Journal ArticleDOI
Bioengineering approaches to treat the failing heart: from cell biology to 3D printing.
TLDR
A review of state-of-the-art studies, challenges that have not yet been overcome and perspectives on cardiac tissue engineering can be found in this paper, where the most clinically relevant cell sources used in this field and discuss the use of topological, biophysical and metabolic stimuli to obtain mature phenotypes of cardiomyocytes.Abstract:
Successfully engineering a functional, human, myocardial pump would represent a therapeutic alternative for the millions of patients with end-stage heart disease and provide an alternative to animal-based preclinical models. Although the field of cardiac tissue engineering has made tremendous advances, major challenges remain, which, if properly resolved, might allow the clinical implementation of engineered, functional, complex 3D structures in the future. In this Review, we provide an overview of state-of-the-art studies, challenges that have not yet been overcome and perspectives on cardiac tissue engineering. We begin with the most clinically relevant cell sources used in this field and discuss the use of topological, biophysical and metabolic stimuli to obtain mature phenotypes of cardiomyocytes, particularly in relation to organized cytoskeletal and contractile intracellular structures. We then move from the cellular level to engineering planar cardiac patches and discuss the need for proper vascularization and the main strategies for obtaining it. Finally, we provide an overview of several different approaches for the engineering of volumetric organs and organ parts - from whole-heart decellularization and recellularization to advanced 3D printing technologies.read more
Citations
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Review of the Recent Advances in Electrospun Nanofibers Applications in Water Purification
A.A. Nayl,A.I. Abd-Elhamid,Nasser S. Awwad,Mohamed A. Abdelgawad,Jinglei Wu,Xiumei Mo,Sobhi M. Gomha,Ashraf A. Aly,Stefan Bräse +8 more
TL;DR: In this article , a review of recent progress made in the use of electrospun nanofibers to purify polluted water, wherein the distinctive characteristics of this type of nanofiber are essential when using them to remove organic and inorganic pollutants from wastewater, as well as for oil/water (O/W) separation.
Journal ArticleDOI
Development of Innovative Biomaterials and Devices for the Treatment of Cardiovascular Diseases
TL;DR: An overview of the challenges and research frontier of innovative biomaterials and devices for the treatment of cardiovascular diseases and their future development directions are discussed in the conclusion.
Journal ArticleDOI
An Intrapericardial Injectable Hydrogel Patch for Mechanical-Electrical Coupling with Infarcted Myocardium.
Chao-Ming Yu,Zhiwei Yue,Mingyue Shi,Lijie Jiang,Shuang Chen,Mengmeng Yao,Qingyu Yu,Xiaojun Wu,Hong Zhang,Fanglian Yao,Changyong Wang,Hong Sun,Jian Li +12 more
TL;DR: An injectable mechanical-electrical coupling hydrogel patch developed via dynamic covalent/noncovalent cross-linking appropriate for cell encapsulation and minimally invasive implantation into the pericardial cavity that effectively prevents ventricular fibrosis and remodeling, promotes neovascularization, and restores electrical propagation and synchronized pulsation, facilitating the clinical translation of cardiac tissue engineering.
Journal ArticleDOI
Recent Progress and Potential Biomedical Applications of Electrospun Nanofibers in Regeneration of Tissues and Organs
A.A. Nayl,A.I. Abd-Elhamid,Nasser S. Awwad,Mohamed A. Abdelgawad,Jinglei Wu,Xiumei Mo,Sobhi M. Gomha,Ashraf A. Aly,Stefan Bräse +8 more
TL;DR: In this paper , a review of recent progress in electrospun nanofibers and their applications in various biomedical fields, such as bone cell proliferation, nerve regeneration, and vascular tissue, and skin tissue, engineering is presented.
Journal ArticleDOI
Main Applications and Recent Research Progresses of Additive Manufacturing in Dentistry
TL;DR: Wang et al. as mentioned in this paper summarized the main applications and recent research progresses of additive manufacturing in dentistry, and sketched out some challenges and future directions of the additive manufacturing technology for dentistry.
References
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Myocardial Tissue Engineering with Cells Derived from Human-Induced Pluripotent Stem Cells and a Native-Like, High-Resolution, 3-Dimensionally Printed Scaffold
Ling Gao,Molly E. Kupfer,Jangwook P. Jung,Libang Yang,Patrick Zhang,Yong Da Sie,Quyen A. Tran,Visar Ajeti,Brian T. Freeman,Vladimir G. Fast,Paul J. Campagnola,Brenda M. Ogle,Jianyi Zhang +12 more
TL;DR: The novel multiphoton-excited 3D printing technique produces extracellular matrix–based scaffolds with exceptional resolution and fidelity, and hCMPs fabricated with these scaffolds may significantly improve recovery from ischemic myocardial injury.
Journal ArticleDOI
Evidence for hormonal control of heart regenerative capacity during endothermy acquisition
Kentaro Hirose,Alexander Y. Payumo,Stephen Cutie,Alison Hoang,Hao Zhang,Romain Guyot,Dominic Lunn,Rachel B. Bigley,Hongyao Yu,Jiajia Wang,Megan Smith,Ellen Gillett,Sandra E Muroy,Tobias A. Schmid,Emily Wilson,Kenneth A. Field,DeeAnn M. Reeder,Malcom Maden,Michael M. Yartsev,Michael J. Wolfgang,Frank Grützner,Thomas S. Scanlan,Luke I. Szweda,Rochelle Buffenstein,Guang Hu,Frédéric Flamant,Jeffrey E. Olgin,Guo N. Huang +27 more
TL;DR: It is revealed that diploid cardiomyocyte abundance across 41 species conforms to Kleiber’s law—the ¾-power law scaling of metabolism with bodyweight—and inversely correlates with standard metabolic rate, body temperature, and serum thyroxine level.
Journal ArticleDOI
Human iPS cell-engineered cardiac tissue sheets with cardiomyocytes and vascular cells for cardiac regeneration.
Hidetoshi Masumoto,Takeshi Ikuno,Masafumi Takeda,Hiroyuki Fukushima,Akira Marui,Shiori Katayama,Tatsuya Shimizu,Tadashi Ikeda,Teruo Okano,Ryuzo Sakata,Jun K. Yamashita +10 more
TL;DR: A new protocol for the simultaneous induction of cardiomyocytes and vascular cells is reported, and entirely hiPSC-engineered cardiovascular cell sheets are generated, which showed advantageous therapeutic effects in infarcted hearts.
Journal ArticleDOI
Biodegradable collagen patch with covalently immobilized VEGF for myocardial repair.
TL;DR: It is hypothesized that covalent immobilization of vascular endothelial growth factor to a porous collagen scaffold will enable rapid vascularization in vivo, and angiogenesis in VEGF scaffolds contributed to improved cell survival and tissue formation.
Journal ArticleDOI
Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells.
Elisa Giacomelli,Milena Bellin,Luca Sala,Berend J. van Meer,Leon G.J. Tertoolen,Valeria V. Orlova,Christine L. Mummery,Christine L. Mummery +7 more
TL;DR: Co-differentiation of endothelial cells and cardiomyocytes from human pluripotent stem cells provides a cardiac microtissue model with potential applications for disease modelling and drug discovery.