Anthrax sub-unit vaccine: the structural consequences of binding rPA83 to Alhydrogel®.
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TLDR
It is suggested that antigen destabilisation is not a primary mechanism of Alhydrogel adjuvancy and informative structural characterisation is possible for adjuvant bound sub-unit vaccines.About:
This article is published in European Journal of Pharmaceutics and Biopharmaceutics.The article was published on 2012-01-01 and is currently open access. It has received 16 citations till now. The article focuses on the topics: Anthrax vaccines.read more
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Vaccine delivery using nanoparticles
TL;DR: N nanoscale size materials such as virus-like particles, liposomes, ISCOMs, polymeric, and non-degradable nanospheres have received attention as potential delivery vehicles for vaccine antigens which can both stabilize vaccine antIGens and act as adjuvants, thereby modulating the immune response to the antigen.
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Mechanism of immunopotentiation and safety of aluminum adjuvants
TL;DR: Aluminum-containing adjuvants are widely used in preventive vaccines against infectious diseases and in preparations for allergy immunotherapy and the mechanism by which they enhance the immune response remains poorly understood.
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Polyionic vaccine adjuvants: another look at aluminum salts and polyelectrolytes.
TL;DR: The genesis of adjuvant technology is surveyed and then re-examines polyionic macromolecules and polyelectrolyte materials, adjuvants currently not known to employ TLR, as examples of improvements to the oldest and emerging classes of vaccine adjuvant in use.
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Recombinant protein subunit vaccine synthesis in microbes: a role for yeast?
TL;DR: The benefits of using yeast as the recombinant host for recombinant protein subunit vaccines are highlighted.
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Structural and Immunological Analysis of Anthrax Recombinant Protective Antigen Adsorbed to Aluminum Hydroxide Adjuvant
Leslie D Wagner,Anita Verma,Bruce D. Meade,Karine Reiter,David L. Narum,Rebecca A. Brady,Stephen F. Little,Drusilla L. Burns +7 more
TL;DR: It is demonstrated that storage of rPA-Alhydrogel formulations can lead to structural alteration of the protein and loss of the ability to elicit toxin-neutralizing antibodies.
References
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Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion.
TL;DR: The results of the model compound study provide evidence for a mechanism that follows the classical Stern-Volmer law (1919), predominantly involving collisional quenching, and illustrate the importance of local charge and solvent viscosity.
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Protein structure : a practical approach
TL;DR: See: Estimating molecular weights of polypeptides by SDS gel electrophoresis Righetti: Isoelectric focusing of proteins in conventional and immobilized pH gradients.
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Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells
Mirjam Kool,Thomas Soullié,Menno van Nimwegen,Monique Willart,Femke Muskens,Steffen Jung,Henk C. Hoogsteden,Hamida Hammad,Bart N. Lambrecht +8 more
TL;DR: Mechanistically, DC-driven responses were abolished in MyD88-deficient mice and after uricase treatment, implying the induction of uric acid, and suggest that alum adjuvant is immunogenic by exploiting “nature's adjUvant,” the inflammatory DC through induction of the endogenous danger signal uric acids.