Acinetobacter baumannii: Human infections, factors contributing to pathogenesis and animal models
TLDR
This review summarizes the characteristics of A. baumannii that contribute to its pathogenesis, with a focus on motility, adherence, biofilm formation, and iron acquisition.Abstract:
Acinetobacter baumannii has emerged as a medically important pathogen because of the increasing number of infections produced by this organism over the preceding three decades and the global spread of strains with resistance to multiple antibiotic classes. In spite of its clinical relevance, until recently, there have been few studies addressing the factors that contribute to the pathogenesis of this organism. The availability of complete genome sequences, molecular tools for manipulating the bacterial genome, and animal models of infection have begun to facilitate the identification of factors that play a role in A. baumannii persistence and infection. This review summarizes the characteristics of A. baumannii that contribute to its pathogenesis, with a focus on motility, adherence, biofilm formation, and iron acquisition. In addition, the virulence factors that have been identified to date, which include the outer membrane protein OmpA, phospholipases, membrane polysaccharide components, penicillin-binding proteins, and outer membrane vesicles, are discussed. Animal models systems that have been developed during the last 15 years for the study of A. baumannii infection are overviewed, and the recent use of these models to identify factors involved in virulence and pathogenesis is highlighted.read more
Citations
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Rapid detection of antibiotic resistance in Acinetobacter baumannii using quantitative real-time PCR
TL;DR: The use of real-time PCR to monitor bacterial growth in the presence of antibiotics is effective for rapidly identifying antibiotic resistance in A. baumannii.
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Lipopolysaccharide-Deficient Acinetobacter baumannii Due to Colistin Resistance Is Killed by Neutrophil-Produced Lysozyme
Go Kamoshida,Takuya Akaji,Norihiko Takemoto,Yusuke Suzuki,Yoshinori Sato,Daichi Kai,Taishi Hibino,Daiki Yamaguchi,Takane Kikuchi-Ueda,Satoshi Nishida,Yuka Unno,Shigeru Tansho-Nagakawa,Tsuneyuki Ubagai,Tohru Miyoshi-Akiyama,Masataka Oda,Yasuo Ono +15 more
TL;DR: Analysis of interactions between these strains and neutrophils revealed that neutrophil-secreted lysozyme was the antimicrobial factor during clearance of LPS-deficient A. baumannii strains, and may inform the development of targeted therapeutics aimed to treat multidrug-resistant infections in immunocompromised patients who are unable to mount an appropriate cell-mediated immune response.
Journal ArticleDOI
A catchment-scale assessment of the sanitary condition of treated wastewater and river water based on fecal indicators and carbapenem-resistant Acinetobacter spp
TL;DR: An extensive study of the sanitary conditions of river water and treated wastewater from seventeen WWTPs of various sizes along the Pilica River catchment in central Poland shows that this type of comprehensive analysis may enable assessment of the use of the entire catchment area, thus identifying the most serious threats to surface water quality and guiding the actions needed to improve the worst operatingWWTPs.
Journal ArticleDOI
Inactivation of Acinetobacter baumannii Biofilms on Polystyrene, Stainless Steel, and Urinary Catheters by Octenidine Dihydrochloride
Amoolya Narayanan,Meera Surendran Nair,Deepti Prasad Karumathil,Sangeetha Ananda Baskaran,Kumar Venkitanarayanan,Mary Anne Roshni Amalaradjou +5 more
TL;DR: The efficacy of octenidine dihydrochloride (OH) in inactivating A. baumannii biofilms is investigated, suggesting its potential use as a disinfectant or a catheter lock solution to control A.
Journal ArticleDOI
Modeling Acinetobacter baumannii wound infections: The critical role of iron.
Irma D. Fleming,Monika A. Krezalek,Natalia Belogortseva,Alexander Zaborin,Jennifer R. DeFazio,Laxmipradha Chandrasekar,Luis A. Actis,Olga Zaborina,John C. Alverdy +8 more
TL;DR: The ability of A. baumannii to cause infections in traumatized wound relies on its ability to scavenge iron and can be prevented by iron supplementation to the wound milieu.
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