Antiangiogenic Cancer Therapy: Monitoring with Molecular US and a Clinically Translatable Contrast Agent (BR55)
Marybeth A. Pysz,Kira Foygel,Jarrett Rosenberg,Sanjiv S. Gambhir,Michel Schneider,Jürgen K. Willmann +5 more
TLDR
Human MB(KDR) allow in vivo imaging and longitudinal monitoring of VEGFR2 expression in human colon cancer xenografts and in vivo receptor blocking with anti-VEGFR2 antibody is tested.Abstract:
Clinically translatable human kinase insert domain receptor–targeted contrast microbubbles can be designed and successfully used for in vivo molecular US of vascular endothelial growth factor receptor 2 in the tumor vasculature in mice.read more
Citations
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Molecular Imaging: Current Status and Emerging Strategies
TL;DR: Current preclinical findings and advances in instrumentation suggest that these molecular imaging methods have numerous potential clinical applications and will be translated into clinical use in the near future.
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Applications of nanoparticles for diagnosis and therapy of cancer
TL;DR: Applications of diagnostic and therapeutic nanoparticles are presented, frequently used non-invasive imaging techniques are summarized and the role of EPR in the accumulation of nanotheranostic formulations is described.
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Molecular ultrasound imaging: current status and future directions
TL;DR: Current concepts and future directions of molecular ultrasound imaging are reviewed, including different classes of molecular ultrasounds contrast agents, ongoing technical developments of pre-clinical and clinical ultrasound systems, the potential of Molecular ultrasound for imaging different diseases at the molecular level, and the translation of molecular Ultrasound into the clinic.
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Ultrasound Microbubbles for Molecular Diagnosis, Therapy, and Theranostics
TL;DR: A review on the use of microbubbles for ultrasound-based molecular imaging, therapy, and theranostics addresses innovative concepts and identifies areas in which clinical translation is foreseeable in the near future.
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Molecular imaging for cancer diagnosis and surgery
Timon Hussain,Quyen T. Nguyen +1 more
TL;DR: A truly theranostic approach with the further addition of therapeutic agents to the molecular probe for adjuvant therapy is conceivable for the future.
References
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The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
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Tumorigenesis and the angiogenic switch
TL;DR: A more detailed understanding of the complex parameters that govern the interactions between the tumour and vascular compartments will help to improve anti-angiogenic strategies — not only for cancer treatment, but also for preventing recurrence.
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Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis
Daniel J. Hicklin,Lee M. Ellis +1 more
TL;DR: Recently, an anti-VEGF antibody (bevacizumab), when used in combination with chemotherapy, was shown to significantly improve survival and response rates in patients with metastatic colorectal cancer and thus, validate VEGF pathway inhibitors as an important new treatment modality in cancer therapy.
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Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
TL;DR: The recent approval of bevacizumab by the US FDA as a first-line therapy for metastatic colorectal cancer validates the ideas that VEGF is a key mediator of tumour angiogenesis and that blockingAngiogenesis is an effective strategy to treat human cancer.
Journal ArticleDOI
High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis.
Birgit Millauer,Susanne Wizigmann-Voos,Harald Schnürch,Ricardo Martinez,Niels Møller,Werner Risau,Axel Ullrich +6 more
TL;DR: Investigation of flk-1 receptor tyrosine kinase mRNA expression by in situ hybridization analysis revealed specific association with endothelial cells at all stages of mouse development, suggesting a major role of this ligand-receptor signaling system in vasculogenesis and angiogenesis.