Journal ArticleDOI
Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management
TLDR
Physiological ROS production, roles of genetic and epigenetic factors on the OS and male infertility with various mechanisms such as lipid peroxidation, DNA damage, and disorder of male hormone profile, inflammation, and varicocele are described.Abstract:
Infertility is a global health problem involving about 15% of couples. Approximately half of the infertility cases are related to male factors. The oxidative stress, which refers to an imbalance in levels of reactive oxygen species (ROS) and antioxidants, is one of the main causes of infertility in men. A small amount of ROS is necessary for the physiological function of sperm including the capacitation, hyperactivation and acrosomal reaction. However, high levels of ROS can cause infertility through not only by lipid peroxidation or DNA damage but inactivation of enzymes and oxidation of proteins in spermatozoa. Oxidative stress (OS) is mainly caused by factors associated with lifestyle. Besides, immature spermatozoa, inflammatory factors, genetic mutations and altering levels of sex hormones are other main source of ROS. Since OS occurs due to the lack of antioxidants and its side effects in semen, lifestyle changes and antioxidant regimens can be helpful therapeutic approaches to overcome this problem. The present study aimed to describe physiological ROS production, roles of genetic and epigenetic factors on the OS and male infertility with various mechanisms such as lipid peroxidation, DNA damage, and disorder of male hormone profile, inflammation, and varicocele. Finally, the roles of oral antioxidants and herbs were explained in coping with OS in male infertility.read more
Citations
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Journal ArticleDOI
Reactive oxygen species in male reproduction: A boon or a bane?
TL;DR: The dual role of ROS in male reproduction is discussed, highlighting the physiological role as well as their pathological implications on male fertility.
Journal ArticleDOI
Oxidative Stress, Testicular Inflammatory Pathways, and Male Reproduction
TL;DR: In this article, the role of inflammation and oxidative stress in male infertility was investigated in detail, as well as the mechanistic pathways that link causative factors of male reproductive tract inflammation, OS induction, and oxidant-sensitive cellular cascades.
Journal ArticleDOI
Discovery of the Involvement in DNA Oxidative Damage of Human Sperm Nuclear Basic Proteins of Healthy Young Men Living in Polluted Areas.
Gennaro Lettieri,Giovanni D’Agostino,Elena Mele,Carolina Cardito,Rosa Esposito,Annalinda Cimmino,Antonella Giarra,Marco Trifuoggi,Salvatore Raimondo,Tiziana Notari,Ferdinando Febbraio,Luigi Montano,Marina Piscopo +12 more
TL;DR: All the sperm nuclear basic proteins from these samples that resulted were involved in DNA oxidative damage, supporting the idea that these proteins could promote the Fenton reaction in DNA proximity by increasing the availability of these metals near the binding surface of DNA.
Journal ArticleDOI
Mitochondria: Their relevance during oocyte ageing
TL;DR: In this paper, the authors describe the functions of mitochondria as bioenergetic powerhouses and signal transducers in oocytes, how dysfunction of mitochondrial processes contributes to reproductive ageing, and whether mitochondria could be targeted to promote oocyte rejuvenation.
Journal ArticleDOI
Mitochondrial Reactive Oxygen Species (ROS) Production Alters Sperm Quality.
TL;DR: In this paper, the impact of reactive oxygen species (ROS) at multiple levels in sperm: the genome, proteome, lipidome, epigenome, and epigenome was discussed.
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