R
Rachel S. Kelly
Researcher at Brigham and Women's Hospital
Publications - 137
Citations - 3421
Rachel S. Kelly is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Medicine & Population. The author has an hindex of 26, co-authored 106 publications receiving 2466 citations. Previous affiliations of Rachel S. Kelly include Medical Research Council & Michigan State University.
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Journal ArticleDOI
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia
Sonja I. Berndt,Christine F. Skibola,Christine F. Skibola,Vijai Joseph,Nicola J. Camp,Alexandra Nieters,Zhaoming Wang,Wendy Cozen,Alain Monnereau,Sophia S. Wang,Rachel S. Kelly,Qing Lan,Lauren R. Teras,Nilanjan Chatterjee,Charles C. Chung,Meredith Yeager,Angela Brooks-Wilson,Angela Brooks-Wilson,Patricia Hartge,Mark P. Purdue,Brenda M. Birmann,Bruce K. Armstrong,Pierluigi Cocco,Yawei Zhang,Gianluca Severi,Anne Zeleniuch-Jacquotte,Charles E. Lawrence,Laurie Burdette,Jeffrey Yuenger,Amy Hutchinson,Kevin B. Jacobs,Timothy G. Call,Tait D. Shanafelt,Anne J. Novak,Neil E. Kay,Mark Liebow,Alice H. Wang,Karin E. Smedby,Hans-Olov Adami,Hans-Olov Adami,Mads Melbye,Bengt Glimelius,Bengt Glimelius,Ellen T. Chang,Ellen T. Chang,Martha Glenn,Karen Curtin,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Brandt Jones,W. Ryan Diver,Brian K. Link,George J. Weiner,Lucia Conde,Lucia Conde,Paige M. Bracci,Jacques Riby,Elizabeth A. Holly,Martyn T. Smith,Rebecca D. Jackson,Lesley F. Tinker,Yolanda Benavente,Nikolaus Becker,Paolo Boffetta,Paul Brennan,Lenka Foretova,Marc Maynadié,James McKay,Anthony Staines,Kari G. Rabe,Sara J. Achenbach,Celine M. Vachon,Lynn R. Goldin,Sara S. Strom,Mark C. Lanasa,Logan G. Spector,Jose F. Leis,Julie M. Cunningham,J. Brice Weinberg,Vicki A. Morrison,Neil E. Caporaso,Aaron D. Norman,Martha S. Linet,Anneclaire J. De Roos,Lindsay M. Morton,Richard K. Severson,Elio Riboli,Paolo Vineis,Rudolf Kaaks,Dimitrios Trichopoulos,Dimitrios Trichopoulos,Giovanna Masala,Elisabete Weiderpass,María Dolores Chirlaque,Roel Vermeulen,Ruth C. Travis,Graham G. Giles,Demetrius Albanes,Jarmo Virtamo,Stephanie J. Weinstein,Jacqueline Clavel,Tongzhang Zheng,Theodore R. Holford,Kenneth Offit,Andrew D. Zelenetz,Robert J. Klein,John J. Spinelli,Kimberly A. Bertrand,Francine Laden,Edward Giovannucci,Peter Kraft,Anne Kricker,Jenny Turner,Claire M. Vajdic,Maria Grazia Ennas,Giovanni Maria Ferri,Lucia Miligi,Liming Liang,Joshua N. Sampson,Simon Crouch,Ju-Hyun Park,Kari E. North,Angela Cox,John A. Snowden,Josh Wright,Angel Carracedo,Carlos López-Otín,Sílvia Beà,Itziar Salaverria,David Martín-García,Elias Campo,Joseph F. Fraumeni,Silvia de Sanjosé,Henrik Hjalgrim,James R. Cerhan,Stephen J. Chanock,Nathaniel Rothman,Susan L. Slager +137 more
TL;DR: The largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls, identified ten independent associated SNPs in nine new loci and found evidence for two additional promising loci below genome-wide significance.
