Journal ArticleDOI
Additive anticonvulsant effects of creatine supplementation and physical exercise against pentylenetetrazol-induced seizures
Leonardo Magno Rambo,Leandro Rodrigo Ribeiro,Mauro Schneider Oliveira,Mauro Schneider Oliveira,Ana Flávia Furian,Ana Flávia Furian,Frederico Diniz Lima,Mauren Assis Souza,Luiz Fernando Almeida Silva,Leandro Thies Retamoso,Cristiane Lenz Dalla Corte,Gustavo Orione Puntel,Daiana Silva Ávila,Félix Alexandre Antunes Soares,Michele Rechia Fighera,Carlos Fernando Mello,Luiz Fernando Freire Royes +16 more
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TLDR
It is found that 6 weeks of physical training or creatine supplementation decreased the duration of PTZ-induced seizures in adult male Wistar rats, and evidence is provided that combination between creatine supplementation and physical exercise may be a useful strategy in the treatment of convulsive disorders.About:
This article is published in Neurochemistry International.The article was published on 2009-10-01. It has received 58 citations till now. The article focuses on the topics: Creatine & Pentylenetetrazol.read more
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Journal ArticleDOI
Creatine as an antioxidant
Piero Sestili,Chiara Martinelli,Evelin Colombo,Elena Barbieri,Lucia Potenza,Stefano Sartini,Carmela Fimognari +6 more
TL;DR: A wide number of research articles indicate that Cr is capable of exerting multiple, non-energy related, effects on diverse and relevant cellular targets, and the antioxidant activity of Cr emerges as an additional mechanism which is likely to play a supportive role in the Cr-cytoprotection paradigm.
Journal ArticleDOI
Creatine biosynthesis and transport in health and disease.
Marie Joncquel-Chevalier Curt,Pia-Manuela Voicu,Monique Fontaine,Anne-Frédérique Dessein,Nicole Porchet,Karine Mention-Mulliez,Dries Dobbelaere,Gustavo Soto-Ares,David Cheillan,Joseph Vamecq,Joseph Vamecq +10 more
TL;DR: This review encompasses all aspects of creatine by providing an illustrated metabolic account for brain and body creatine in health and disease, an algorithm to diagnose metabolic and gene bases of primary and secondary creatine deficiencies, and a metabolic exploration by (1)H-MRS assessment of cerebral creatine levels and response to therapeutic measures.
Journal ArticleDOI
On the Run for Hippocampal Plasticity.
TL;DR: A comprehensive understanding of the body-brain axis is needed to elucidate how exercise improves hippocampal plasticity and cognition.
Journal ArticleDOI
Swimming training induces liver mitochondrial adaptations to oxidative stress in rats submitted to repeated exhaustive swimming bouts.
Frederico Diniz Lima,Daniel Neis Stamm,Iuri Domingues Della-Pace,Fernando Dobrachinski,Nelson Rodrigues de Carvalho,Luiz Fernando Freire Royes,Félix Alexandre Antunes Soares,João Rocha,Javier González-Gallego,Guilherme Bresciani +9 more
TL;DR: Swimming training induced positive adaptations in liver mitochondria of rats and protected against exhaustive swimming ROS production herein characterized by decreased oxidative stress markers, higher antioxidant defenses, and increases in methyl-tetrazolium reduction and membrane potential.
Journal ArticleDOI
Experimental and clinical findings from physical exercise as complementary therapy for epilepsy.
TL;DR: Considering that exercise can exert beneficial actions such as reduction of seizure susceptibility, reduction of anxiety and depression, and consequently, improvement of quality of life of individuals with epilepsy, exercise can be a potential candidate as non-pharmacological treatment of epilepsy.
References
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
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The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
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Catalase in vitro
TL;DR: In this article, the catalytic activity of catalase has been investigated using ultraviolet (UV) spectrophotometry and Titrimetric methods, which is suitable for comparative studies for large series of measurements.
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Determination of carbonyl content in oxidatively modified proteins.
Rodney L. Levine,Donita Garland,Cynthia N. Oliver,Adolfo Amici,Isabel Climent,Anke-G. Lenz,Bong-Whan Ahn,Shmuel Shaltiel,Earl R. Stadtman +8 more
TL;DR: This chapter discusses methods to determine carbonyl content in oxidatively modified proteins and quantitated protein-bound pyruvoyl groups through formation of a Schiff base with p-aminobenzoic acid followed by reduction with cyanoborohydride.
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Epilepsy : a comprehensive textbook
TL;DR: The neurobiology of epilepsy: neuronal excitability experimental modes of epilepsy and the autonomic nervous system comorbidity neuroendocrinology and the delivery of health care and socioeconomic issues.