An Update on Oxidative Damage to Spermatozoa and Oocytes
Chinyerum S. Opuwari,Ralf Henkel +1 more
Reads0
Chats0
TLDR
Possible correctable measures include foremost lifestyle changes, but also supplementation with antioxidants to scavenge excessive ROS, but this should only be done after careful examination of the patient and establishment of the individual bodily antioxidant needs.Abstract:
On the one hand, reactive oxygen species (ROS) are mandatory mediators for essential cellular functions including the function of germ cells (oocytes and spermatozoa) and thereby the fertilization process. However, the exposure of these cells to excessive levels of oxidative stress by too high levels of ROS or too low levels of antioxidative protection will render these cells dysfunctional thereby failing the fertilization process and causing couples to be infertile. Numerous causes are responsible for the delicate bodily redox system being out of balance and causing disease and infertility. Many of these causes are modifiable such as lifestyle factors like obesity, poor nutrition, heat stress, smoking, or alcohol abuse. Possible correctable measures include foremost lifestyle changes, but also supplementation with antioxidants to scavenge excessive ROS. However, this should only be done after careful examination of the patient and establishment of the individual bodily antioxidant needs. In addition, other corrective measures include sperm separation for assisted reproductive techniques. However, these techniques have to be carried out very carefully as they, if applied wrongly, bear risks of generating ROS damaging the germ cells and preventing fertilization.read more
Citations
More filters
Journal ArticleDOI
Oxidative stress and sperm function: A systematic review on evaluation and management
TL;DR: OS is an important cause of male factor infertility and its assessment provides essential information that can guide treatment strategies aimed at improving the male’s reproductive potential.
Journal ArticleDOI
Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management
TL;DR: Physiological ROS production, roles of genetic and epigenetic factors on the OS and male infertility with various mechanisms such as lipid peroxidation, DNA damage, and disorder of male hormone profile, inflammation, and varicocele are described.
Journal ArticleDOI
Oxidative stress in biological systems and its relation with pathophysiological functions: the effect of physical activity on cellular redox homeostasis
TL;DR: The current state of knowledge on the association between oxidative stress and the pathogenesis of some characteristic to the biological systems diseases and aging process is summarised.
Journal ArticleDOI
The Importance of Oxidative Stress in Determining the Functionality of Mammalian Spermatozoa: A Two-Edged Sword.
TL;DR: The environmental and lifestyle factors that promote ROS generation by the spermatozoa are reviewed in this article, as are the techniques that might be used in a diagnostic context to identify patients whose reproductive capacity is under oxidative threat.
Journal ArticleDOI
From sperm to offspring: Assessing the heritable genetic consequences of paternal smoking and potential public health impacts.
TL;DR: The available evidence makes a compelling case that tobacco smoke is a human germ cell mutagen with serious public health and socio-economic implications, and increased public education should be encouraged to promote abstinence from smoking, well in advance of reproduction, to minimize the transmission of harmful mutations to the next-generation.
References
More filters
Journal ArticleDOI
A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V.
TL;DR: The Annexin V assay offers the possibility of detecting early phases of apoptosis before the loss of cell membrane integrity and permits measurements of the kinetics of apoptotic death in relation to the cell cycle.
Journal ArticleDOI
Increased oxidative stress in obesity and its impact on metabolic syndrome
Shigetada Furukawa,Takuya Fujita,Michio Shimabukuro,Masanori Iwaki,Yukio Yamada,Yoshimitsu Nakajima,Osamu Nakayama,Makoto Makishima,Morihiro Matsuda,Iichiro Shimomura +9 more
TL;DR: It is suggested that increased oxidative stress in accumulated fat is an early instigator of metabolic syndrome and that the redox state in adipose tissue is a potentially useful therapeutic target for obesity-associated metabolic syndrome.
Journal ArticleDOI
Role of oxidative stress in female reproduction
TL;DR: The role OS plays in normal cycling ovaries, follicular development and cyclical endometrial changes is reviewed and female infertility and how it influences the outcomes of assisted reproductive techniques is discussed.
Journal ArticleDOI
Lipid peroxidation—DNA damage by malondialdehyde
TL;DR: M1G appears to be a major endogenous DNA adduct in human beings that may contribute significantly to cancer linked to lifestyle and dietary factors and high throughput methods for its detection and quantitation will be extremely useful for screening large populations.
Journal ArticleDOI
Generation of reactive oxygen species, lipid peroxidation, and human sperm function.
TL;DR: Results are consistent with a causative role for lipid peroxidation in the etiology of defective sperm function and also suggest a possible physiological role for the reactive oxygen species generated by human spermatozoa in mediating sperm-zona interaction.