Journal ArticleDOI
Bridging the regeneration gap: genetic insights from diverse animal models
TLDR
This work has begun to delineate differences and similarities in the regenerative capabilities and mechanisms among diverse animal species, and to address some of the key questions about the molecular and cell biology of regeneration.Abstract:
Significant progress has recently been made in our understanding of animal regenerative biology, spurred on by the use of a wider range of model organisms and an increasing ability to use genetic tools in traditional models of regeneration. This progress has begun to delineate differences and similarities in the regenerative capabilities and mechanisms among diverse animal species, and to address some of the key questions about the molecular and cell biology of regeneration. Our expanding knowledge in these areas not only provides insights into animal biology in general, but also has important implications for regenerative medicine and stem-cell biology.read more
Citations
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Comparative Aspects of Animal Regeneration
Jeremy P. Brockes,Anoop Kumar +1 more
TL;DR: The evolutionary origins of regeneration and how regeneration may relate to both agametic reproduction and to ontogeny are considered, including examples of species that are able to regenerate large sections of the body plan.
Journal ArticleDOI
β-Catenin Defines Head Versus Tail Identity During Planarian Regeneration and Homeostasis
TL;DR: It is suggested that β-catenin functions as a molecular switch to specify and maintain anteroposterior identity during regeneration and homeostasis in planarians.
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Evolution of animal regeneration: re-emergence of a field
TL;DR: The phylogenetic distribution of regeneration is reviewed and how the origin, maintenance and loss of regeneration can each be driven by distinct factors are discussed.
Journal ArticleDOI
Apoptotic cells provide an unexpected source of Wnt3 signaling to drive hydra head regeneration.
Simona Chera,Luiza Ghila,Kevin Dobretz,Yvan Wenger,Christoph Ruediger Bauer,Wanda Christa Buzgariu,Jean-Claude Martinou,Brigitte Galliot +7 more
TL;DR: It is proposed that different types of injuries induce distinct cellular modes of Hydra head regeneration, which nonetheless converge on a central effector, Wnt3, which is reminiscent of proliferative blastemas in regenerating limbs and of compensatory proliferation induced by dying cells in Drosophila imaginal discs.
Journal ArticleDOI
Slicing across Kingdoms: Regeneration in Plants and Animals
TL;DR: The question remains in both plants and animals whether regeneration invokes embryogenesis, generic patterning mechanisms, or unique circuitry comprised of well-established patterning genes.
References
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Journal ArticleDOI
Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts
Charles E. Murry,Mark H. Soonpaa,Hans Reinecke,Hidehiro Nakajima,Hisako O. Nakajima,Michael Rubart,Kishore B.S. Pasumarthi,Kishore B.S. Pasumarthi,Jitka A. I. Virag,Stephen H. Bartelmez,Veronica Poppa,Gillian Bradford,Joshua D. Dowell,David A. Williams,David A. Williams,Loren J. Field +15 more
TL;DR: Results indicate that haematopoietic stem cells do not readily acquire a cardiac phenotype, and raise a cautionary note for clinical studies of infarct repair.
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Heart Regeneration in Zebrafish
TL;DR: It is demonstrated histologically that zebrafish fully regenerate hearts within 2 months of 20% ventricular resection, showing that injury-induced cardiomyocyte proliferation in zebra fish can overcome scar formation, allowing cardiac muscle regeneration.
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Tunicates and not cephalochordates are the closest living relatives of vertebrates
TL;DR: It is shown that phylogenetic analyses of the genome sequencing of the appendicularian Oikopleura dioica provide compelling evidence that tunicates, and not cephalochordates, represent the closest living relatives of vertebrates.
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A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal.
TL;DR: The Drosophila piwi gene is cloned and characterized and it is shown that it is required for the asymmetric division of GSCs to produce and maintain a daughter GSC but is not essential for the further differentiation of the committed daughter cell.
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Fundamentals of planarian regeneration
TL;DR: The types of structures produced by blastemas on a variety of wound surfaces, the principles guiding the reorganization of pre-existing tissues, and the manner in which scale and cell number proportions between body regions are restored during regeneration are identified.