Journal ArticleDOI
Antioxidant defense in rat brain after chronic treatment with anorectic drugs
Vânia D'Almeida,Rosana Camarini,Ligia Ajaime Azzalis,Rita Mattei,Virgínia Berlanga Campos Junqueira,Elisaldo Araujo Carlini +5 more
TLDR
It is concluded that the chronic administration of mazindol and methamphetamine have no effects on the antioxidant systems studied either in young (10 months) or in old (23 months) rats.About:
This article is published in Toxicology Letters.The article was published on 1995-11-15. It has received 17 citations till now. The article focuses on the topics: Mazindol & Anorectic.read more
Citations
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Methamphetamine toxicity and messengers of death
Irina N. Krasnova,Jean Lud Cadet +1 more
TL;DR: The accumulated evidence indicates that multiple events converge to mediate METH-induced terminal degeneration and neuronal apoptosis, and suggest that pharmacological strategies geared towards the prevention and treatment of the deleterious effects of this drug will need to attack the various pathways that form the substrates of METH toxicity.
Journal Article
Effects of lithium and valproate on amphetamine-induced oxidative stress generation in an animal model of mania
Benicio N. Frey,Samira S. Valvassori,Gislaine Z. Réus,Márcio R. Martins,Fabricia Petronilho,Katrine Bardini,Felipe Dal-Pizzol,Flávio Kapczinski,João Quevedo +8 more
TL;DR: The findings suggest that lithium and valproate exert protective effects against amphetamine-induced oxidative stress in vivo, further supporting the hypothesis that oxidative stress may be associated with the pathophysiology of BD.
Journal ArticleDOI
Changes in Antioxidant Defense Enzymes after d- amphetamine Exposure: Implications as an Animal Model of Mania
Benicio N. Frey,Benicio N. Frey,Samira S. Valvassori,Gislaine Z. Réus,Márcio R. Martins,Fabricia Petronilho,Katrine Bardini,Felipe Dal-Pizzol,Flávio Kapczinski,João Quevedo +9 more
TL;DR: The findings suggest that amphetamine exposure is associated with an imbalance between SOD and CAT activity in the prefrontal cortex, hippocampus and striatum, in a rodent model of mania.
Journal ArticleDOI
Brain antioxidant systems in human methamphetamine users.
Anna Mirecki,Paul S. Fitzmaurice,Lee Ang,Kathryn S. Kalasinsky,Frank J. Peretti,Sally S. Aiken,Dennis J. Wickham,Allan L. Sherwin,José N. Nobrega,Henry Jay Forman,Stephen J. Kish +10 more
TL;DR: The data suggest that brain levels of many antioxidant systems are preserved in methamphetamine users and that GSH depletion, commonly observed during severe oxidative stress, might occur only with severe dopamine loss.
Journal ArticleDOI
Absence of oxidative stress following paradoxical sleep deprivation in rats.
Vânia D'Almeida,Débora Cristina Hipólide,Ligia Ajaime Azzalis,Letı́cia L Lobo,Virgínia Berlanga Campos Junqueira,Sergio Tufik +5 more
TL;DR: In this article, paradoxical sleep deprivation was performed on rats using platform technique to investigate the oxidative process associated with it, and the results suggest that sleep deprivation per se is not associated with oxidative damage.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more
TL;DR: The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.
Journal ArticleDOI
Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues
TL;DR: The use of the foregoing analytical method in the determination of total and oxidized glutathione contents of rat blood, kidney, and liver gave values in good agreement with those obtained by previous investigators.
Journal ArticleDOI
The aging process
TL;DR: It is not unreasonable to expect on the basis of present data that the healthy life span can be increased by 5-10 or more years by keeping body weight down, at a level compatible with a sense of well-being, while ingesting diets adequate in essential nutrients but designed to minimize random free radical reactions in the body.
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Methamphetamine-induced neuronal damage: a possible role for free radicals.
M.J. De Vito,George C. Wagner +1 more