Journal ArticleDOI
Anti-inflammatory effect of Ishige okamurae ethanolic extract via inhibition of NF-kappaB transcription factor in RAW 264.7 cells.
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TLDR
It is found for the first time that ethanolic extract of Ishige okamurae (IO) classified into brown algae was effective in inhibiting the production of inflammatory mediators, such as tumor necrosis factor‐α, interleukin‐1β, Interleuk in‐6 and prostaglandin E2, in RAW264.Abstract:
Nowadays, much attention has been paid to the development of anti-inflammatory agents from marine natural resources. As a result of screening anti-inflammatory agents from marine algae using immunoassay, we found for the first time that ethanolic extract of Ishige okamurae (IO) classified into brown algae was effective in inhibiting the production of inflammatory mediators, such as tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 and prostaglandin E(2), in RAW264.7 cells stimulated by lipopolysaccharide, compared with dexamethasone and aspirin used as positive control in this study. Moreover, transcriptional activation of NF-kappaB transcription factor that regulates the expression of these inflammatory mediators was also examined using reporter gene assay and western blot analysis. It was observed that IO extract exerted anti-inflammatory effect via inactivation of NF-kappaB transcription factor in macrophages. In addition, the expression and activity of matrix metalloproteinase-2 and 9 that play an important role in chronic inflammation were decreased in dose-dependent manner in the presence of IO extract in HT1080 cells. The above results suggest that IO extract can inhibit inflammation through inactivation of NF-kappaB transcription factor in macrophage.read more
Citations
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Marine Pharmacology in 2009–2011: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and other Miscellaneous Mechanisms of Action
TL;DR: The peer-reviewed marine pharmacology literature from 2009 to 2011 is presented in this review, following the format used in the 1998–2008 reviews, and the pharmacology of structurally-characterized compounds isolated from marine animals, algae, fungi and bacteria is discussed in a comprehensive manner.
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Marine algal natural products with anti-oxidative, anti-inflammatory, and anti-cancer properties
Jin-Ching Lee,Ming-Feng Hou,Hurng-Wern Huang,Fang Rong Chang,Chi Chen Yeh,Jen Yang Tang,Hsueh-Wei Chang +6 more
TL;DR: This mini-review comprehensively compares the bioactivities and biological functions of biomaterials from red, green, brown, and blue-green algae to find potential for use in anti-cancer and anti-inflammatory drugs.
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Neuroprotective Effects of Marine Algae
Ratih Pangestuti,Se-Kwon Kim +1 more
TL;DR: An overview of marine algal neuroprotective effects and their potential application in neuroprotection is presented.
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Therapeutic Potential and Health Benefits of Sargassum species
TL;DR: This review paper explores the current knowledge of phytochemical, therapeutic potential, and health benefits of different species of genus Sargassum and finds great potential to be used in pharmaceutical and neutralceutical areas.
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Seafood consumption and components for health.
TL;DR: In this paper, a review on the components derived from seafood and examines the significant role they play in the maintenance and promotion of health, including protein, amino acids, fiber, vitamins, and minerals.
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