Journal ArticleDOI
Alternative splicing in the control of gene expression
Reads0
Chats0
TLDR
In this review, the discussion of mechanisms attempts to be exhaustive, drawing not only upon direct experimental investigations of alternatively spliced genes, but also upon relevant themes derived from the study of constitutive splicing.Abstract:
In this review, we focus upon the mechanistic, functional, and evolutionary aspects of alternative splicing. The discussion of mechanisms attempts to be exhaustive, drawing not only upon direct experimental investigations of alternatively spliced genes, but also upon relevant themes derived from the study of constitutive splicingread more
Citations
More filters
Journal ArticleDOI
A new variant of glycoprotein cd44 confers metastatic potential to rat carcinoma cells
U. Günthert,Martin Hofmann,Wolfgang Rudy,S. Reber,Margot Zöller,Irmgard U. Haussmann,S. Matzku,A. Wenzel,Helmut Ponta,Peter Herrlich +9 more
TL;DR: Using a monoclonal antibody raised against a surface glycoprotein of the metastasizing rat pancreatic carcinoma cell line BSp73ASML, cDNA clones have been isolated that encode glycoproteins with partial homology to CD44, a presumed adhesion molecule.
Journal ArticleDOI
EBSeq: an empirical Bayes hierarchical model for inference in RNA-seq experiments.
Ning Leng,John A. Dawson,James A. Thomson,Victor Ruotti,Anna I. Rissman,Bart M. G. Smits,Jill D. Haag,Michael N. Gould,Ron Stewart,Christina Kendziorski +9 more
TL;DR: EBSeq is developed, using the merits of empirical Bayesian methods, for identifying DE isoforms in an RNA-seq experiment comparing two or more biological conditions and proves to be a robust approach for identifying De genes.
Journal ArticleDOI
A protein tyrosine kinase in the interferon alpha/beta signaling pathway.
TL;DR: The genetic complementation of this mutant and the identification and cloning of the wild-type gene that corrects the defect are described and shows that tyk2 links the interferon alpha/beta receptor to the cytoplasmic transcription factor that mediates activation of interferons-responsive genes.
Journal ArticleDOI
SR proteins: a conserved family of pre-mRNA splicing factors.
TL;DR: It is demonstrated that four different proteins from calf thymus are able to restore splicing in the same splicing-deficient extract using several different pre-mRNA substrates, and a repeated protein sequence that encompasses an RNA recognition motif was observed.
Journal ArticleDOI
Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2
Akila Mayeda,Adrian R. Krainer +1 more
TL;DR: When messenger RNA precursors (pre-mRNAs) containing alternative 5' splice sites are spliced in vitro, the relative concentrations of the heterogeneous ribonucleoprotein (hnRNP) A1 and the essential splicing factor SF2 precisely determine which 5'splice site is selected.
References
More filters
Journal ArticleDOI
A catalogue of splice junction sequences
TL;DR: The sequence CAAG/GTAGAGT was found to be a consensus of 139 exon-intron boundaries (or donor sequences) and (TC)nNCTAG/G was found of 130 intron-exon boundaries ( or acceptor sequences).
Journal ArticleDOI
A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins
TL;DR: In this paper, two cDNAs were isolated whose dimerized products bind specifically to a DNA sequence, kappa E2, located in the immunoglobulin kappa chain enhancer.
Journal ArticleDOI
Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products
TL;DR: A model in which developmental regulation of RNA processing is used to increase the diversity of neuroendocrine gene expression is proposed.
Journal ArticleDOI
Transcription termination and 3' processing: the end is in site!
TL;DR: In this article, it was shown that 3' cleavage of pre-mRNA in eukaryotes is, in many ways, the phenotypic equivalent of transcription termi-nation.