Journal ArticleDOI
Bridging lectin binding sites by multivalent carbohydrates.
TLDR
This article summarizes recent examples of chelating lectin ligands of different size and suggests that chelates binding of the discussed ligands is likely, but experimental proof, for example by X-ray crystallography, is limited to only a few cases.Abstract:
Carbohydrate–protein interactions are involved in a multitude of biological recognition processes Since individual protein–carbohydrate interactions are usually weak, multivalency is often required to achieve biologically relevant binding affinities and selectivities Among the possible mechanisms responsible for binding enhancement by multivalency, the simultaneous attachment of a multivalent ligand to several binding sites of a multivalent receptor (ie chelation) has been proven to have a strong impact This article summarizes recent examples of chelating lectin ligands of different size Covered lectins include the Shiga-like toxin, where the shortest distance between binding sites is ca 9 A, wheat germ agglutinin (WGA) (shortest distance between binding sites 13–14 A), LecA from Pseudomonas aeruginosa (shortest distance 26 A), cholera toxin and heat-labile enterotoxin (shortest distance 31 A), anti-HIV antibody 2G12 (shortest distance 31 A), concanavalin A (ConA) (shortest distance 72 A), RCA120 (shortest distance 100 A), and Erythrina cristagalli (ECL) (shortest distance 100 A) While chelating binding of the discussed ligands is likely, experimental proof, for example by X-ray crystallography, is limited to only a few casesread more
Citations
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疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
Glycomimetics versus multivalent glycoconjugates for the design of high affinity lectin ligands.
Journal ArticleDOI
Emerging concepts in the nutraceutical and functional properties of pectin—A Review
TL;DR: Insights into the advances in the production of pectin, the role it plays as a nutraceutical, possible prebiotic potential and a delivery vehicle for probiotics, and food applications are highlighted.
Journal ArticleDOI
Organizing multivalency in carbohydrate recognition
TL;DR: This review is focused on smaller multivalent structures such as glycoclusters emphasizing carbohydrate-centered and heteromultivalent glycoconjugates and approaches to organize multivalency.
Journal ArticleDOI
Pectin in cancer therapy: A review
Wenbo Zhang,Ping Xu,Han Zhang +2 more
TL;DR: Pectin is a suitable vehicle for anti-cancer drug delivery systems, due to its abundant modifiable functional groups and special physicochemical properties and the structure-activity relationship of MPs.
References
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疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors.
TL;DR: Polyvalent interactions can be collectively much stronger than corresponding monovalent interactions, and they can provide the basis for mechanisms of both agonizing and antagonizing biological interactions that are fundamentally different from those available inmonovalent systems.
Journal ArticleDOI
Nanoparticle PEGylation for imaging and therapy
TL;DR: A background to investigators new to stealth nanoparticles is presented, and some key considerations needed prior to designing a nanoparticle PEGylation protocol and characterizing the performance features of the product are suggested.
Journal ArticleDOI
Carbohydrate-Protein Interactions: Basis of Glycobiology
Yuan C. Lee,R. T. Lee +1 more
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