Journal ArticleDOI
An Integrated Study of Tyrosinase Inhibition by Rutin: Progress using a Computational Simulation
Yue-Xiu Si,Shang-Jun Yin,Sangho Oh,Zhi-Jiang Wang,Sen Ye,Li Yan,Jun-Mo Yang,Yong-Doo Park,Jinhyuk Lee,Guo-Ying Qian +9 more
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TLDR
The strategy of predicting tyrosinase inhibition based on hydroxyl group number and computational simulation may prove useful for the screening of potential tyrosIn inhibition studies and rutin has the potential to be a potent antipigment agent.Abstract:
Tyrosinase inhibition studies have recently gained the attention of researchers due to their potential application values We simulated docking (binding energies for AutoDock Vina: -91 kcal/mol) and performed a molecular dynamics simulation to verify docking results between tyrosinase and rutin The docking results suggest that rutin mostly interacts with histidine residues located in the active site A 10 ns molecular dynamics simulation showed that one copper ion at the tyrosinase active site was responsible for the interaction with rutin Kinetic analyses showed that rutin-mediated inactivation followed a first-order reaction and mono- and biphasic rate constants occurred with rutin The inhibition was a typical competitive type with K(i) = 110±025 mM Measurements of intrinsic and ANS-binding fluorescences showed that rutin showed a relatively strong binding affinity for tyrosinase and one possible binding site that could be a copper was detected accompanying with a hydrophobic exposure of tyrosinase Cell viability testing with rutin in HaCaT keratinocytes showed that no toxic effects were produced Taken together, rutin has the potential to be a potent anti-pigment agent The strategy of predicting tyrosinase inhibition based on hydroxyl group number and computational simulation may prove useful for the screening of potential tyrosinase inhibitorsread more
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Properties and applications of flavonoid metal complexes
TL;DR: In this paper, a broad spectrum of possible activities and potential applications of flavonoids coordinated to metal ions is discussed in order to give our readers a broad view on the topic of this class of compounds, their activity, and their potential applications.
Journal ArticleDOI
Plants from Brazilian Cerrado with Potent Tyrosinase Inhibitory Activity
Paula Monteiro Souza,Silvia Taveira Elias,Luiz Alberto Simeoni,José Elias de Paula,Sueli Maria Gomes,Eliete Neves Silva Guerra,Yris Maria Fonseca,Elton Clementino Silva,Dâmaris Silveira,Pérola Oliveira Magalhães +9 more
TL;DR: Results indicate that Pouteria torta and Eugenia dysenterica extracts and their isolated constituents are promising agents for skin-whitening or antimelanogenesis formulations.
Journal ArticleDOI
Rutin and ascorbic acid cooperation in antioxidant and antiapoptotic effect on human skin keratinocytes and fibroblasts exposed to UVA and UVB radiation
Agnieszka Gęgotek,Ewa Ambrożewicz,Anna Jastrząb,Iwona Jarocka-Karpowicz,Elżbieta Skrzydlewska +4 more
TL;DR: The results showed that rutin and ascorbic acid are complementary in their antioxidant actions, transport and signaling functions, and suggest they are a potentially cytoprotective team against UV-induced skin damage.
Journal ArticleDOI
Extracts of Morus nigra L. Leaves Standardized in Chlorogenic Acid, Rutin and Isoquercitrin: Tyrosinase Inhibition and Cytotoxicity.
Marcela Medeiros de Freitas,Pedro Ribeiro Fontes,Paula Monteiro Souza,Christopher William Fagg,Eliete Neves Silva Guerra,Yanna Karla de Medeiros Nóbrega,Dâmaris Silveira,Yris Maria Fonseca-Bazzo,Luiz Alberto Simeoni,Mauricio Homem-de-Mello,Pérola Oliveira Magalhães +10 more
TL;DR: The potential of M. nigra leaf extract as a promising whitening agent of natural source against skin hyperpigmentation is demonstrated, and tyrosinase inhibition is studied by extracts from Morus nigra leaves.
Journal ArticleDOI
Biological and chemical insights of Morina persica L.: A source of bioactive compounds with multifunctional properties
Andrei Mocan,Gokhan Zengin,Ahmet Uysal,Erdogan Gunes,Adriano Mollica,Nurdan Sena Degirmenci,Lokman Alpsoy,Abdurrahman Aktumsek +7 more
TL;DR: In this article, biological and chemical fingerprints of different extracts (methanolic, acetone and water) of M. persica L. were investigated for biological profiling, showing that methanolic and acetone extracts had strong antioxidant, enzyme inhibitory, antimicrobial and antimutagenic effects.
References
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AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
Oleg Trott,Arthur J. Olson +1 more
TL;DR: AutoDock Vina achieves an approximately two orders of magnitude speed‐up compared with the molecular docking software previously developed in the lab, while also significantly improving the accuracy of the binding mode predictions, judging by tests on the training set used in AutoDock 4 development.
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Kenno Vanommeslaeghe,Elizabeth Hatcher,Chayan Acharya,Sibsankar Kundu,Shijun Zhong,Jihyun Shim,Eva Darian,Olgun Guvench,Pedro E. M. Lopes,Igor Vorobyov,Alexander D. MacKerell +10 more
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