Journal ArticleDOI
Bacterial production of the fungus-derived cholesterol-lowering agent mevinolin.
TLDR
It is found that two of the strains of Salinispora arenicola produced mevinolin, a fungus-derived cholesterol-lowering agent in the Great Barrier Reef region of Australia.Abstract:
Forty-five strains from two different species (Salinispora arenicola and Salinispora pacifica) were isolated from three different marine sponge species in the Great Barrier Reef region of Australia. We found that two of the strains of Salinispora arenicola (MV0335 and MV0029) produced mevinolin, a fungus-derived cholesterol-lowering agent. Compound structure was determined using an integrated approach: (a) high performance liquid chromatography-quadrupole time-of-flight-mass spectrometric analysis with multimode ionization (electrospray ionization and atmospheric pressure chemical ionization) and fast polarity switching; and (b) database searching and matching of monoisotopic masses, retention times and mass spectra of the precursor and product ions of the compounds of interest and the authentic reference standards thereof.read more
Citations
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The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery
TL;DR: An overview of the initial discovery of the marine actinomycete genus Salinispora and its development as a model for natural product research illustrates the extraordinary biosynthetic diversity that can emanate from a narrowly defined genus and supports future efforts to explore marine taxa in the search for novel natural products.
Journal ArticleDOI
Genomic insights into specialized metabolism in the marine actinomycete Salinispora.
Anne-Catrin Letzel,Jing Li,Gregory C. A. Amos,Natalie Millán-Aguiñaga,Joape Ginigini,Usama Ramadan Abdelmohsen,Susana P. Gaudêncio,Nadine Ziemert,Bradley S. Moore,Paul R. Jensen +9 more
TL;DR: The results indicate that recently acquired BGCs can be functional and that complex evolutionary processes shape the micro-diversity of specialized metabolism observed in closely related environmental bacteria.
Journal ArticleDOI
Hypotensive, hypoglycaemic and hypolipidaemic effects of bioactive compounds from microalgae and marine micro-organisms
TL;DR: This study focuses specifically on revealing and discussing prospective human applications of MMs on functional foods and clinical practice and their metabolites associated with hypotensive, hypoglycaemic and hypolipidaemic activities.
Journal ArticleDOI
Diversity and biotechnological potential of microorganisms associated with marine sponges
TL;DR: Recent progress in understanding of this genetic diversity of sponge microorganisms, its retrieval via culture and genomic approaches, and its implications for chemical diversity and other biotechnology applications of spongemicroorganisms and their genes are reviewed.
Journal ArticleDOI
Bioactive natural products from the genus Salinospora: a review
TL;DR: This review arranged Salinispora derived secondary metabolites according to the three species that comprise the genus and described muta- and semi-synthesis analogs derived from salinosporamide.
References
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Journal ArticleDOI
Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.
Alfred W. Alberts,Julie S. Chen,G Kuron,V Hunt,Jesse W. Huff,Carl H. Hoffman,John W. Rothrock,Lopez Maria B,Henry Joshua,Elbert E. Harris,Arthur A. Patchett,R L Monaghan,S Currie,E Stapley,George Albers-Schonberg,Otto D. Hensens,J Hirshfield,Karst Hoogsteen,Jerrold M. Liesch,James P. Springer +19 more
TL;DR: It was shown that mevinolin was an orally active cholesterol-lowering agent in the dog and orally administered sodium mevinolinate was an active inhibitor of cholesterol synthesis in an acute assay.
Journal ArticleDOI
Developing a new resource for drug discovery: marine actinomycete bacteria
William Fenical,Paul R. Jensen +1 more
TL;DR: The continued development of improved cultivation methods and technologies for accessing deep-sea environments promises to provide access to this significant new source of chemical diversity.
Journal ArticleDOI
Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin Biosynthesis
Jonathan Kennedy,Karine Auclair,Steven G. Kendrew,Cheon-Seok Park,John C. Vederas,C. Richard Hutchinson +5 more
TL;DR: Synthesis of the main nonaketide-derived skeleton was found to require the previously known iterative lovastatin nonAKetide synthase (LNKS), plus at least one additional protein that interacts with LNKS and is necessary for the correct processing of the growing polyketide chain and production of dihydromonacolin L.
Journal ArticleDOI
Genomic insights into the marine sponge microbiome
TL;DR: Current understanding of the interactions between marine sponges and their microbial symbiotic consortia is discussed, and recent insights into these relationships from genomic studies are highlighted.
Journal ArticleDOI
Constituents of Red Yeast Rice, a Traditional Chinese Food and Medicine
Jiyuan Ma,Yongguo Li,Qing Ye,Jing Li,Yanjun Hua,Dajun Ju,Decheng Zhang,Raymond Cooper,Michael Chang +8 more
TL;DR: Detailed analyses were undertaken of the natural constituents of red yeast rice, a traditional Chinese medicine and food known for centuries to improve blood circulation, which indicated the presence of a group of metabolites belonging to the monacolin family of polyketides, together with fatty acids, and trace elements.