Avian influenza A (H5N1) infection in humans
John H. Beigel,Jeremy Farrar,Aye Maung Han,Frederick G. Hayden,Randy Hyer,Menno D. de Jong,Sorasak Lochindarat,Thi Kim Tien Nguyen,Tran Hien Nguyen,Tinh Hien Tran,Angus Nicoll,Sok Touch,Kwok-Yung Yuen +12 more
Reads0
Chats0
TLDR
The writing committee consisted of the following: John H. Beigel, M.D., National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md, and Jeremy Farrar, D.Phil., Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.Abstract:
The writing committee consisted of the following: John H. Beigel, M.D., National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.; Jeremy Farrar, D.Phil., Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam; Aye Maung Han, M.B., B.S., Department of Child Health, Institute of Medicine, Yangon, Myanmar; Frederick G. Hayden, M.D. (rapporteur), University of Virginia, Charlottesville; Randy Hyer, M.D., World Health Organization, Geneva; Menno D. de Jong, M.D., Ph.D., Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam; Sorasak Lochindarat, M.D., Queen Sirikit National Institute of Child Health, Bangkok, Thailand; Nguyen Thi Kim Tien, M.D., Ph.D., Pasteur Institute, Ho Chi Minh City, Vietnam; Nguyen Tran Hien, M.D., Ph.D., National Institute of Hygiene and Epidemiology, Hanoi; Tran Tinh Hien, M.D., Ph.D., Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam; Angus Nicoll, M.Sc., Health Protection Agency, London; Sok Touch, M.D., Ministry of Health, Phnom Penh, Cambodia; and Kwok-Yung Yuen, M.D., University of Hong Kong, Hong Kong SAR, China. Address reprint requests to Dr. Hayden at the Department of Internal Medicine, P.O. Box 800473, University of Virginia Health Sciences Center, Charlottesville, VA 22908, or at fgh@virginia.edu.read more
Citations
More filters
Journal ArticleDOI
Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults
Lionel A. Mandell,Richard G. Wunderink,Antonio Anzueto,John G. Bartlett,G. Douglas Campbell,Nathan C. Dean,Nathan C. Dean,Scott F. Dowell,Daniel M. Musher,Daniel M. Musher,Michael S. Niederman,Michael S. Niederman,Antoni Torres,Cynthia G. Whitney,Michael E. DeBakey Veterans +14 more
TL;DR: This work presents a meta-analyses of the immune system’s response to chronic obstructive pulmonary disease and shows clear patterns of decline in the immune systems of elderly patients with compromised immune systems.
Journal ArticleDOI
Strategies for mitigating an influenza pandemic
Neil M. Ferguson,Derek A. T. Cummings,Christophe Fraser,James Cajka,Philip C. Cooley,Donald S. Burke +5 more
TL;DR: It is found that border restrictions and/or internal travel restrictions are unlikely to delay spread by more than 2–3 weeks unless more than 99% effective, and vaccine stockpiled in advance of a pandemic could significantly reduce attack rates even if of low efficacy.
Journal ArticleDOI
Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia
Menno D. de Jong,Cameron P. Simmons,Tran Tan Thanh,Vo Minh Hien,Gavin J. D. Smith,Tran Nguyen Bich Chau,Dang Minh Hoang,Nguyen Van Vinh Chau,Truong Huu Khanh,Vo Cong Dong,Phan Tu Qui,Bach Van Cam,Do Quang Ha,Yi Guan,J. S. Malik Peiris,Nguyen Tran Chinh,Tran Tinh Hien,Jeremy Farrar +17 more
TL;DR: The observations indicate that high viral load, and the resulting intense inflammatory responses, are central to influenza H5N1 pathogenesis and the focus of clinical management should be on preventing this intense cytokine response, by early diagnosis and effective antiviral treatment.
Journal ArticleDOI
Emergence and pandemic potential of swine-origin H1N1 influenza virus.
TL;DR: Efforts to control these outbreaks and real-time monitoring of the evolution of this virus should provide invaluable information to direct infectious disease control programmes and to improve understanding of the factors that determine viral pathogenicity and/or transmissibility.
Journal ArticleDOI
Avian flu: influenza virus receptors in the human airway.
TL;DR: An anatomical difference in the distribution in the human airway of the different binding molecules preferred by the avian and human influenza viruses is demonstrated to provide a rational explanation for why H5N1 viruses at present rarely infect and spread between humans although they can replicate efficiently in the lungs.
References
More filters
Journal ArticleDOI
Molecular Basis for High Virulence of Hong Kong H5N1 Influenza A Viruses
TL;DR: Using reverse genetics, it is shown that a mutation at position 627 in the PB2 protein influenced the outcome of infection in mice, and high cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal infection.
Journal ArticleDOI
Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia
K. S. Li,Yi Guan,Yi Guan,Jianbo Wang,Jianbo Wang,Gavin J. D. Smith,Gavin J. D. Smith,K. M. Xu,K. M. Xu,Lian Duan,Lian Duan,A. P. Rahardjo,Pilaipan Puthavathana,Chantanee Buranathai,Toan D. Nguyen,A. T. S. Estoepangestie,A. Chaisingh,Prasert Auewarakul,H. T. Long,N. T. H. Hanh,Richard J. Webby,Leo L.M. Poon,Honglin Chen,Honglin Chen,Kennedy F. Shortridge,Kennedy F. Shortridge,Kwok-Yung Yuen,Robert G. Webster,Robert G. Webster,Joseph S. M. Peiris,Joseph S. M. Peiris +30 more
TL;DR: The findings indicate that domestic ducks in southern China had a central role in the generation and maintenance of this virus, and that wild birds may have contributed to the increasingly wide spread of the virus in Asia.
Journal ArticleDOI
Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome
Ron A. M. Fouchier,Peter M. Schneeberger,Frans W. Rozendaal,Jan M. Broekman,Stiena A. G. Kemink,Vincent J. Munster,Thijs Kuiken,Guus F. Rimmelzwaan,Martin Schutten,Gerard J. J. van Doornum,Guus Koch,A Bosman,Marion Koopmans,Albert D. M. E. Osterhaus +13 more
TL;DR: Because H7N7 viruses have caused disease in mammals, including horses, seals, and humans, on several occasions in the past, they may be unusual in their zoonotic potential and, thus, form a pandemic threat to humans.
Journal ArticleDOI
Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus.
Kwok-Yung Yuen,Paul K.S. Chan,Malik Peiris,D. N. C. Tsang,Tak-Lun Que,Kennedy F. Shortridge,P. T. Cheung,W. K. To,E. T. F. Ho,R. Sung,A. F. B. Cheng +10 more
TL;DR: Avian Influenza A H5N1 virus causes human influenza-like illness with a high rate of complications in adults admitted to hospital, and rapid H5-subtype-specific laboratory diagnosis can be made by RT-PCR applied directly to clinical specimens.
Journal ArticleDOI
The Efficacy of Live Attenuated, Cold-Adapted, Trivalent, Intranasal Influenzavirus Vaccine in Children
Robert B. Belshe,Paul M. Mendelman,John J. Treanor,James C. King,William C. Gruber,Pedro A. Piedra,David I. Bernstein,Frederick G. Hayden,Karen L. Kotloff,Kenneth M. Zangwill,Dominick Iacuzio,Mark Wolff +11 more
TL;DR: A live attenuated, cold-adapted, trivalent influenzavirus vaccine was safe, immunogenic, and effective against influenza A(H3N2) and B in healthy children.