Journal ArticleDOI
Binding studies of truncated variants of the Aβ peptide to the V-domain of the RAGE receptor reveal Aβ residues responsible for binding.
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TLDR
A truncated version of Aβ capable of blocking its receptor-mediated internalization was established, revealing the binding code and providing the lead compound in the process of drug design.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2011-05-01. It has received 33 citations till now. The article focuses on the topics: RAGE (receptor) & Binding domain.read more
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Journal ArticleDOI
The role of advanced glycation end products in various types of neurodegenerative disease: a therapeutic approach
TL;DR: Several new therapeutic approaches that have been applied to treat these devastating disorders, including the use of various synthetic and naturally occurring inhibitors are discussed, including modulation of the AGE-RAGE axis is considered promising in the prevention of neurodegenerative diseases.
Journal ArticleDOI
Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products
Giancarlo Aldini,Giulio Vistoli,Milan Stefek,Niki Chondrogianni,Tilman Grune,Jolanta Sereikaite,Izabela Sadowska-Bartosz,Grzegorz Bartosz +7 more
TL;DR: The review discusses inhibitors of ALE and AGE formation, cross-link breakers, ALE/AGE elimination by enzymes and proteolytic systems, receptors for advanced glycation end products (RAGEs) and blockade of the ligand–RAGE axis.
Book ChapterDOI
RAGE-mediated cell signaling.
TL;DR: RAGE (receptor for advanced glycation end products) is a multi-ligand receptor that belongs to the immunoglobulin superfamily of transmembrane proteins and has been mainly studied as a pathogenetic factor of several diseases.
Journal ArticleDOI
Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia
Yifei Lu,Zhongyuan Guo,Yujie Zhang,Chao Li,Yu Zhang,Qin Guo,Qinjun Chen,Xinli Chen,Xi He,Lisha Liu,Chunhui Ruan,Tao Sun,Bin Ji,Weigen Lu,Chen Jiang +14 more
TL;DR: The results indicate that microglia can be exploited as an early target for AD treatment and their states can be controlled via microenvironment modulation.
Journal ArticleDOI
Is RAGE still a therapeutic target for Alzheimer’s disease?
TL;DR: Despite recent setbacks in the development of RAGE-based therapies for AD, a new generation of compounds that regulate RAGE activity could be efficacious and careful studies are needed to ensure safety and efficacy in chronic treatment before clinical trials.
References
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Journal ArticleDOI
Alzheimer's disease: the amyloid cascade hypothesis
John Hardy,Gerald A. Higgins +1 more
TL;DR: An extensive catalog of genes that act in a migrating cell is provided, unique molecular functions involved in nematode cell migration are identified, and similar functions in humans are suggested.
Journal ArticleDOI
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.
Christian Haass,Dennis J. Selkoe +1 more
TL;DR: Findings in other neurodegenerative diseases indicate that a broadly similar process of neuronal dysfunction is induced by diffusible oligomers of misfolded proteins.
Journal ArticleDOI
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.
Dominic M. Walsh,Igor Klyubin,Julia V. Fadeeva,William K. Cullen,Roger Anwyl,Michael S. Wolfe,Michael J. Rowan,Dennis J. Selkoe +7 more
TL;DR: It is reported that natural oligomers of human Aβ are formed soon after generation of the peptide within specific intracellular vesicles and are subsequently secreted from the cell, indicating that synaptotoxic Aβ oligomers can be targeted therapeutically.
Book
Proteins: Structures and Molecular Properties
TL;DR: This paper discusses the physical properties of polypeptides, the structure of which has been determined Crystallographically to High Resolution and its role in the biosynthesis of Proteins.
Journal ArticleDOI
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.
Ganesh M. Shankar,Shaomin Li,Tapan Mehta,Amaya Garcia-Munoz,Nina E. Shepardson,Imelda M. Smith,Francesca Brett,Michael A. Farrell,Michael J. Rowan,Cynthia A. Lemere,Ciaran M. Regan,Dominic M. Walsh,Bernardo L. Sabatini,Dennis J. Selkoe +13 more
TL;DR: It is concluded that soluble Aβ oligomers extracted from Alzheimer's disease brains potently impair synapse structure and function and that dimers are the smallest synaptotoxic species.
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RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain.
Rashid Deane,Shi Du Yan,Ram Kumar Submamaryan,Barbara LaRue,Suzana Jovanovic,Elizabeth Hogg,Deborah Welch,Lawrence Manness,Chang Lin,Jin Yu,Hong Zhu,Jorge Ghiso,Blas Frangione,Alan Stern,Ann Marie Schmidt,Don L Armstrong,Bernd Arnold,Birgit Liliensiek,Peter P. Nawroth,Florence M. Hofman,Mark S. Kindy,David M. Stern,David M. Stern,Berislav V. Zlokovic +23 more