Journal ArticleDOI
Acute kidney injury overview: From basic findings to new prevention and therapy strategies.
Sabrina R. Gonsalez,Aline Leal Cortes,Raquel Costa da Silva,Jennifer Lowe,Minolfa C. Prieto,Lucienne S. Lara +5 more
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TLDR
A recent review as mentioned in this paper discusses emerging strategies from basic science toward the anticipation of features, treatment of acute kidney injury (AKI), and new treatments using pharmacological and stem cell therapies.About:
This article is published in Pharmacology & Therapeutics.The article was published on 2019-04-06. It has received 89 citations till now. The article focuses on the topics: Renal replacement therapy & Acute kidney injury.read more
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Activation of TFEB-mediated autophagy by trehalose attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury.
Lingling Zhu,Yujia Yuan,Longhui Yuan,Lan Li,Fei Liu,Jingping Liu,Younan Chen,Yanrong Lu,Jingqiu Cheng +8 more
TL;DR: The data suggest that trehalose treatment preserves mitochondria function via activation of TFEB-mediated autophagy and attenuates cisplatin-induced kidney injury.
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Quercetin protects against cisplatin‐induced acute kidney injury by inhibiting Mincle/Syk/NF‐κB signaling maintained macrophage inflammation
TL;DR: A new mechanism of quercetin improving AKI‐induced kidney inflammation and injury is clarified, which provides a new drug option for the clinical treatment of AKI.
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Carbon monoxide: An emerging therapy for acute kidney injury.
TL;DR: This review will examine and make the case that CO be developed into a therapeutic agent against AKI, a common clinical problem that develops in patients receiving cisplatin therapies for a number of different solid organ malignancies.
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Ferroptosis and kidney diseases.
Shumei Tang,Xiangcheng Xiao +1 more
TL;DR: This review summarizes current research on ferroptosis, its underlying mechanisms and its role in the progression of different kidney diseases to provide more information regarding treatment and prevention of these destructive diseases.
References
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KDIGO clinical practice guidelines for acute kidney injury.
TL;DR: The guidelines focused on 4 key domains: (1) AKI definition, (2) prevention and treatment of AKI, (3) contrastinduced AKI (CI-AKI) and (4) dialysis interventions for the treatment ofAKI.
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Drug repositioning: identifying and developing new uses for existing drugs
Ted T. Ashburn,Karl B. Thor +1 more
TL;DR: Repositioning existing drugs for new indications could deliver the productivity increases that the industry needs while shifting the locus of production to biotechnology companies.
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Identification of Neutrophil Gelatinase-Associated Lipocalin as a Novel Early Urinary Biomarker for Ischemic Renal Injury
Jaya Mishra,Qing Ma,Anne E. Prada,Mark Mitsnefes,Kamyar Zahedi,Jun Yang,Jonathan Barasch,Prasad Devarajan +7 more
TL;DR: The results indicate that NGAL may represent an early, sensitive, noninvasive urinary biomarker for ischemic and nephrotoxic renal injury.
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Cellular pathophysiology of ischemic acute kidney injury
Joseph V. Bonventre,Li Yang +1 more
TL;DR: The major components of this dynamic process, which involves hemodynamic alterations, inflammation, and endothelial and epithelial cell injury, followed by repair that can be adaptive and restore epithelial integrity or maladaptive, leading to chronic kidney disease are reviewed.
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Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery.
Janina Ratajczak,Katarzyna Miekus,Magdalena Kucia,Jin Zhang,Ryan Reca,Petr Dvorak,Mariusz Z. Ratajczak +6 more
TL;DR: ES-MV isolated from murine ES cells in serum-free cultures significantly enhanced survival and improved expansion of murine HPC, and upregulated the expression of early pluripotent and early hematopoietic stem cells in these cells.