Journal ArticleDOI
Activation of innate immune responses in a pathogen-mimicking manner by amphiphilic polyanhydride nanoparticle adjuvants.
Latrisha K. Petersen,Amanda E. Ramer-Tait,Scott Broderick,Chang-Sun Kong,Bret D. Ulery,Krishna Rajan,Michael J. Wannemuehler,Balaji Narasimhan +7 more
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TLDR
The approach outlined herein demonstrates the ability to rationally design pathogen-mimicking nanoparticle adjuvants for use in next-generation vaccines against emerging and re-emerging diseases.About:
This article is published in Biomaterials.The article was published on 2011-10-01. It has received 128 citations till now. The article focuses on the topics: Polyanhydrides.read more
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Synthetic Nanoparticles for Vaccines and Immunotherapy
TL;DR: A review of nanoparticle-based strategies to immune modulation in detail, and discuss the promise and outstanding challenges facing the field of immune engineering from a chemical biology/materials engineering perspective can be found in this article.
Journal ArticleDOI
Engineering synthetic vaccines using cues from natural immunity
TL;DR: A rapidly growing field of research is the design of vaccines based on synthetic materials to target organs, tissues, cells or intracellular compartments; to co-deliver immunomodulatory signals that control the quality of the immune response; or to act directly as immune regulators.
Journal ArticleDOI
Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype.
Stacey L. Demento,Weiguo Cui,Jason M. Criscione,Eric Stern,Jacob E. Tulipan,Susan M. Kaech,Tarek M. Fahmy +6 more
TL;DR: This study highlights the importance of sustained antigen release mediated by particulate platforms and its role in the long-term appearance of effector memory cellular response and compares the efficacy of Vesicular and solid biodegradable polymer platforms.
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Recent advances of self-assembling peptide-based hydrogels for biomedical applications
TL;DR: This review describes several methods commonly used for the fabrication of robust peptide-based hydrogels, including spontaneous hydrogelation, enzyme-controlled hydrogalation and cross-linking-enhanced hydrogELation, and introduces some representative studies on their applications in drug delivery and antitumor therapy, antimicrobial and wound healing materials, and 3D biop printing and tissue engineering.
Journal ArticleDOI
Multifunctional nanoparticles for targeted delivery of immune activating and cancer therapeutic agents.
TL;DR: Overall, this comprehensive review demonstrates that multifunctional NPs have distinctive properties that make them highly suitable for targeted therapeutic delivery in these areas.
References
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Book
Applied Multivariate Statistical Analysis
R. A. Johnson,Dean W. Wichern +1 more
TL;DR: In this article, the authors present an overview of the basic concepts of multivariate analysis, including matrix algebra and random vectors, as well as a strategy for analyzing multivariate models.
Journal ArticleDOI
Applied Multivariate Statistical Analysis.
TL;DR: In this article, the authors present an overview of the basic concepts of multivariate analysis, including matrix algebra and random vectors, as well as a strategy for analyzing multivariate models.
Journal ArticleDOI
Immunobiology of Dendritic Cells
Jacques Banchereau,Francine Brière,Christophe Caux,Jean Davoust,Serge Lebecque,Yong-Jun Liu,Bali Pulendran,Karolina Palucka +7 more
TL;DR: Dendritic cells are antigen-presenting cells with a unique ability to induce primary immune responses and may be important for the induction of immunological tolerance, as well as for the regulation of the type of T cell-mediated immune response.
Book
Immunobiology: The Immune System in Health and Disease
TL;DR: Introductory immunology textbook for medical students, advanced undergraduates, and graduate students.