Journal ArticleDOI
Brønsted acid activation strategy in transition-metal catalyzed asymmetric hydrogenation of N-unprotected imines, enamines, and N-heteroaromatic compounds.
TLDR
The recent advances in transition-metal-catalyzed, Brønsted acid activated asymmetric hydrogenation of these challenging substrates, thus offering a promising substrate activation strategy for transformations involving C=N bonds.Abstract:
Asymmetric hydrogenation plays an important role in organic synthesis, but that of the challenging substrates such as N-unprotected imines, enamines, and N-heteroaromatic compounds (1H-indoles, 1H-pyrroles, pyridines, quinolines, and quinoxalines) has only received increased attention in the past three years. Considering the interaction modes of a Bronsted acid with a Lewis base, Bronsted acids may be used as the ideal activators of C=N bonds. This Minireview summarizes the recent advances in transition-metal-catalyzed, Bronsted acid activated asymmetric hydrogenation of these challenging substrates, thus offering a promising substrate activation strategy for transformations involving C=N bonds.read more
Citations
More filters
Journal ArticleDOI
Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates
Journal ArticleDOI
Asymmetric ion-pairing catalysis.
Katrien Brak,Eric N. Jacobsen +1 more
TL;DR: This review describes developments in the burgeoning field of asymmetric ion-pairing catalysis with an emphasis on the insights that have been gleaned into the structural and mechanistic features that contribute to high asymmetric induction.
Journal ArticleDOI
Asymmetric Counteranion-Directed Catalysis: Concept, Definition, and Applications
Manuel Mahlau,Benjamin List +1 more
TL;DR: This Review closes this gap by providing a clear definition of ACDC and by examining both clear cases as well as more ambiguous examples to illustrate the differences and overlaps with other catalysis concepts.
Journal ArticleDOI
Supramolecular catalysis. Part 1: non-covalent interactions as a tool for building and modifying homogeneous catalysts.
TL;DR: In this review, special attention will be given to supramolecular catalysts for which the observed catalytic activity and/or selectivity have been imputed to non-covalent interaction between the reaction partners.
Journal ArticleDOI
Key Green Chemistry research areas from a pharmaceutical manufacturers’ perspective revisited
Marian C. Bryan,Peter J. Dunn,David Entwistle,Fabrice Gallou,Stefan G. Koenig,John D. Hayler,Matthew R. Hickey,Shaun Hughes,Michael E. Kopach,Gerard Moine,Paul G. Richardson,Frank Roschangar,Alan Steven,Franz J. Weiberth +13 more
TL;DR: In 2007, the members of the ACS Green Chemistry Institute® Pharmaceutical Roundtable assembled a list of key green chemistry research areas to both identify transformations that would benefit from improvements in process greenness and to encourage academic research to this end as mentioned in this paper.
References
More filters
Journal ArticleDOI
Small-molecule H-bond donors in asymmetric catalysis.
Journal ArticleDOI
New Chiral Phosphorus Ligands for Enantioselective Hydrogenation
Wenjun Tang,Xumu Zhang +1 more
TL;DR: The increasing demand to produce enantiomerically pure pharmaceuticals, agrochemicals, flavors, and other fine chemicals has advanced the field of asymmetric catalytic technologies, and asymmetric hydrogenation utilizing molecular hydrogen to reduce prochiral olefins, ketones, and imines has become one of the most efficient methods for constructing chiral compounds.
Journal ArticleDOI
Organocatalysis--after the gold rush.
TL;DR: This tutorial review will firstly sketch the basic developments in organocatalysis, focussing especially on the use of secondary amines as catalysts for the functionalization of aldehydes and alpha,beta-unsaturated aldeHydes, with emphasis on the mechanisms of the transformations and outline recent trends within central areas of this research topic.
Journal ArticleDOI
Chiral Phosphoric Acids asVersatile Catalysts for Enantioselective Transformations
TL;DR: In this paper, a review focusing on recent achievements in the development of enantioselective transforma- tions using these axially chiral phosphoric acids and their analogues as chiral Bronsted acid catalysts is presented.