Journal ArticleDOI
Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types
Joshua N. Sampson,William Wheeler,Meredith Yeager,Orestis A. Panagiotou,Zhaoming Wang,Sonja I. Berndt,Qing Lan,Christian C. Abnet,Laufey T. Amundadottir,Jonine D. Figueroa,Maria Teresa Landi,Lisa Mirabello,Sharon A. Savage,Philip R. Taylor,Immaculata De Vivo,Katherine A. McGlynn,Mark P. Purdue,Preetha Rajaraman,Hans-Olov Adami,Anders Ahlbom,Demetrius Albanes,Maria Fernanda Amary,Maria Fernanda Amary,She-Juan An,Ulrika Andersson,Gerald L. Andriole,Irene L. Andrulis,Emanuele Angelucci,Stephen M. Ansell,Cecilia Arici,Bruce K. Armstrong,Alan A. Arslan,Melissa A. Austin,Dalsu Baris,Donald A. Barkauskas,Bryan A. Bassig,Bryan A. Bassig,Nikolaus Becker,Yolanda Benavente,Simone Benhamou,Simone Benhamou,Christine D. Berg,David Van Den Berg,David Van Den Berg,Leslie Bernstein,Leslie Bernstein,Kimberly A. Bertrand,Brenda M. Birmann,Amanda Black,Heiner Boeing,Paolo Boffetta,Marie-Christine Boutron-Ruault,Paige M. Bracci,Louise A. Brinton,Angela Brooks-Wilson,Angela Brooks-Wilson,H. Bas Bueno-de-Mesquita,Laurie Burdett,Julie E. Buring,Julie E. Buring,Mary Ann Butler,Qiuyin Cai,Geraldine Cancel-Tassin,Federico Canzian,Alfredo Carrato,Tania Carreón,Tania Carreón,Angela Carta,John K.C. Chan,Ellen T. Chang,Ellen T. Chang,Gee-Chen Chang,I. Shou Chang,Jiang Chang,Jenny Chang-Claude,Chien-Jen Chen,Chih Yi Chen,Chu Chen,Chung Hsing Chen,Constance Chen,Hongyan Chen,Kexin Chen,Kuan-Yu Chen,Kun-Chieh Chen,Ying Chen,Ying Hsiang Chen,Yi Song Chen,Yuh Min Chen,Li Hsin Chien,Maria Dolores Chirlaque,Jin Eun Choi,Yi Young Choi,Wong-Ho Chow,Charles C. Chung,Jacqueline Clavel,Françoise Clavel-Chapelon,Françoise Clavel-Chapelon,Pierluigi Cocco,Joanne S. Colt,Eva Comperat,Lucia Conde,Joseph M. Connors,Joseph M. Connors,David V. Conti,David V. Conti,Victoria K. Cortessis,Michelle Cotterchio,Wendy Cozen,Simon Crouch,Marta Crous-Bou,Olivier Cussenot,Faith G. Davis,Ti Ding,W. Ryan Diver,M. Dorronsoro,Laure Dossus,Eric J. Duell,M. G. Ennas,Ralph L. Erickson,Maria Feychting,Adrienne M. Flanagan,Adrienne M. Flanagan,Lenka Foretova,Joseph F. Fraumeni,Neal D. Freedman,Laura E. Beane Freeman,Charles S. Fuchs,Charles S. Fuchs,Manuela Gago-Dominguez,Steven Gallinger,Yu-Tang Gao,Susan M. Gapstur,Montserrat Garcia-Closas,Reina García-Closas,Randy D. Gascoyne,Julie M. Gastier-Foster,Julie M. Gastier-Foster,Mia M. Gaudet,J. Michael Gaziano,J. Michael Gaziano,Carol Giffen,Graham G. Giles,Graham G. Giles,Edward Giovannucci,Bengt Glimelius,Bengt Glimelius,Michael Goggins,Nalan Gokgoz,Alisa M. Goldstein,Richard Gorlick,Myron D. Gross,Robert L. Grubb,Jian Gu,Peng Guan,Marc J. Gunter,Huan Guo,Thomas M. Habermann,Christopher A. Haiman,Dina Halai,Dina Halai,Göran Hallmans,Manal M. Hassan,Claudia Maria Hattinger,Qincheng He,Xingzhou He,Kathy J. Helzlsouer,Brian E. Henderson,Roger Henriksson,Henrik Hjalgrim,Henrik Hjalgrim,Judith Hoffman-Bolton,Chancellor Hohensee,Theodore R. Holford,Elizabeth A. Holly,Yun-Chul Hong,Robert N. Hoover,Pamela L. Horn-Ross,G. M. Monawar Hosain,H. Dean Hosgood,Chin-Fu Hsiao,Chin-Fu Hsiao,Nan Hu,Wei Hu,Zhibin Hu,Ming Shyan Huang,José María Huerta,Jen Yu Hung,Amy Hutchinson,Peter