Book ChapterDOI
Adverse Effects of Bisphenol A on Male Reproductive Function
Faustin Pascal Tsagué Manfo,R. Jubendradass,Edouard Akono Nantia,Paul F. Moundipa,Premendu P. Mathur,Premendu P. Mathur +5 more
Reads0
Chats0
TLDR
The overall BPA effects on male reproduction appear to be more harmful if exposure occurs in utero, and the regulation of BPA and BPA-related products should be reinforced, particularly where exposure during the fetal period can occur.Abstract:
BPA is a ubiquitous environmental contaminant, resulting mainly from manufacturing,use or disposal of plastics of which it is a component, and the degradation of industrial plastic-related wastes. Growing evidence from research on laboratory animals, wildlife, and humans supports the view that BPA produces an endocrine disrupting effect and adversely affects male reproductive function. To better understand the adverse effects caused by exposure to BPA, we performed an up-to-date literature review on the topic, with particular emphasis on in utero exposure, and associated effects on spermatogenesis, steroidogenesis, and accessory organs.BPA studies on experimental animals show that effects are generally more detrimental during in utero exposure, a critical developmental stage for the embryo. BPA has been found to produce several defects in the embryo, such as feminization of male fetuses, atrophy of the testes and epididymides, increased prostate size, shortening of AGD, disruption of BTB, and alteration of adult sperm parameters (e.g.,sperm count, motility, and density). BPA also affects embryo thyroid development.During the postnatal and pubertal periods and adulthood, BPA affects the hypothalamic-pituitary-testicular axis by modulating hormone (e.g., LH and FSH,androgen and estrogen) synthesis, expression and function of respective receptors(ER, AR). These effects alter sperm parameters. BPA also induces oxidative stress in the testis and epididymis, by inhibiting antioxidant enzymes and stimulating lipid peroxidation. This suggests that employing antioxidants may be a promising strategy to relieve BPA-induced disturbances.Epidemiological studies have also provided data indicating that BPA alters male reproductive function in humans. These investigations revealed that men occupationally exposed to BPA had high blood/urinary BPA levels, and abnormal semen parameters. BPA-exposed men also showed reduced libido and erectile ejaculatory difficulties; moreover, the overall BPA effects on male reproduction appear to be more harmful if exposure occurs in utero. The regulation of BPA and BPA-related products should be reinforced, particularly where exposure during the fetal period can occur. The current TDI for BPA is proposed as 25 and 50 1-1g/kg bwt/day (European Food Safety Authority and Health Canada, respectively). Based on the evidence available, we believe that a TDI value of 5 1-1g/kg bwt/day is more appropriate (the endpoint is modulation of rat testicular function). Certain BPA derivatives are being considered as alternatives to BPA. However, certain of these related products display adverse effects that are similar to those of BPA. These effects should be carefully considered before using them as final alternatives to BPA in plastic production.read more
Citations
More filters
Journal ArticleDOI
Adsorptive removal of bisphenol A (BPA) from aqueous solution: A review.
TL;DR: An overview of the recent research studies dealing with the BPA removal from water by adsorption method is presented and it is evident from the literature reviewed that modified adsorbents and composite materials have shown promising results for BPA Removal from water.
Journal ArticleDOI
Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease.
Ilaria Cimmino,Francesca Fiory,Giuseppe Perruolo,Claudia Miele,Francesco Beguinot,Pietro Formisano,Francesco Oriente +6 more
TL;DR: This review aims to provide an extensive and comprehensive analysis of the most recent evidence about the potential mechanisms by which BPA affects human health.
Journal ArticleDOI
A review on sources and health impacts of bisphenol A
TL;DR: In-depth studies are needed to understand the fate of these compounds particularly in the developing nations and the associated adverse health impacts of BPA due to prolonged exposure.
Journal ArticleDOI
High-energy diets: a threat for male fertility?
TL;DR: An up‐to‐date overview of the effects of HED on testicular metabolism, sperm parameters and the subsequent consequences for male fertility is presented.
Journal ArticleDOI
Oxidative Stress and BPA Toxicity: An Antioxidant Approach for Male and Female Reproductive Dysfunction.
TL;DR: Five classes of antioxidants—vitamins and co-factors, natural products (herbals and phytochemicals), melatonin, selenium, and methyl donors (used alone or in combination)—that have been found useful to counteract BPA toxicity in male and female reproductive functions are focused on.
References
More filters
Journal ArticleDOI
Male reproductive health and environmental xenoestrogens
Jorma Toppari,John Chr. Larsen,Peter Christiansen,Aleksander Giwercman,Philippe Grandjean,Louis J. Guillette,Bernard Jégou,Tina Kold Jensen,Pierre Jouannet,Niels Keiding,Henrik Leffers,John A. McLachlan,Otto A. Meyer,Jørn Müller,E. Rajpert-De Meyts,Thomas H. Scheike,Richard M. Sharpe,John P. Sumpter,Niels E. Skakkebæk +18 more
TL;DR: The growing number of reports demonstrating that common environmental contaminants and natural factors possess estrogenic activity presents the working hypothesis that the adverse trends in male reproductive health may be, at least in part, associated with exposure to estrogenic or other hormonally active environmental chemicals during fetal and childhood development.
Journal ArticleDOI
Bisphenol-A and the Great Divide: A Review of Controversies in the Field of Endocrine Disruption
TL;DR: This review has covered the above-mentioned controversies plus six additional issues that have divided scientists in the field of BPA research, namely: mechanisms of bisphenol-A action; levels of human exposure; 3) routes of human Exposure; 4) pharmacokinetic models of Bpa metabolism; 5) effects of B PA on exposed animals; and 6) links between BPA and cancer.
Journal ArticleDOI
Estrogenicity of resin-based composites and sealants used in dentistry.
Nicolás Olea,Rosa Pulgar,Pilar Perez,Fátima Olea-Serrano,Ana Rivas,Arantzazu Novillo-Fertrell,V. Pedraza,Ana M. Soto,Carlos Sonnenschein +8 more
TL;DR: The use of bis-GMA-based resins in dentistry, and particularly the use of sealants in children, appears to contribute to human exposure to xenoestrogens.
Journal ArticleDOI
Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population.
Antonia M. Calafat,Zsuzsanna Kuklenyik,John A. Reidy,Samuel P. Caudill,John Ekong,Larry L. Needham +5 more
TL;DR: This study provides the first reference range of human internal dose levels of BPA and NP in a demographically diverse human population and further research is needed to determine the best urinary biomarker(s) to assess exposure to NP.
Journal ArticleDOI
Large Effects from Small Exposures. III. Endocrine Mechanisms Mediating Effects of Bisphenol A at Levels of Human Exposure
TL;DR: Concern with human exposure to BPA derives from identification of molecular mechanisms mediating effects in human and animal tissues at very low doses, in vivo effects in experimental animals caused by low doses within the range of human exposure, and widespread human Exposure to levels of BPA that cause adverse effects in animals.