Journal ArticleDOI
Biomimetic approaches for targeting tumor inflammation.
Alessandro Parodi,Dmitry Kostyushev,Sergey Brezgin,Anastasiya Kostyusheva,Tatiana Borodina,Roman Akasov,Anastasia Frolova,Vladimir Chulanov,Andrey A. Zamyatnin +8 more
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TLDR
A review of recent developments in biomimetic drug delivery with a particular focus on targeting the tumor inflammatory microenvironment can be found in this article , where a new field of nanomedicine called biomimicry has evolved to generate nanoparticles with the same biological characteristics as cells that naturally infiltrate tumors.About:
This article is published in Seminars in Cancer Biology.The article was published on 2022-04-23. It has received 12 citations till now. The article focuses on the topics: Medicine & Nanocarriers.read more
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Journal ArticleDOI
The promising interplay between sonodynamic therapy and nanomedicine
TL;DR: In this paper , the main mechanisms involved in non-thermal ultrasound (US) are discussed with particular attention to the sonosensitizers involved for each described mechanism, in order to highlight how much important are the physicochemical properties of the sonoSitizers and their cellular localization to predict their bioeffects.
Journal ArticleDOI
Prognostic value of neutrophil-to-lymphocyte ratio in colorectal cancer liver metastasis: A meta-analysis of results from multivariate analysis.
TL;DR: In this paper , a comprehensive search was conducted across PubMed, MedLine, and the Cochrane Library databases for articles published from January 1, 2000 to April 30, 2022 that investigated the long-term prognostic value of neutrophil-to-lymphocyte ratio (NLR) in colorectal cancer liver metastasis (CRLM).
Journal ArticleDOI
Anticancer Nanotherapeutics in Clinical Trials: The Work behind Clinical Translation of Nanomedicine
Alessandro Parodi,E. P. Kolesova,M. V. Voronina,Anastasia S. Frolova,Dmitry Kostyushev,Daria B. Trushina,Roman Akasov,Tatiana N. Pallaeva,Andrey A. Zamyatnin +8 more
TL;DR: In this article , the authors considered different platforms that reached the clinical trial investigation, providing an objective analysis about their physical and chemical properties and the working mechanism at the basis of their tumoritr opic properties.
Journal ArticleDOI
Innovative nanotheranostics: Smart nanoparticles based approach to overcome breast cancer stem cells mediated chemo- and radioresistances.
Prithwish Kola,Prasanth Kumar Bhusetty Nagesh,P. Roy,Kumar Deepak,Rui L. Reis,Subhas C. Kundu,Mahitosh Mandal +6 more
TL;DR: In this article , the authors discuss several novel theranostic systems and smart nanoparticles, their mechanism of action, and their modifications with time, and explain their relevance and market scope in the current era.
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Physiologically Based Pharmacokinetic Modeling of Nanoparticle Biodistribution: A Review of Existing Models, Simulation Software, and Data Analysis Tools
Elena Kutumova,Ilya R. Akberdin,Ilya Kiselev,Ruslan N. Sharipov,Vera S. Egorova,Anastasiia O. Syrocheva,Alessandro Parodi,Andrey A. Zamyatnin,Fedor A. Kolpakov +8 more
TL;DR: The goal of this review was to highlight the advantages that computational modeling could provide to nanomedicine and bring together scientists with different background by portraying in the most simple way the work of computational developers through the description of the tools that they use to predict nanoparticle transport and tumor targeting in the authors' body.
References
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Journal ArticleDOI
Cancer-related inflammation.
TL;DR: The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
TL;DR: The basic characteristics of the EPR effect, particularly the factors involved, are described, as well as its modulation for improving delivery of macromolecular drugs to the tumor.
Journal ArticleDOI
Analysis of nanoparticle delivery to tumours
Stefan Wilhelm,Anthony J. Tavares,Qin Dai,Seiichi Ohta,Seiichi Ohta,Julie Audet,Harold F. Dvorak,Warren C. W. Chan +7 more
TL;DR: This Perspective explores and explains the fundamental dogma of nanoparticle delivery to tumours and answers two central questions: ‘ how many nanoparticles accumulate in a tumour?’ and ‘how does this number affect the clinical translation of nanomedicines?'
Journal ArticleDOI
Integrins in cancer: biological implications and therapeutic opportunities
TL;DR: Clinical developments emphasize the need to identify how integrin antagonists influence the tumour and its microenvironment.
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