D. Inskip,Rebecca D. Jackson,Eric J. Jacobs,Mazda Jenab,Hyo Sung Jeon,Bu Tian Ji,Guangfu Jin,Li Jin,Christoffer Johansen,Alison Johnson,Yoo Jin Jung,Rudolf Kaaks,Aruna Kamineni,Eleanor Kane,Chang Hyun Kang,Margaret R. Karagas,Rachel S. Kelly,Rachel S. Kelly,Kay-Tee Khaw,Christopher Kim,Hee Nam Kim,Hee Nam Kim,Jin Hee Kim,Jun Suk Kim,Yeul Hong Kim,Young Tae Kim,Young-Chul Kim,Cari M. Kitahara,Alison P. Klein,Robert J. Klein,Manolis Kogevinas,Takashi Kohno,Laurence N. Kolonel,Charles Kooperberg,Anne Kricker,Vittorio Krogh,Hideo Kunitoh,Robert C. Kurtz,Sun-Seog Kweon,Andrea La Croix,Charles E. Lawrence,Fernando Lecanda,Victor Ho-Fun Lee,Donghui Li,Haixin Li,Jihua Li,Yao Jen Li,Yuqing Li,Linda M. Liao,Mark Liebow,Tracy Lightfoot,Wei-Yen Lim,Chien Chung Lin,Dongxin Lin,Sara Lindström,Martha S. Linet,Brian K. Link,Chenwei Liu,Jianjun Liu,Li Liu,Börje Ljungberg,Josep Lloreta,Simonetta Di Lollo,Daru Lu,E. Lund,Núria Malats,Satu Männistö,Loic Le Marchand,Neyssa Marina,Giovanna Masala,Giuseppe Mastrangelo,Keitaro Matsuo,Marc Maynadie,James McKay,Roberta McKean-Cowdin,Mads Melbye,Mads Melbye,Beatrice Melin,Dominique S. Michaud,Dominique S. Michaud,Tetsuya Mitsudomi,Alain Monnereau,Rebecca Montalvan,Lee E. Moore,Lotte Maxild Mortensen,Alexandra Nieters,Kari E. North,Anne J. Novak,Ann L. Oberg,Kenneth Offit,In-Jae Oh,Sara H. Olson,Domenico Palli,William Pao,In Kyu Park,Jae Yong Park,Kyong Hwa Park,Ana Patiño-García,Sofia Pavanello,Petra H.M. Peeters,Petra H.M. Peeters,Reury Perng Perng,Ulrike Peters,Gloria M. Petersen,Piero Picci,Malcolm C. Pike,Stefano Porru,Jennifer Prescott,Ludmila Prokunina-Olsson,Biyun Qian,Biyun Qian,You-Lin Qiao,Marco Rais,Elio Riboli,Jacques Riby,Harvey A. Risch,Cosmeri Rizzato,Rebecca Rodabough,Eve Roman,Morgan Rouprêt,Avima M. Ruder,Silvia de Sanjosé,Silvia de Sanjosé,Ghislaine Scelo,Alan R. Schned,Fredrick R. Schumacher,Kendra Schwartz,Molly Schwenn,Katia Scotlandi,Adeline Seow,Consol Serra,Massimo Serra,Howard D. Sesso,Howard D. Sesso,Veronica Wendy Setiawan,Gianluca Severi,Gianluca Severi,Richard K. Severson,Tait D. Shanafelt,Hongbing Shen,Wei Shen,Min-Ho Shin,Kouya Shiraishi,Kouya Shiraishi,Xiao-Ou Shu,Afshan Siddiq,Luis Sierrasesúmaga,Alan D. L. Sihoe,Christine F. Skibola,Alex Smith,Martyn T. Smith,Melissa C. Southey,John J. Spinelli,Anthony Staines,Meir J. Stampfer,Marianna C. Stern,Marianna C. Stern,Victoria L. Stevens,Rachael S. Stolzenberg-Solomon,Jian Su,Wu Chou Su,Malin Sund,Jae Sook Sung,Sook Whan Sung,Wen Tan,Wei Tang,Adonina Tardón,Adonina Tardón,David Thomas,Carrie A. Thompson,Lesley F. Tinker,Roberto Tirabosco,Anne Tjønneland,Ruth C. Travis,Dimitrios Trichopoulos,Fang Yu Tsai,Ying-Huang Tsai,Margaret A. Tucker,Jenny Turner,Claire M. Vajdic,Roel Vermeulen,Danylo J. Villano,Paolo Vineis,Jarmo Virtamo,Kala Visvanathan,Jean Wactawski-Wende,Chaoyu Wang,Chih-Liang Wang,Jiucun Wang,Junwen Wang,Fusheng Wei,Elisabete Weiderpass,George J. Weiner,Stephanie J. Weinstein,Nicolas Wentzensen,Emily White,Thomas E. Witzig,Brian M. Wolpin,Maria Pik Wong,Chen Wu,Guoping Wu,Junjie Wu,Tangchun Wu,Tangchun Wu,Wei Wu,Xifeng Wu,Yi-Long Wu,Jay S. Wunder,Yong-Bing Xiang,Jun Xu,Ping Xu,Pan-Chyr Yang,Tsung-Ying Yang,Yuanqing