Journal ArticleDOI
Amplification of pyridine nucleotide pools in mitogen-stimulated human lymphocytes
Nathan A. Berger,Nathan A. Berger,Sosamma J. Berger,Sosamma J. Berger,Georgina W. Sikorski,Georgina W. Sikorski,Donna M. Catino,Donna M. Catino +7 more
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TLDR
Human lymphocytes were able to synthesize pyridine nucleotides from nicotinamide or nicotinic acid but did not efficiently use tryptophan for the synthesis of NAD; these cells showed a marked increase in activity of the enzyme adenosine-triphosphate-nicotinamide mononucleotide (ATP-NMN) adenylyl transferase.About:
This article is published in Experimental Cell Research.The article was published on 1982-01-01. It has received 52 citations till now. The article focuses on the topics: NAD+ kinase & Nicotinamide.read more
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O6 alkylguanine-DNA alkyltransferase activity in human myeloid cells.
TL;DR: Human myeloid precursors have low levels of O6alkylguanine-DNA alkyltransferase compared with other tissues, and high levels of this DNA repair protein may increase the susceptibility of myeloids precursor to malignant transformation after exposure to certainAlkylating agents.
Journal ArticleDOI
Determination of metabolite and nucleotide concentrations in proliferating lymphocytes by 1H-NMR of acid extracts.
Daniel Y. Sze,Oleg Jardetzky +1 more
TL;DR: Changes in intracellular concentrations of lactate, taurine, inositol and nucleotides, including NAD, IMP and high-energy phosphates, were especially marked during the course of lymphocyte culture.
Journal ArticleDOI
Lymphocyte dysfunction after DNA damage by toxic oxygen species. A model of immunodeficiency.
TL;DR: Excessive poly(ADP-ribose) synthesis, provoked by DNA strand breakage, may represent a common pathway that connects the immunodeficiency syndromes associated with exposure of lymphocytes to toxic oxygen species during chronic inflammatory states, (b) adenosine deaminase deficiency, and (c) certain DNA repair disorders.
Journal ArticleDOI
Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system.
Haruhiro Higashida,Alla B. Salmina,Raissa Ya. Olovyannikova,Minako Hashii,Shigeru Yokoyama,Keita Koizumi,Duo Jin,Hong-Xiang Liu,Olga Lopatina,Sarwat Amina,Mohammad Saharul Islam,Jian-Jun Huang,Mami Noda +12 more
TL;DR: It is possible that pharmacological manipulation of intracellular cadPR levels through ADP-ribosyl cyclase activity or synthetic cADPR analogues may provide new therapeutic opportunities for treatment of neurodevelopmental disorders.
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Ferricyanide can replace pyruvate to stimulate growth and attachment of serum restricted human melanoma cells
Kay A.O. Ellem,G.F. Kay +1 more
TL;DR: Addition of potassium ferricyanide to RPMI 1640 medium can stimulate cell attachment and replication, in a closely correlated fashion, of a human melanoma line when serum is a limiting growth factor.
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(ADP-ribose)n participates in DNA excision repair.
TL;DR: It is demonstrated that one function of (ADP–ribose)n is to participate in the cellular recovery from DNA damage, and specific inhibitors of poly(ADP-ribose] polymerase prevent rejoining of DNA strand breaks caused by dimethyl sulphate and cytotoxicity is enhanced thereby.
Journal ArticleDOI
Poly(ADP-ribose) and ADP-ribosylation of proteins.
Osamu Hayaishi,K Ueda +1 more
TL;DR: This chapter analyzes poly(ADp-ribose) and ADP-ribosylation of proteins, a novel type of covalent modification of proteins that is implicated in the regulation of cell proliferation, protein synthesis, and DNA as well as RNA metabolism.