Journal ArticleDOI
Biodegradation, biodistribution and toxicity of chitosan.
Thomas J. Kean,Maya Thanou +1 more
TLDR
Research in this area is reviewed and chitosan's potential to be used as a generally regarded as safe (GRAS) material is critically discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2010-01-31. It has received 1432 citations till now. The article focuses on the topics: Drug delivery.read more
Citations
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Chitosan—A versatile semi-synthetic polymer in biomedical applications
TL;DR: The chemical structure and relevant biological properties of chitosan for regenerative medicine have been summarized as well as the methods for the preparation of controlled drug release devices and their applications.
Journal ArticleDOI
Recent development of chitosan-based polyelectrolyte complexes with natural polysaccharides for drug delivery.
Yangchao Luo,Qin Wang +1 more
TL;DR: The present review focuses on the recent advances in drug delivery applications of chitosan-based PEC with other natural polysaccharides, including alginate, hyaluronic acid, pectin, carrageenan, xanthan gum, gellan gum, gum arabic, and carboxymethyl cellulose.
Journal ArticleDOI
Recent advances of chitosan nanoparticles as drug carriers.
TL;DR: This paper reviews published research on chitosan nanoparticles, including its preparation methods, characteristics, modification, in vivo metabolic processes, and applications.
Journal ArticleDOI
Does the use of chitosan contribute to oxalate kidney stone formation
Moacir Fernandes Queiroz,Karoline Rachel Teodosio Melo,Diego Araujo Sabry,Guilherme L. Sassaki,Hugo Alexandre Oliveira Rocha +4 more
TL;DR: It is observed that chitosan modifies the morphology and size of these crystals, as well as changes the surface charge of the crystals, making them even more positive, which can facilitate the interaction ofThese crystals with renal cells.
Journal ArticleDOI
Chitosan based hydrogels and their applications for drug delivery in wound dressings: A review
TL;DR: Applications and structural characteristics of different types of active ingredients, such as growth factors, nanoparticles, nanostructures, and drug loaded chitosan hydrogels are summarized.
References
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Journal ArticleDOI
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
Ajay Kumar Gupta,Mona Gupta +1 more
TL;DR: This review discusses the synthetic chemistry, fluid stabilization and surface modification of superparamagnetic iron oxide nanoparticles, as well as their use for above biomedical applications.
Journal ArticleDOI
A review of chitin and chitosan applications
TL;DR: Chitin is the most abundant natural amino polysaccharide and is estimated to be produced annually almost as much as cellulose, and recent progress in chitin chemistry is quite noteworthy as mentioned in this paper.
Journal ArticleDOI
Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles
TL;DR: These factors have been shown to substantially affect the biodistribution and blood circulation half-life of circulating nanoparticles by reducing the level of nonspecific uptake, delaying opsonization, and increasing the extent of tissue specific accumulation.
Journal Article
Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles
TL;DR: In this article, the authors discuss the factors which can influence nanoparticle blood residence time and organ specific accumulation, including interactions with biological barriers and tunable nanoparticle parameters, such as composition, size, core properties, surface modifications (pegylation and surface charge), and targeting ligand functionalization.
Journal ArticleDOI
Chitosan and Its Use as a Pharmaceutical Excipient
TL;DR: The transmucosal absorption promoting characteristics of chitosan has been exploited especially for nasal and oral delivery of polar drugs to include peptides and proteins and for vaccine delivery.