Ye,Zhihua Yin,Jun Yokota,Ho Il Yoon,Chong-Jen Yu,Herbert Yu,Kai Yu,Jian-Min Yuan,Andrew D. Zelenetz,Anne Zeleniuch-Jacquotte,X. Zhang,Yawei Zhang,Xueying Zhao,Zhenhong Zhao,Hong Zheng,Tongzhang Zheng,Wei Zheng,Baosen Zhou,Meng Zhu,M Zucca,M Zucca,Simina M. Boca,James R. Cerhan,Giovanni Maria Ferri,Patricia Hartge,Chao Agnes Hsiung,Chao Agnes Hsiung,Corrado Magnani,Corrado Magnani,Corrado Magnani,Lucia Miligi,Lindsay M. Morton,Lindsay M. Morton,Lindsay M. Morton,Karin E. Smedby,Lauren R. Teras,Joseph Vijai,Sophia S. Wang,Paul Brennan,Neil E. Caporaso,David J. Hunter,David J. Hunter,Peter Kraft,Nathaniel Rothman,Debra T. Silverman,Susan L. Slager,Stephen J. Chanock,Nilanjan Chatterjee +448 more
TL;DR: Correlation analysis indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the Genetic etiology for the same disease can vary by population and environmental exposures.
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma
James R. Cerhan,Sonja I. Berndt,Joseph Vijai,Hervé Ghesquières,James D. McKay,Sophia S. Wang,Zhaoming Wang,Meredith Yeager,Lucia Conde,Paul I.W. de Bakker,Alexandra Nieters,David G. Cox,Laurie Burdett,Alain Monnereau,Christopher R. Flowers,Anneclaire J. De Roos,Anneclaire J. De Roos,Angela Brooks-Wilson,Angela Brooks-Wilson,Qing Lan,Gianluca Severi,Gianluca Severi,Mads Melbye,Mads Melbye,Jian Gu,Rebecca D. Jackson,Eleanor Kane,Lauren R. Teras,Mark P. Purdue,Claire M. Vajdic,John J. Spinelli,Graham G. Giles,Graham G. Giles,Demetrius Albanes,Rachel S. Kelly,Rachel S. Kelly,Mariagrazia Zucca,Kimberly A. Bertrand,Anne Zeleniuch-Jacquotte,Charles Lawrence,Amy K. Hutchinson,Degui Zhi,Thomas M. Habermann,Brian K. Link,Anne J. Novak,Ahmet Dogan,Yan W. Asmann,Mark Liebow,Carrie A. Thompson,Stephen M. Ansell,Thomas E. Witzig,George J. Weiner,Amelie S. Veron,Diana Zelenika,Hervé Tilly,Corinne Haioun,Thierry Jo Molina,Henrik Hjalgrim,Bengt Glimelius,Bengt Glimelius,Hans-Olov Adami,Hans-Olov Adami,Paige M. Bracci,Jacques Riby,Martyn T. Smith,Elizabeth A. Holly,Wendy Cozen,Patricia Hartge,Lindsay M. Morton,Richard K. Severson,Lesley F. Tinker,Kari E. North,Nikolaus Becker,Yolanda Benavente,Paolo Boffetta,Paul Brennan,Lenka Foretova,Marc Maynadie,Anthony Staines,Tracy Lightfoot,Simon Crouch,Alex Smith,Eve Roman,W. Ryan Diver,Kenneth Offit,Andrew D. Zelenetz,Robert J. Klein,Danylo J. Villano,Tongzhang Zheng,Yawei Zhang,Theodore R. Holford,Anne Kricker,Jenny Turner,Melissa C. Southey,Jacqueline Clavel,Jarmo Virtamo,Stephanie J. Weinstein,Elio Riboli,Paolo Vineis,Rudolph Kaaks,Dimitrios Trichopoulos,Dimitrios Trichopoulos,Roel Vermeulen,Heiner Boeing,Anne Tjønneland,Emanuele Angelucci,Simonetta Di Lollo,Marco Rais,Brenda M. Birmann,Francine Laden,Edward Giovannucci,Peter Kraft,Jinyan Huang,Baoshan Ma,Baoshan Ma,Yuanqing Ye,Brian C.-H. Chiu,Joshua N. Sampson,Liming Liang,Ju-Hyun Park,Charles C. Chung,Dennis D. Weisenburger,Nilanjan Chatterjee,Joseph F. Fraumeni,Susan L. Slager,Xifeng Wu,Silvia de Sanjosé,Karin E. Smedby,Gilles Salles,Gilles Salles,Christine F. Skibola,Nathaniel Rothman,Stephen J. Chanock +132 more
TL;DR: This paper conducted a meta-analysis of three new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls.
