Applications of stem cells and bioprinting for potential treatment of diabetes
TLDR
This review emphasizes on the applicability of employing both stem cells and other cells in 3D bioprinting to generate substitutes for diseased β-cells and recover lost pancreatic functions.Abstract:
Currently, there does not exist a strategy that can reduce diabetes and scientists are working towards a cure and innovative approaches by employing stem cell-based therapies. On the other hand, bioprinting technology is a novel therapeutic approach that aims to replace the diseased or lost β-cells, insulin-secreting cells in the pancreas, which can potentially regenerate damaged organs such as the pancreas. Stem cells have the ability to differentiate into various cell lines including insulin-producing cells. However, there are still barriers that hamper the successful differentiation of stem cells into β-cells. In this review, we focus on the potential applications of stem cell research and bioprinting that may be targeted towards replacing the β-cells in the pancreas and may offer approaches towards treatment of diabetes. This review emphasizes on the applicability of employing both stem cells and other cells in 3D bioprinting to generate substitutes for diseased β-cells and recover lost pancreatic functions. The article then proceeds to discuss the overall research done in the field of stem cell-based bioprinting and provides future directions for improving the same for potential applications in diabetic research.read more
Citations
More filters
Proceedings Article
Direct Laser Writing of 3D scaffolds for neural tissue engineering applications
Vasileia Melissinaki,A.A. Gill,Ilida Ortega,Maria Vamvakaki,Anthi Ranella,Costas Fotakis,Maria Farsari,Frederik Claeyssens +7 more
TL;DR: In this paper, the authors report on the fabrication of high resolution 3D scaffolds of polylactide-based materials using direct laser writing and explore their use as neural tissue engineering scaffolds.
Journal ArticleDOI
Automation, Monitoring, and Standardization of Cell Product Manufacturing
Meletios-Nikolaos Doulgkeroglou,Alessia Di Nubila,Bastian Niessing,Niels König,Robert Schmitt,Jackie Damen,Stephen J. Szilvassy,Wing Chang,Lynn Csontos,Sharon A. Louis,Patrick Kugelmeier,Vincent Ronfard,Yves Bayon,Dimitrios I. Zeugolis +13 more
TL;DR: Automation, monitoring and standardization should be considered at the early stages of the developmental cycle of cell products to deliver more robust and effective therapies and treatment plans to the bedside, reducing healthcare expenditure and improving services and patient care.
Journal ArticleDOI
Shaping Pancreatic β-Cell Differentiation and Functioning: The Influence of Mechanotransduction
A. Galli,Marku Algerta,P. Marciani,Carsten Schulte,Cristina Lenardi,Paolo Milani,Elisa Maffioli,Gabriella Tedeschi,Carla Perego +8 more
TL;DR: Although the regulatory mechanisms remain poorly understood, the analysis reveals that β-cells are equipped with all mechanosensors and signaling proteins actively involved in mechanotransduction in other cell types, and they respond to mechanical cues by changing their behavior.
Journal ArticleDOI
A Brief Review on 3D Bioprinted Skin Substitutes
TL;DR: The recent developments in 3D biopprinting for skin regeneration are reviewed to discuss different aspects of skin bioprinted substitutes, including 3D printing technology, bioink composition, and cell-laden constructs.
Journal ArticleDOI
Small Molecule-Induced Pancreatic β-Like Cell Development: Mechanistic Approaches and Available Strategies.
TL;DR: Basic concepts of pancreatic organogenesis are presented, which intermittently provides a basis for engineering differentiation procedures, mainly based on the use of small molecules, which offer immense benefits in terms of generating efficient functional beta-like cells.
References
More filters
Journal ArticleDOI
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
TL;DR: Induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions is demonstrated and iPS cells, designated iPS, exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
Journal ArticleDOI
Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
Journal ArticleDOI
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
Massimo Dominici,K. Le Blanc,Ingo Mueller,I. Slaper-Cortenbach,Frank C. Marini,Diane S. Krause,Robert J. Deans,Armand Keating,Darwin J. Prockop,Edwin M. Horwitz +9 more
TL;DR: The Mesenchymal and Tissue Stem Cell Committee of the International Society for Cellular Therapy proposes minimal criteria to define human MSC, believing this minimal set of standard criteria will foster a more uniform characterization of MSC and facilitate the exchange of data among investigators.
Journal ArticleDOI
Diagnosis and Classification of Diabetes Mellitus
TL;DR: The chronic hyperglycemia of diabetes is associated with long-term damage, dys-function, and failure of differentorgans, especially the eyes, kidneys, nerves, heart, and blood vessels.
Journal ArticleDOI
Projections of Global Mortality and Burden of Disease from 2002 to 2030
Colin Mathers,Dejan Loncar +1 more
TL;DR: These projections represent a set of three visions of the future for population health, based on certain explicit assumptions, which enable us to appreciate better the implications for health and health policy of currently observed trends, and the likely impact of fairly certain future trends.