Are Human P[14] Rotavirus Strains the Result of Interspecies Transmissions from Sheep or Other Ungulates That Belong to the Mammalian Order Artiodactyla?
Jelle Matthijnssens,Christiaan A. Potgieter,Max Ciarlet,Viviana Parreño,Vito Martella,Krisztián Bányai,Lorena Garaicoechea,Enzo A. Palombo,Luis Novo,Mark Zeller,Serenella Arista,Giuseppe Gerna,Mustafizur Rahman,Mustafizur Rahman,Marc Van Ranst +14 more
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TLDR
The genotype and phylogenetic analyses strongly suggest a common origin for the human P[14] strains and those of the even-toed ungulates belonging to the mammalian order Artiodactyla, with sheep probably playing a key role in the interspecies transmission responsible for the introduction of P[ 14] rotavirus strains into the human population.Abstract:
A limited number of human G6P[14] rotavirus strains that cause gastroenteritis in humans have been isolated in Europe and Australia. The complete genome sequences were determined for five of these human strains—B10925-97 (isolated in Belgium in 1997), 111/05-27 (Italy, 2005), PA169 (Italy, 1987), MG6 (Australia, 1993), and Hun5 (Hungary, 1997)—and their genetic relatedness to animal rotavirus strains was evaluated by sequencing the complete genome of the sheep rotavirus OVR762 (G8P[14]; Spain, 2002), the guanaco (Lama guanicoe) rotavirus strains Arg/Chubut/99 and Arg/Rio Negro/98 (G8P[14] and G8P[1], respectively; Argentina, 1999 and 1998), the sable antelope strain RC-18/08 (G6P[14]; South Africa, 2008), and the bovine rotavirus strain Arg/B383/98 (G15P[11]; Argentina, 1998). These analyses revealed an overall consensus genomic constellation (G6/G8)-P[14]-I2-(R2/R5)-C2-M2-(A3/A11)-N2-T6-(E2/E12)-H3, together with a few gene reassortments, and the phylogenetic analyses confirmed that the P[14] human strains evaluated in this study were closely related to rotavirus strains isolated from sheep, cattle, goats, guanacos, and antelopes and to rabbits (albeit to a lesser extent), suggesting that one (or more) of these animal species might be the source of the human G6P[14] strains. The main feature of the genotype and phylogenetic analyses was the close overall genomic relatedness between the five human G6P[14] rotavirus strains and the ovine and antelope rotavirus strains. Taken together, these data strongly suggest a common origin for the human P[14] strains and those of the even-toed ungulates belonging to the mammalian order Artiodactyla, with sheep probably playing a key role in the interspecies transmission responsible for the introduction of P[14] rotavirus strains into the human population.read more
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Uniformity of rotavirus strain nomenclature proposed by the Rotavirus Classification Working Group (RCWG).
Jelle Matthijnssens,Max Ciarlet,Sarah M. McDonald,Houssam Attoui,Krisztián Bányai,J. Rodney Brister,Javier Buesa,Mathew D. Esona,Mary K. Estes,Jon R. Gentsch,Miren Iturriza-Gomara,Reimar Johne,Carl D. Kirkwood,Vito Martella,Peter P. C. Mertens,Osamu Nakagomi,Viviana Parreño,Mustafizur Rahman,Franco Maria Ruggeri,Linda J. Saif,Norma Santos,Andrej Steyer,Koki Taniguchi,John T. Patton,Ulrich Desselberger,Marc Van Ranst +25 more
TL;DR: With increasing numbers of complete RV genome sequences becoming available, a standardized RV strain nomenclature system is needed, and the RCWG proposes that individual RV strains are named as follows: RV group/species of origin/country of identification/common name/year of identification /G- and P-type.
Journal ArticleDOI
Zoonotic aspects of rotaviruses
TL;DR: Genetic heterogeneity in the 11 double stranded RNA segments across different rotavirus strains has provided evidence for frequent intersections between the evolution of human and animal rotaviruses, as a result of multiple, repeated events of interspecies transmission and subsequent adaptation.
Journal ArticleDOI
Rotavirus disease and vaccination: impact on genotype diversity.
Jelle Matthijnssens,Joke Bilcke,Max Ciarlet,Vito Martella,Krisztián Bányai,Mustafizur Rahman,Mark Zeller,Philippe Beutels,Pierre Van Damme,Marc Van Ranst +9 more
TL;DR: It appears that the total number of hospitalizations due to rotavirus infections is being reduced, at least in developed countries that implemented a universal immunization program, however, continued surveillance is warranted, especially regarding the long-term effects of the vaccines.
Journal ArticleDOI
Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen
Liya Hu,Sue E. Crawford,Rita Czakó,Nicolas W. Cortes-Penfield,David L. Smith,Jacques Le Pendu,Mary K. Estes,B. V. Venkataram Prasad +7 more
TL;DR: It is shown that VP8* of a human rotavirus strain specifically recognizes A-type histo-blood group antigen (HBGA) using a glycan array screen comprised of 511 glycans, and that virus infectivity in HT-29 cells is abrogated by anti-A-type antibodies as well as significantly enhanced in Chinese hamster ovary cells genetically modified to express the A- type HBGA.
Journal ArticleDOI
Genotype constellation and evolution of group A rotaviruses infecting humans.
TL;DR: The overall genetic diversity of epidemiologically widespread human RVA strains is more limited than generally assumed and has consequences for how to look at host range restriction and the criteria according to which the effectiveness of RVA universal mass vaccination programs is assessed.
References
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Full Genome-Based Classification of Rotaviruses Reveals a Common Origin between Human Wa-Like and Porcine Rotavirus Strains and Human DS-1-Like and Bovine Rotavirus Strains
Jelle Matthijnssens,Max Ciarlet,Erica Heiman,Ingrid Arijs,Thomas Delbeke,Sarah M. McDonald,Enzo A. Palombo,Miren Iturriza-Gomara,Piet Maes,John T. Patton,Mustafizur Rahman,Mustafizur Rahman,Marc Van Ranst +12 more
TL;DR: The novel classification system allows the identification of (i) distinct genotypes, which probably followed separate evolutionary paths; (ii) interspecies transmissions and a plethora of reassortment events; and (iii) certain gene constellations that revealed a common origin between human Wa-like rotavirus strains and porcine rotav virus strains.
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