including current taxonomy and species identification, issues with susceptibility testing, mechanisms of antibiotic resistance, global epidemiology, clinical impact of infection, host-pathogen interactions, and infection control and therapeutic considerations.
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