Journal ArticleDOI
Bioinorganics and biomaterials: bone repair.
TLDR
It is illustrated that inorganics can positively affect bone healing but various factors make literature comparisons difficult and Bioinorganics have the potential to have just as big an impact on bone regeneration as recombinant proteins without some of the safety concerns and high costs.About:
This article is published in Acta Biomaterialia.The article was published on 2011-08-01. It has received 363 citations till now. The article focuses on the topics: Bone growth & Bone regeneration.read more
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Journal ArticleDOI
Bone grafts and biomaterials substitutes for bone defect repair: A review.
Wenhao Wang,Kelvin W.K. Yeung +1 more
TL;DR: The currently available bone grafts and bone substitutes as well as the biological and bio-inorganic factors for the treatments of bone defect are reviewed.
Journal ArticleDOI
Calcium phosphates in biomedical applications: materials for the future?
TL;DR: The aim of this manuscript is to highlight the tremendous improvements achieved in CaP materials research in the past 15 years, in particular in the field of biomineralization, as carrier for gene or ion delivery, as biologically active agent, and as bone graft substitute.
Journal ArticleDOI
Significance of calcium phosphate coatings for the enhancement of new bone osteogenesis – A review ☆
TL;DR: A systematic analysis of results available from in vitro, in vivo and clinical trials on the effects of biocompatible calcium phosphate (CaP) coatings is presented and the future research and use of these devices is discussed.
Journal ArticleDOI
Calcium phosphate cements as drug delivery materials.
TL;DR: An overview of the different approaches taken in the application of calcium phosphate cements for drug delivery in the skeletal system is provided, and the most significant achievements are identified.
Journal ArticleDOI
How smart do biomaterials need to be? A translational science and clinical point of view ☆
Boris Michael Holzapfel,Johannes C. Reichert,Jan-Thorsten Schantz,Uwe Gbureck,Lars Rackwitz,Ulrich Nöth,Franz Jakob,Maximilian Rudert,Jürgen Groll,Dietmar W. Hutmacher +9 more
TL;DR: The purpose of the review is to assess state of the art and future perspectives of the so called "smart biomaterials" from a translational science and specifically clinical point of view and to filter out and discuss which biomedical advances and innovations help to achieve the objective to translate smart biomMaterials from bench to bedside.
References
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Journal ArticleDOI
How useful is SBF in predicting in vivo bone bioactivity
Tadashi Kokubo,Hiroaki Takadama +1 more
TL;DR: Examination of apatite formation on a material in SBF is useful for predicting the in vivo bone bioactivity of a material, and the number of animals used in and the duration of animal experiments can be reduced remarkably by using this method.
Book
Trace Elements in Human and Animal Nutrition
TL;DR: This book discusses the history of zinc, its application in agriculture, and its applications in the management of soil-Plant-Animal relations.
Journal ArticleDOI
LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development
Yaoqin Gong,R. B. Slee,Naomi Fukai,Georges Rawadi,Sergio Roman-Roman,Anthony M. Reginato,H. W. Wang,Tim Cundy,Francis H. Glorieux,Dorit Lev,M. Zacharin,Konrad Oexle,Jose Marcelino,Wafaa M. Suwairi,Shauna Heeger,G. Sabatakos,Suneel S. Apte,W. N. Adkins,J. Allgrove,M. Arslan-Kirchner,J. A. Batch,Peter Beighton,Graeme C.M. Black,R. G. Boles,L. M. Boon,C. Borrone,Han G. Brunner,G. F. Carle,Bruno Dallapiccola,A. De Paepe,B. Floege,M. L. Halfhide,Barbara Hall,Raoul C.M. Hennekam,Tatsuo Hirose,A. Jans,Harald Jüppner,Chong Ae Kim,K. Keppler-Noreuil,A. Kohlschuetter,Didier Lacombe,M. Lambert,E. Lemyre,T. Letteboer,Leena Peltonen,Rajkumar Ramesar,M. Romanengo,H. Somer,E. Steichen-Gersdorf,Beat Steinmann,Beth A. Sullivan,Andrea Superti-Furga,W. Swoboda,M. J. van den Boogaard,W. Van Hul,Miikka Vikkula,Marcela Votruba,Bernhard Zabel,Teresa Garcia,Roland Baron,Bjorn R. Olsen,Matthew L. Warman +61 more
TL;DR: It is reported that LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass accrual during growth and is important for the establishment of peak bone mass.
BookDOI
Principles of bone biology
TL;DR: Basic principles - cell biology biochemistry bone re-modelling and mineral homeostasis the hormones of bone other systemic hormones that influence bone metabolism local regulators of bone molecular mechanisms of metabolic bone diseases pharmacological mechanisms of therapeutics methods in bone research.
Journal ArticleDOI
High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5
Lynn M. Boyden,Junhao Mao,Joseph L. Belsky,Lyle Mitzner,Anita Farhi,Mary Ann Mitnick,Dianqing Wu,Karl L. Insogna,Richard P. Lifton +8 more
TL;DR: The LRP5V171 mutation causes high bone density, with a thickened mandible and torus palatinus, by impairing the action of a normal antagonist of the Wnt pathway and thus increasing Wnt signaling.