J
Jeffrey M. Burns
Researcher at University of Kansas
Publications - 240
Citations - 10414
Jeffrey M. Burns is an academic researcher from University of Kansas. The author has contributed to research in topics: Dementia & Medicine. The author has an hindex of 45, co-authored 202 publications receiving 8108 citations. Previous affiliations of Jeffrey M. Burns include University of Virginia & Tufts Medical Center.
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Journal ArticleDOI
Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis
Yasser Iturria-Medina,Roberto C. Sotero,Paule-Joanne Toussaint,José María Mateos-Pérez,Alan C. Evans,Michael W. Weiner,Paul S. Aisen,Ronald C. Petersen,Clifford R. Jack,William J. Jagust,John Q. Trojanowki,Arthur W. Toga,Laurel A. Beckett,Robert C. Green,Andrew J. Saykin,John C. Morris,Leslie M. Shaw,Zaven S. Khachaturian,Greg Sorensen,Lew Kuller,Marc Raichle,Steven M. Paul,Peter Davies,Howard Fillit,Franz Hefti,Davie Holtzman,M. Marcel Mesulam,William Z. Potter,Peter J. Snyder,Adam Schwartz,T. J. Montine,Ronald G. Thomas,Michael C. Donohue,Sarah Walter,Devon Gessert,Tamie Sather,Gus Jiminez,Danielle J Harvey,Matt A. Bernstein,Nick C. Fox,Paul M. Thompson,Norbert Schuff,Bret J. Borowski,Jeff Gunter,M. L. Senjem,Prashanthi Vemuri,David T.W. Jones,Kejal Kantarci,Chad Ward,Robert A. Koeppe,Norm Foster,Eric M. Reiman,Kewei Chen,Chet Mathis,Susan M. Landau,Nigel J. Cairns,Erin Householder,Lisa Taylor-Reinwald,Virginia M.-Y. Lee,Magdalena Korecka,Michal J. Figurski,Karen Crawford,Scott C. Neu,Tatiana Foroud,Steven G. Potkin,Li Shen,Kelley Faber,Sungeun Kim,Kwangsik Nho,Leon J. Thal,Neil Buckholtz,M.S. Albert,Richard Frank,John K. Hsiao,Jeffrey Kaye,Joseph F. Quinn,Betty Lind,Raina Carter,Sara Dolen,Lon S. Schneider,Sonia Pawluczyk,Mauricio Beccera,Liberty Teodoro,Bryan M. Spann,James B. Brewer,Helen Vanderswag,Adam S. Fleisher,Judith L. Heidebrink,Joanne L. Lord,Sara S. Mason,Colleen S. Albers,David S. Knopman,Kris Johnson,Rachelle S. Doody,Javier Villanueva-Meyer,Munir Chowdhury,Susan Rountree,Mimi Dang,Yaakov Stern,Lawrence S. Honig,Karen L. Bell,Beau M. Ances,Maria Carroll,Sue Leon,Mark A. Mintun,Stacy Schneider,Angela Oliver,Daniel C. Marson,Randall Griffith,David Glenn Clark,David S. Geldmacher,John C. Brockington,Erik D. Roberson,Hillel Grossman,Effie M. Mitsis,Leyla de Toledo-Morrell,Raj C. Shah,Ranjan Duara,Daniel Varon,Maria T. Greig,Peggy Roberts,Marilyn S. Albert,Chiadi U. Onyike,Daniel D'Agostino,Stephanie Kielb,James E. Galvin,Brittany Cerbone,Christina A. Michel,Henry Rusinek,Mony J. de Leon,Lidia Glodzik,Susan De Santi,P. Murali Doraiswamy,Jeffrey R. Petrella,Terence Z. Wong,Steven E. Arnold,Jason Karlawish,David A. Wolk,Charles D. Smith,Greg Jicha,Peter A. Hardy,Partha Sinha,Elizabeth Oates,Gary R. Conrad,Oscar L. Lopez,MaryAnn Oakley,Donna M. Simpson,Anton P. Porsteinsson,Bonnie S. Goldstein,Kim