Journal ArticleDOI
Association of interleukin-15 protein and interleukin-15 receptor genetic variation with resistance exercise training responses
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TLDR
It is suggested that IL-15 is an important mediator of muscle mass response to resistance exercise training in humans and that genetic variation in IL15RA accounts for a significant proportion of the variability in this response.Abstract:
Interleukin-15 (IL-15) is an anabolic cytokine that is produced in skeletal muscle and directly affects muscle anabolism in animal and in vitro models. The contribution of IL-15 variability in musc...read more
Citations
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Muscle as an endocrine organ: focus on muscle-derived interleukin-6.
TL;DR: This review focuses on the myokine IL-6, its regulation by exercise, its signaling pathways in skeletal muscle, and its role in metabolism in both health and disease.
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The human gene map for performance and health-related fitness phenotypes: the 2005 update.
Molly S. Bray,James M. Hagberg,Louis Pérusse,Tuomo Rankinen,Stephen M. Roth,Bernd Wolfarth,Claude Bouchard +6 more
TL;DR: This review presents the 2002 update of the human gene map for physical performance and health-related phenotypes, based on peer-reviewed papers published by the end of 2002 and includes association studies with candidate genes, genome-wide scans with polymorphic markers, and single gene defects causing exercise intolerance to variable degrees.
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Role of myokines in exercise and metabolism.
TL;DR: The present review focuses on muscle-derived cytokines, their regulation by exercise, and their possible roles in metabolism and skeletal muscle function and it discusses which cytokines should be classified as true myokines.
Journal ArticleDOI
Exercise is the Real Polypill
TL;DR: In this article, a review summarizes the current body of knowledge on the main biological mediators (ingredients) of the preventive/therapeutic effects of regular exercise, and summarizes their roles.
Journal ArticleDOI
Time course of proteolytic, cytokine, and myostatin gene expression after acute exercise in human skeletal muscle
TL;DR: The timing of the gene induction indicated early elevation of proteolytic genes, followed by prolonged elevation of cytokines and suppression of myostatin during and after an acute bout of resistance (RE) or run (RUN) exercise.
References
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Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor
Kenneth H. Grabstein,June R. Eisenman,Kurt D. Shanebeck,Charles Rauch,Subhashini Srinivasan,Victor Fung,Courtney Beers,Jane S. Richardson,Michael A. Schoenborn,Minoo Ahdieh,Lisabeth Johnson,Mark R. Alderson,James D. Watson,Dirk M. Anderson,Judith G. Giri +14 more
TL;DR: A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated, indicating that IL-15 uses components of the IL-2 receptor.
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Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study.
Marjolein Visser,Marco Pahor,Dennis R. Taaffe,Bret H. Goodpaster,Eleanor M. Simonsick,Anne B. Newman,Michael C. Nevitt,Tamara B. Harris +7 more
TL;DR: Higher plasma concentrations of IL-6 and TNF-alpha are associated with lower muscle mass and lower muscle strength in well-functioning older men and women, and may contribute to the loss of Muscle mass and strength that accompanies aging.