Alternative cleavage and polyadenylation: the long and short of it
Bin Tian,James L. Manley +1 more
TLDR
Current understanding of APA is reviewed, showing that alternative cleavage and polyadenylation is an important layer of gene regulation impacting mRNA metabolism.About:
This article is published in Trends in Biochemical Sciences.The article was published on 2013-06-01 and is currently open access. It has received 285 citations till now. The article focuses on the topics: Cleavage and polyadenylation specificity factor & Cleavage factor.read more
Citations
More filters
Journal ArticleDOI
Alternative polyadenylation of mRNA precursors.
Bin Tian,James L. Manley +1 more
TL;DR: The roles of APA in diverse cellular processes, including mRNA metabolism, protein diversification and protein localization, and more generally in gene regulation are discussed, and the molecular mechanisms underlying APA are discussed.
Journal ArticleDOI
Linking Long Noncoding RNA Localization and Function.
TL;DR: Investigating the mechanisms that determine the subcellular fate of lncRNAs has the potential to provide new insights into their biogenesis and specialized functions.
MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: In this article, a review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.
Journal ArticleDOI
RNA-Seq methods for transcriptome analysis
TL;DR: Current RNA‐Seq methods for general analysis of gene expression and several specific applications are reviewed, including isoform and gene fusion detection, digital gene expression profiling, targeted sequencing and single‐cell analysis.
Journal ArticleDOI
Regulation by 3'-Untranslated Regions.
TL;DR: 3'-UTRs seem to be major players in gene regulation that enable local functions, compartmentalization, and cooperativity, which makes them important tools for the regulation of phenotypic diversity of higher organisms.
References
More filters
Journal ArticleDOI
MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: The current understanding of miRNA target recognition in animals is outlined and the widespread impact of miRNAs on both the expression and evolution of protein-coding genes is discussed.
Journal ArticleDOI
A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
TL;DR: It is proposed that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.
Journal ArticleDOI
Alternative Isoform Regulation in Human Tissue Transcriptomes
Eric T. Wang,Rickard Sandberg,Rickard Sandberg,Shujun Luo,Irina Khrebtukova,Lu Zhang,Christine Mayr,Stephen F. Kingsmore,Gary P. Schroth,Christopher B. Burge +9 more
TL;DR: An in-depth analysis of 15 diverse human tissue and cell line transcriptomes on the basis of deep sequencing of complementary DNA fragments yielding a digital inventory of gene and mRNA isoform expression suggested common involvement of specific factors in tissue-level regulation of both splicing and polyadenylation.
Journal ArticleDOI
Molecular Mechanisms of Long Noncoding RNAs
Kevin C. Wang,Howard Y. Chang +1 more
TL;DR: These archetypes of lncRNA function may be a useful framework to consider how lncRNAs acquire properties as biological signal transducers and hint at their possible origins in evolution.
Widespread Shortening of 3 0 UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells
Christine Mayr,David P. Bartel +1 more
TL;DR: The high incidence of APA in cancer cells, with consequent loss of 3'UTR repressive elements, suggests a pervasive role forAPA in oncogene activation without genetic alteration.