Autopsy findings in COVID-19-related deaths: a literature review
Aniello Maiese,Alice Chiara Manetti,Raffaele La Russa,Marco Di Paolo,Emanuela Turillazzi,Paola Frati,Vittorio Fineschi +6 more
TLDR
It appears that there is a high incidence of deep vein thrombosis and pulmonary embolism among COVID-19 decedents, suggesting endothelial involvement, but more studies are needed.Citations
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series
Benjamin T. Bradley,Heather Maioli,Robert Johnston,Irfan Chaudhry,Susan L. Fink,Haodong Xu,Behzad Najafian,Gail H. Deutsch,J Matthew Lacy,Timothy L. Williams,Nicole A. Yarid,Desiree A. Marshall +11 more
TL;DR: A clinicopathological report of severe COVID-19 cases by documenting histopathological changes and evidence of SARS-CoV-2 tissue tropism is provided.
Journal ArticleDOI
Severe covid-19 pneumonia: pathogenesis and clinical management.
TL;DR: In this article, high flow nasal cannula (HFNC) was used to avoid intubation in acute respiratory distress syndrome (CARDS) patients with severe SARS CoV-2 infection.
Journal ArticleDOI
Pathophysiology of SARS-CoV-2: the Mount Sinai COVID-19 autopsy experience.
Clare Bryce,Zachary Grimes,Elisabet Pujadas,Sadhna Ahuja,Mary Beth Beasley,Randy A. Albrecht,Tahyna Hernandez,Aryeh Stock,Zhen Zhao,Mohamed Rizwan AlRasheed,Joyce Chen,Li Li,Diane Wang,Adriana D. Corben,G. Kenneth Haines,William H. Westra,Melissa Umphlett,Ronald E. Gordon,Jason Reidy,Bruce Petersen,Fadi Salem,Maria Isabel Fiel,Siraj M. El Jamal,Nadejda M. Tsankova,Jane Houldsworth,Zarmeen Mussa,Brandon Veremis,Emilia Mia Sordillo,Melissa R. Gitman,Michael D. Nowak,Rachel Brody,Noam Harpaz,Miriam Merad,Sacha Gnjatic,Wen-Chun Liu,Michael Schotsaert,Lisa Miorin,Teresa A. Aydillo Gomez,Irene Ramos-Lopez,Adolfo García-Sastre,Ryan Donnelly,Patricia Seigler,Calvin Keys,Jennifer Cameron,Isaiah Moultrie,Kae Lynn Washington,Jacquelyn D. Treatman,Robert Sebra,Jeffrey S. Jhang,Adolfo Firpo,John A. Lednicky,Alberto Paniz-Mondolfi,Carlos Cordon-Cardo,Mary Fowkes +53 more
TL;DR: The first 100 COVID-19-positive autopsies performed at the Mount Sinai Hospital in New York City revealed large pulmonary emboli in six cases and diffuse alveolar damage was present in over 90% of cases as mentioned in this paper.
Journal ArticleDOI
The pulmonary pathology of COVID-19.
TL;DR: The lung is the main affected organ in severe coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2, and lung damage is the leading cause of death in the vast majority of patients.
References
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Journal ArticleDOI
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
Alessandro Liberati,Douglas G. Altman,Jennifer Tetzlaff,Cynthia D. Mulrow,Peter C Gøtzsche,John P. A. Ioannidis,Mike Clarke,Mike Clarke,Philip J. Devereaux,Jos Kleijnen,David Moher +10 more
TL;DR: An Explanation and Elaboration of the PRISMA Statement is presented and updated guidelines for the reporting of systematic reviews and meta-analyses are presented.
Journal ArticleDOI
Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more
TL;DR: During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.
Journal ArticleDOI
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
Journal ArticleDOI
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration
Alessandro Liberati,Douglas G. Altman,Jennifer Tetzlaff,Cynthia D. Mulrow,Peter C Gøtzsche,John P. A. Ioannidis,Mike Clarke,Philip J. Devereaux,Jos Kleijnen,David Moher +9 more
TL;DR: The meaning and rationale for each checklist item is explained, and an example of good reporting is included and, where possible, references to relevant empirical studies and methodological literature are included.
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