Journal ArticleDOI
Bioengineering approaches to treat the failing heart: from cell biology to 3D printing.
TLDR
A review of state-of-the-art studies, challenges that have not yet been overcome and perspectives on cardiac tissue engineering can be found in this paper, where the most clinically relevant cell sources used in this field and discuss the use of topological, biophysical and metabolic stimuli to obtain mature phenotypes of cardiomyocytes.Abstract:
Successfully engineering a functional, human, myocardial pump would represent a therapeutic alternative for the millions of patients with end-stage heart disease and provide an alternative to animal-based preclinical models. Although the field of cardiac tissue engineering has made tremendous advances, major challenges remain, which, if properly resolved, might allow the clinical implementation of engineered, functional, complex 3D structures in the future. In this Review, we provide an overview of state-of-the-art studies, challenges that have not yet been overcome and perspectives on cardiac tissue engineering. We begin with the most clinically relevant cell sources used in this field and discuss the use of topological, biophysical and metabolic stimuli to obtain mature phenotypes of cardiomyocytes, particularly in relation to organized cytoskeletal and contractile intracellular structures. We then move from the cellular level to engineering planar cardiac patches and discuss the need for proper vascularization and the main strategies for obtaining it. Finally, we provide an overview of several different approaches for the engineering of volumetric organs and organ parts - from whole-heart decellularization and recellularization to advanced 3D printing technologies.read more
Citations
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Review of the Recent Advances in Electrospun Nanofibers Applications in Water Purification
A.A. Nayl,A.I. Abd-Elhamid,Nasser S. Awwad,Mohamed A. Abdelgawad,Jinglei Wu,Xiumei Mo,Sobhi M. Gomha,Ashraf A. Aly,Stefan Bräse +8 more
TL;DR: In this article , a review of recent progress made in the use of electrospun nanofibers to purify polluted water, wherein the distinctive characteristics of this type of nanofiber are essential when using them to remove organic and inorganic pollutants from wastewater, as well as for oil/water (O/W) separation.
Journal ArticleDOI
Development of Innovative Biomaterials and Devices for the Treatment of Cardiovascular Diseases
TL;DR: An overview of the challenges and research frontier of innovative biomaterials and devices for the treatment of cardiovascular diseases and their future development directions are discussed in the conclusion.
Journal ArticleDOI
An Intrapericardial Injectable Hydrogel Patch for Mechanical-Electrical Coupling with Infarcted Myocardium.
Chao-Ming Yu,Zhiwei Yue,Mingyue Shi,Lijie Jiang,Shuang Chen,Mengmeng Yao,Qingyu Yu,Xiaojun Wu,Hong Zhang,Fanglian Yao,Changyong Wang,Hong Sun,Jian Li +12 more
TL;DR: An injectable mechanical-electrical coupling hydrogel patch developed via dynamic covalent/noncovalent cross-linking appropriate for cell encapsulation and minimally invasive implantation into the pericardial cavity that effectively prevents ventricular fibrosis and remodeling, promotes neovascularization, and restores electrical propagation and synchronized pulsation, facilitating the clinical translation of cardiac tissue engineering.
Journal ArticleDOI
Recent Progress and Potential Biomedical Applications of Electrospun Nanofibers in Regeneration of Tissues and Organs
A.A. Nayl,A.I. Abd-Elhamid,Nasser S. Awwad,Mohamed A. Abdelgawad,Jinglei Wu,Xiumei Mo,Sobhi M. Gomha,Ashraf A. Aly,Stefan Bräse +8 more
TL;DR: In this paper , a review of recent progress in electrospun nanofibers and their applications in various biomedical fields, such as bone cell proliferation, nerve regeneration, and vascular tissue, and skin tissue, engineering is presented.
Journal ArticleDOI
Main Applications and Recent Research Progresses of Additive Manufacturing in Dentistry
TL;DR: Wang et al. as mentioned in this paper summarized the main applications and recent research progresses of additive manufacturing in dentistry, and sketched out some challenges and future directions of the additive manufacturing technology for dentistry.
References
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Journal ArticleDOI
Pluripotent stem cell-derived cardiac tissue patch with advanced structure and function.
TL;DR: 3D cell alignment cues in a fibrin-based hydrogel matrix are introduced to engineer highly functional cardiac tissues from genetically purified mouse embryonic stem cell-derived cardiomyocytes and cardiovascular progenitors to provide the foundation for exploiting the exciting progress in pluripotent stem cell research in the future tissue engineering therapies for heart disease.
Journal ArticleDOI
Gold Nanoparticle-Decellularized Matrix Hybrids for Cardiac Tissue Engineering
TL;DR: Gold nanoparticles deposited on fibrous decellularized omental matrices exhibited elongated and aligned morphology, massive striation, and organized connexin 43 electrical coupling proteins, and the hybrid patches demonstrated superior function as compared to pristine patches.
Journal ArticleDOI
Cardiac repair in guinea pigs with human engineered heart tissue from induced pluripotent stem cells.
Florian Weinberger,K. Breckwoldt,Simon Pecha,Allen Kelly,Birgit Geertz,Jutta Starbatty,Timur A. Yorgan,Kai-Hung Cheng,Katrin Lessmann,Tomas Stølen,Marielle Scherrer-Crosbie,Godfrey L. Smith,Godfrey L. Smith,Hermann Reichenspurner,Arne Hansen,Thomas Eschenhagen +15 more
TL;DR: Together, this study demonstrates that three-dimensional human heart muscle constructs can repair the injured heart.
Journal ArticleDOI
Human Embryonic Stem Cell-Derived Cardiomyocytes Regenerate the Infarcted Pig Heart but Induce Ventricular Tachyarrhythmias.
Rocco Romagnuolo,Hassan Masoudpour,Andreu Porta-Sánchez,Beiping Qiang,Jennifer Barry,Andrew R. Laskary,Xiuling Qi,Stéphane Massé,Karl Magtibay,Hiroyuki Kawajiri,Jun Wu,Tamilla Sadikov,Janet Rothberg,Krishna M. Panchalingam,Emily Titus,Ren-Ke Li,Ren-Ke Li,Peter W. Zandstra,Graham A. Wright,Graham A. Wright,Kumaraswamy Nanthakumar,Kumaraswamy Nanthakumar,Nilesh R. Ghugre,Nilesh R. Ghugre,Gordon Keller,Gordon Keller,Michael A. Laflamme,Michael A. Laflamme +27 more
TL;DR: These findings demonstrate the suitability of the pig model for the preclinical development of a hESC-based cardiac therapy and provide new insights into the mechanistic basis of electrical instability following h ESC-CM transplantation.
Journal ArticleDOI
Silk Fibroin Microfluidic Devices
Christopher J. Bettinger,Kathleen M. Cyr,Akira Matsumoto,Robert Langer,Jeffrey T. Borenstein,David L. Kaplan +5 more
TL;DR: Techniques and materials processing strategies utilized in the fabrication of cell-seeded silk fibroin microfluidic devices are described, which have developed material-specific processes for silk Fibroin micromolding and device assembly that is analogous to soft-lithographic techniques.