Journal ArticleDOI
Life-course socioeconomic status and DNA methylation of genes regulating inflammation
Silvia Stringhini,Silvia Polidoro,Carlotta Sacerdote,Rachel S. Kelly,Rachel S. Kelly,Karin van Veldhoven,Claudia Agnoli,Sara Grioni,Rosario Tumino,Maria Concetta Giurdanella,Salvatore Panico,Amalia Mattiello,Domenico Palli,Giovanna Masala,Valentina Gallo,Valentina Gallo,Raphaële Castagné,Fred Paccaud,Gianluca Campanella,Marc Chadeau-Hyam,Paolo Vineis +20 more
TL;DR: The hypothesis that the social environment leaves an epigenetic signature in cells may link SES to chronic disease risk is supported, and DNA methylation of genes involved in inflammation is found to be less methylated in individuals with low vs high SES.
Journal ArticleDOI
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.
James R. Cerhan,Sonja I. Berndt,Joseph Vijai,Hervé Ghesquières,James D. McKay,Sophia S. Wang,Zhaoming Wang,Meredith Yeager,Lucia Conde,Paul I.W. de Bakker,Alexandra Nieters,David G. Cox,Laurie Burdett,Alain Monnereau,Christopher R. Flowers,Anneclaire J. De Roos,Anneclaire J. De Roos,Angela Brooks-Wilson,Angela Brooks-Wilson,Qing Lan,Gianluca Severi,Gianluca Severi,Mads Melbye,Mads Melbye,Jian Gu,Rebecca D. Jackson,Eleanor Kane,Lauren R. Teras,Mark P. Purdue,Claire M. Vajdic,John J. Spinelli,Graham G. Giles,Graham G. Giles,Demetrius Albanes,Rachel S. Kelly,Rachel S. Kelly,Mariagrazia Zucca,Kimberly A. Bertrand,Anne Zeleniuch-Jacquotte,Charles Lawrence,Amy K. Hutchinson,Degui Zhi,Thomas M. Habermann,Brian K. Link,Anne J. Novak,Ahmet Dogan,Yan W. Asmann,Mark Liebow,Carrie A. Thompson,Stephen M. Ansell,Thomas E. Witzig,George J. Weiner,Amelie S. Veron,Diana Zelenika,Hervé Tilly,Corinne Haioun,Thierry Jo Molina,Henrik Hjalgrim,Bengt Glimelius,Bengt Glimelius,Hans-Olov Adami,Hans-Olov Adami,Paige M. Bracci,Jacques Riby,Martyn T. Smith,Elizabeth A. Holly,Wendy Cozen,Patricia Hartge,Lindsay M. Morton,Richard K. Severson,Lesley F. Tinker,Kari E. North,Nikolaus Becker,Yolanda Benavente,Paolo Boffetta,Paul Brennan,Lenka Foretova,Marc Maynadie,Anthony Staines,Tracy Lightfoot,Simon Crouch,Alex Smith,Eve Roman,W. Ryan Diver,Kenneth Offit,Andrew D. Zelenetz,Robert J. Klein,Danylo J. Villano,Tongzhang Zheng,Yawei Zhang,Theodore R. Holford,Anne Kricker,Jenny Turner,Melissa C. Southey,Jacqueline Clavel,Jarmo Virtamo,Stephanie J. Weinstein,Elio Riboli,Paolo Vineis,Rudolph Kaaks,Dimitrios Trichopoulos,Dimitrios Trichopoulos,Roel Vermeulen,Heiner Boeing,Anne Tjønneland,Emanuele Angelucci,Simonetta Di Lollo,Marco Rais,Brenda M. Birmann,Francine Laden,Edward Giovannucci,Peter Kraft,Jinyan Huang,Baoshan Ma,Baoshan Ma,Yuanqing Ye,Brian C.-H. Chiu,Joshua N. Sampson,Liming Liang,Ju-Hyun Park,Charles C. Chung,Dennis D. Weisenburger,Nilanjan Chatterjee,Joseph F. Fraumeni,Susan L. Slager,Xifeng Wu,Silvia de Sanjosé,Karin E. Smedby,Gilles Salles,Gilles Salles,Christine F. Skibola,Nathaniel Rothman,Stephen J. Chanock +132 more
TL;DR: Data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.