Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain
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TLDR
It is suggested that CR is neuroprotective; ketone bodies, cerebral blood flow, and α-ketoglutarate may play important roles in preserving brain physiology in aging.About:
This article is published in Neurobiology of Aging.The article was published on 2015-07-01 and is currently open access. It has received 61 citations till now. The article focuses on the topics: Ketone bodies & Aging brain.read more
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Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans.
Slaven Stekovic,Sebastian J. Hofer,Norbert J. Tripolt,Miguel A. Aon,Philipp Royer,Lukas Pein,Julia T. Stadler,Julia T. Stadler,Tobias Pendl,Barbara Prietl,Jasmin Url,Sabrina Schroeder,Jelena Tadic,Tobias Eisenberg,Christoph Magnes,Michael Stumpe,Elmar Zuegner,Natalie Bordag,Regina Riedl,Albrecht Schmidt,Ewald Kolesnik,Nicolas Verheyen,Anna Springer,Tobias Madl,Frank Sinner,Frank Sinner,Rafael de Cabo,Guido Kroemer,Barbara Obermayer-Pietsch,Jörn Dengjel,Jörn Dengjel,Harald Sourij,Thomas R. Pieber,Thomas R. Pieber,Frank Madeo +34 more
TL;DR: It is shown that 4 weeks of strict alternate day fasting (ADF) improved markers of general health in healthy, middle-aged humans while causing a 37% calorie reduction on average, and supports its safety.
Journal ArticleDOI
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.
Yasir S Elhassan,Yasir S Elhassan,Katarina Kluckova,Rachel Fletcher,Mark S. Schmidt,Antje Garten,Craig L. Doig,David Cartwright,Lucy Oakey,Claire V. Burley,Ned Jenkinson,Martin Wilson,Samuel J. E. Lucas,Ildem Akerman,Alex P. Seabright,Yu-Chiang Lai,Daniel A. Tennant,Peter Nightingale,Gareth A. Wallis,Konstantinos N. Manolopoulos,Konstantinos N. Manolopoulos,Charles Brenner,Andrew Philp,Andrew Philp,Andrew Philp,Gareth G. Lavery,Gareth G. Lavery +26 more
TL;DR: The data establish that oral NR is available to aged human muscle and identify anti-inflammatory effects of NR, and reveal NR-mediated downregulation of energy metabolism and mitochondria pathways, without altering mitochondrial bioenergetics.
Journal ArticleDOI
Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect.
TL;DR: The reciprocal regulation of cancer cell's metabolic alterations and the microenvironment, involving extensive host immune cells and microbiota, have come into view as critical mechanisms to regulate cancer progression and are shaping the current and future paradigm of cancer metabolism.
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Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice
David Ma,Amy C Wang,Ishita Parikh,Stefan J. Green,Jared D. Hoffman,George E. Chlipala,M. Paul Murphy,Brent S. Sokola,Björn Bauer,Anika M.S. Hartz,Ai-Ling Lin +10 more
TL;DR: The findings suggest that ketogenic diet intervention started in the early stage may enhance brain vascular function, increase beneficial gut microbiota, improve metabolic profile, and reduce risk for AD.
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Feasibility and efficacy data from a ketogenic diet intervention in Alzheimer's disease.
TL;DR: The feasibility and cognitive effects of a ketogenic diet in participants with Alzheimer's disease are assessed and the benefits and risks of the diet are compared.
References
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A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine
TL;DR: The mitochondria provide a direct link between the authors' environment and their genes and the mtDNA variants that permitted their forbears to energetically adapt to their ancestral homes are influencing their health today.
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Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization
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Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Ricki J. Colman,Rozalyn M. Anderson,Sterling C. Johnson,Erik K. Kastman,Kristopher J. Kosmatka,T. Mark Beasley,David B. Allison,Christina Cruzen,Heather A. Simmons,Joseph W. Kemnitz,Richard Weindruch +10 more
TL;DR: Findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research demonstrate that CR slows aging in a primate species.
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Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects.
Peter T. Fox,Marcus E. Raichle +1 more
TL;DR: Dynamic, physiological regulation of CBF by a mechanism (neuronal or biochemical) dependent on neuronal firing per se, but independent of the cerebral metabolic rate of oxygen, is hypothesized.
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Nonoxidative glucose consumption during focal physiologic neural activity
TL;DR: Transient increases in neural activity cause a tissue uptake of glucose in excess of that consumed by oxidative metabolism, acutely consume much less energy than previously believed, and regulate local blood flow for purposes other than oxidative metabolism.