Journal ArticleDOI
Anti-inflammatory and antitumoural effects of Uncaria guianensis bark
TLDR
Ug AIV was not cytotoxic for tumour cells or macrophages, and its anti-tumour effect may be due to a reduction in pro-Tumoural inflammatory processes in the tumour microenvironment, possibly mediated through NF-κB.About:
This article is published in Journal of Ethnopharmacology.The article was published on 2013-12-12. It has received 13 citations till now. The article focuses on the topics: Uncaria guianensis & Lipopolysaccharide.read more
Citations
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Journal Article
Bioactive Compounds from Plants Used in Peruvian Traditional Medicine.
TL;DR: This paper makes a review of the botanical, chemical, pharmacological and clinical propierties of the most investigated Peruvian medicinal plants.
Journal ArticleDOI
Unnatural spirocyclic oxindole alkaloids biosynthesis in Uncaria guianensis
Adriana A. Lopes,Bianca Chioca,Bruno Musquiari,Eduardo J. Crevelin,Suzelei C. França,Maria Fátima das Graças Fernandes da Silva,Ana Maria Soares Pereira +6 more
TL;DR: A precursor-directed biosynthesis approach was carried out with U. guianensis and successfully obtained oxindole alkaloid analogues with molecular mass corresponding to the addition of a methyl or fluorine group on the oxindoles ring using tryptamine analogue precursors.
Ecología, manejo y aprovechamiento sustentable de la uña de gato (Uncaria guianensis (Aublet) y Uncaria tomentosa (Willd.) D.C) en comunidades Tikuna del sur de la Amazonia colombiana
Garzón Garzón,Lina Paola +1 more
TL;DR: In this article, the authors investigate the use and manejo of una gato in the area of Tikuna, a region amazonica in the Amazonia colombiana, in which U. guianensis and Uncaria tomentosa exist.
Journal ArticleDOI
The search for plants with anticancer activity: pitfalls at the early stages.
Peter Taylor,L. Colman,J. Bajoon +2 more
TL;DR: Using both theoretical considerations and experimental data, this work questions the frequent overinterpretation of reported results regarding the selectivity for cancer cells of the plant extract or compound under study, concluding that this "selectivity" is due to a quantitative difference in cell proliferation rates, rather than a qualitative difference between normal and tumour cells.
Journal ArticleDOI
Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-κB and MAPK in macrophages
Xianjun Yu,Xianjun Yu,Qun Zhao,Haiwei Zhang,Cunxian Fan,Xixi Zhang,Qun Xie,Qun Xie,Chengxian Xu,Yongbo Liu,Xiaoxia Wu,Quanbin Han,Haibing Zhang +12 more
TL;DR: Results indicate that GEA could suppress LPS-simulated inflammatory response partially by attenuating NO synthesis and NF-κB and MAPK activation, suggesting that it may become a potent therapeutic agent for the treatment of inflammatory diseases.
References
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Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
Journal ArticleDOI
Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
Journal ArticleDOI
Sulforhodamine B colorimetric assay for cytotoxicity screening
TL;DR: The sulforhodamine B (SRB) assay is used for cell density determination, based on the measurement of cellular protein content, which is an efficient and highly cost-effective method for screening.
Journal ArticleDOI
NF-kappaB: linking inflammation and immunity to cancer development and progression.
Michael Karin,Florian R. Greten +1 more
TL;DR: The hypothesis is put forward that activation of nuclear factor-κB by the classical, IKK-β (inhibitor-of-NF-β kinase-β)-dependent pathway is a crucial mediator of inflammation-induced tumour growth and progression, as well as an important modulator of tumour surveillance and rejection.
Journal ArticleDOI
Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis
TL;DR: Macrophages within the tumor microenvironment facilitate angiogenesis and extracellular-matrix breakdown and remodeling and promote tumor cell motility and are an important drug target for cancer therapy.
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