Beyond leukotriene formation-The noncanonical functions of 5-lipoxygenase
Reads0
Chats0
TLDR
The role of 5-LO in the regulation of stem cell proliferation and differentiation and its biological functions apart from leukotriene and SPM formation are summarized.About:
This article is published in Prostaglandins & Other Lipid Mediators.The article was published on 2019-03-28 and is currently open access. It has received 21 citations till now. The article focuses on the topics: Leukotriene & Cell activation.read more
Citations
More filters
Journal ArticleDOI
African plants with in vitro anti-inflammatory activities: A review
E.E. Elgorashi,Lyndy Joy McGaw +1 more
TL;DR: This review provides an overview of African plants that demonstrated promising anti- inflammatory activity in in vitro studies and highlights the potential of African flora in contributing to anti-inflammatory drug discovery.
Journal ArticleDOI
Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS.
Hojae Lee,Jae Jin Lee,Na Young Park,Sandeep Kumar Dubey,Taeyong Kim,Kai Ruan,Su Bin Lim,Seong-Hyun Park,Shinwon Ha,Irina Kovlyagina,Irina Kovlyagina,Kyung-Tai Kim,Seongjun Kim,Yohan Oh,Yohan Oh,Hyesoo Kim,Sung Ung Kang,Mi-Ryoung Song,Thomas E. Lloyd,Thomas E. Lloyd,Nicholas J. Maragakis,Young Bin Hong,Hyungjin Eoh,Gabsang Lee +23 more
TL;DR: In this paper, a comparative multi-omics analysis of human induced pluripotent stem cell-derived sMNs and ocular motor neurons was applied to identify shared metabolic perturbations in inherited and sporadic ALS sMN, revealing dysregulation in lipid metabolism and its related genes.
Journal ArticleDOI
Inhibition of 5-lipoxygenase is associated with downregulation of the leukotriene B4 receptor 1/ Interleukin-12p35 pathway and ameliorates sepsis-induced myocardial injury.
Saiyang Xie,Xiping Qi,Qing-Qing Wu,Li Wei,Min Zhang,Yun Xing,Wenke Shi,Si Chen,Xiao-Feng Zeng,Sha-Sha Wang,Haipeng Guo,Wei Deng +11 more
TL;DR: In this article, 5-Lox deficiency offered protection against myocardial injury in a mouse model of sepsis and attenuated septic-mediated inflammation, oxidative stress and apoptosis in the mouse heart.
Journal ArticleDOI
Analysis of proximal ALOX5 promoter binding proteins by quantitative proteomics.
TL;DR: It is shown that the ALOX5 promoter can form DNA G‐quadruplex structures, which may play a functional role in ALOX7 gene regulation, and several zinc finger proteins as novel potential ALOx5 gene regulators are identified.
Journal ArticleDOI
Specialized Pro-Resolving Mediators as Potential Regulators of Inflammatory Macrophage Responses in COVID-19.
TL;DR: In this paper, the authors discuss the homeostatic functions of SPMs acting directly on macrophages on various levels, towards the resolution of inflammation and address the molecular events that link the lipid mediators with COVID-19 severity.
References
More filters
Journal ArticleDOI
An integrated encyclopedia of DNA elements in the human genome
TL;DR: The Encyclopedia of DNA Elements project provides new insights into the organization and regulation of the authors' genes and genome, and is an expansive resource of functional annotations for biomedical research.
Journal ArticleDOI
Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration
TL;DR: The Integrative Genomics Viewer (IGV) is a high-performance viewer that efficiently handles large heterogeneous data sets, while providing a smooth and intuitive user experience at all levels of genome resolution.
Journal ArticleDOI
Wnt/beta-catenin signaling in development and disease.
TL;DR: A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades, finding that Germline mutations in the Wnt pathway cause several hereditary diseases, and somatic mutations are associated with cancer of the intestine and a variety of other tissues.
Journal ArticleDOI
Wnt/β-catenin signaling and disease.
Hans Clevers,Roel Nusse +1 more
TL;DR: An update of the core Wnt/β-catenin signaling pathway is provided, how its various components contribute to disease, and outstanding questions to be addressed in the future are discussed.
Journal ArticleDOI
Leukotrienes and lipoxins: structures, biosynthesis, and biological effects
TL;DR: The multiple interaction of lipoxygenases generates compounds that can regulate specific cellular responses of importance in inflammation and immunity.
Related Papers (5)
Calpain as an effector of the Gq signaling pathway for inhibition of Wnt/β-catenin-regulated cell proliferation
Guangnan Li,Ravi Iyengar +1 more