Adaptation of Lipid Profiling in Depression Disease and Treatment: A Critical Review
TLDR
Evidence that antidepressants seem to counteract the modification seen in lipids in MDD is given, giving some evidence that certain altered lipid profiles could be useful MDD biomarkers for future precision medicine.Abstract:
Major depressive disorder (MDD), also called depression, is a serious disease that impairs the quality of life of patients and has a high incidence, affecting approximately 3.8% of the world population. Its diagnosis is very subjective and is not supported by measurable biomarkers mainly due to the lack of biochemical markers. Recently, disturbance of lipid profiling has been recognized in MDD, in animal models of MDD or in depressed patients, which may contribute to unravel the etiology of the disease and find putative new biomarkers, for a diagnosis or for monitoring the disease and therapeutics outcomes. In this review, we provide an overview of current knowledge of lipidomics analysis, both in animal models of MDD (at the brain and plasma level) and in humans (in plasma and serum). Furthermore, studies of lipidomics analyses after antidepressant treatment in rodents (in brain, plasma, and serum), in primates (in the brain) and in humans (in plasma) were reviewed and give evidence that antidepressants seem to counteract the modification seen in lipids in MDD, giving some evidence that certain altered lipid profiles could be useful MDD biomarkers for future precision medicine.read more
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References
More filters
Journal ArticleDOI
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
TL;DR: Preliminary data from patients with inflammatory disorders, as well as medically healthy depressed patients, suggest that inhibiting proinflammatory cytokines or their signaling pathways may improve depressed mood and increase treatment response to conventional antidepressant medication.
Journal ArticleDOI
The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis
Karen Hughes,Mark A Bellis,Katherine A. Hardcastle,Dinesh Sethi,Alexander Butchart,Christopher Mikton,Lisa Jones,Michael P. Dunne +7 more
TL;DR: In this paper, a systematic review and meta-analysis was conducted to identify the harmful effects that adverse childhood experiences (ACEs; occurring during childhood or adolescence; eg, child maltreatment or exposure to domestic violence) have on health throughout life.
Journal ArticleDOI
A comprehensive classification system for lipids
Eoin Fahy,Shankar Subramaniam,H. Alex Brown,Christopher K. Glass,Alfred H. Merrill,Robert C. Murphy,Christian R. H. Raetz,David W. Russell,Yousuke Seyama,Walter A. Shaw,Takao Shimizu,Friedrich Spener,Gerrit van Meer,Michael S. VanNieuwenhze,Stephen H. White,Joseph L. Witztum,Edward A. Dennis +16 more
TL;DR: A comprehensive classification of lipids with a common platform that is compatible with informatics requirements has been developed to deal with the massive amounts of data that will be generated by the lipid community.
Journal ArticleDOI
Update of the LIPID MAPS comprehensive classification system for lipids
Eoin Fahy,Shankar Subramaniam,Robert C. Murphy,Masahiro Nishijima,Christian R. H. Raetz,Takao Shimizu,Friedrich Spener,Gerrit van Meer,Michael J.O. Wakelam,Edward A. Dennis +9 more
TL;DR: The International Lipid Classification and Nomenclature Committee under the sponsorship of the LIPID MAPS Consortium developed and established a "Comprehensive Classification System for Lipids" based on well defined chemical and biochemical principles and using an ontology that is extensible, flexible, and scalable as mentioned in this paper.
Journal ArticleDOI
Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression
TL;DR: The dopamine system is unique among the brain's modulatory systems in that it has discrete projections to specific brain regions involved in motor behaviour, cognition and emotion.