Martin,Kelly M. Makino,M. Saleem Ismail,Connie Brand,Ruth A. Mulnard,Gaby Thai,Catherine Mc-Adams-Ortiz,Kyle B. Womack,Dana Mathews,Mary Quiceno,Ramon Diaz-Arrastia,Richard V. King,Myron F. Weiner,Kristen Martin-Cook,Michael D. Devous,Allan I. Levey,James J. Lah,Janet S. Cellar,Jeffrey M. Burns,Heather Anderson,Russell H. Swerdlow,Liana G. Apostolova,Kathleen Tingus,Ellen Woo,Daniel H.S. Silverman,Po H. Lu,George Bartzokis,Neill R. Graff-Radford,Francine Parfitt,Tracy Kendall,Heather Johnson,Martin R. Farlow,Annmarie Hake,Brandy R. Matthews,Scott Herring,Cynthia Hunt,Christopher H. van Dyck,Richard E. Carson,Martha G. MacAvoy,Howard Chertkow,Howard Bergman,Chris Hosein,Sandra E. Black,Bojana Stefanovic,Curtis Caldwell,Ging-Yuek Robin Hsiung,Howard Feldman,Benita Mudge,Michele Assaly,Andrew Kertesz,John Rogers,Charles Bernick,Donna Munic,Diana R. Kerwin,M.-Marsel Mesulam,Kristine Lipowski,Chuang Kuo Wu,Nancy Johnson,Carl H. Sadowsky,Walter Martinez,Teresa Villena,Raymond Scott Turner,Kathleen Johnson,Brigid Reynolds,Reisa A. Sperling,Keith A. Johnson,Gad A. Marshall,Meghan Frey,Barton Lane,Allyson Rosen,Jared R. Tinklenberg,Marwan N. Sabbagh,Christine M. Belden,Sandra Jacobson,Sherye A. Sirrel,Neil W. Kowall,Ronald J. Killiany,Andrew E. Budson,Alexander Norbash,Patricia Lynn Johnson,Joanne S. Allard,Alan J. Lerner,Paula Ogrocki,Leon Hudson,Evan Fletcher,Owen Carmichael,John M Olichney,Charles DeCarli,Smita Kittur,Michael Borrie,T. Y. Lee,Rob Bartha,Sterling C. Johnson,Sanjay Asthana,Cynthia M. Carlsson,Steven Potkin,Adrian Preda,Dana Nguyen,Pierre N. Tariot,Stephanie Reeder,Vernice Bates,Horacio Capote,Michelle Rainka,Douglas W. Scharre,Maria Kataki,Anahita Adeli,Earl A. Zimmerman,Dzintra Celmins,Alice D. Brown,Godfrey D. Pearlson,Karen Blank,Karen E. Anderson,Robert B. Santulli,Tamar J. Kitzmiller,Eben S. Schwartz,Kaycee M. Sink,Jeff D. Williamson,Pradeep Garg,Franklin Watkins,Brian R. Ott,Henry W. Querfurth,Geoffrey Tremont,Stephen Salloway,Paul Malloy,Stephen Correia,Howard J. Rosen,Bruce L. Miller,Jacobo Mintzer,Kenneth M. Spicer,David Bachman,Elizabether Finger,Stephen H. Pasternak,Irina Rachinsky,Dick J. Drost,Nunzio Pomara,Raymundo Hernando,Antero Sarrael,Susan K. Schultz,Laura L. Boles Ponto,Hyungsub Shim,Karen Elizabeth Smith,Norman R. Relkin,Gloria Chaing,Lisa Raudin,Amanda Smith,Kristin Fargher,Balebail Ashok Raj,Thomas C. Neylan,Jordan Grafman,Melissa Davis,Rosemary H Morrison,Jacqueline Hayes,Shannon Finley,Karl E. Friedl,Debra A. Fleischman,Konstantinos Arfanakis,Olga James,Dino Massoglia,J. Jay Fruehling,Sandra Harding,Elaine R. Peskind,Eric C. Petrie,Gail Li,Jerome A. Yesavage,Joy L. Taylor,Ansgar J. Furst +314 more
TL;DR: Imaging results suggest that intra-brain vascular dysregulation is an early pathological event during disease development, suggesting early memory deficit associated with the primary disease factors.
Journal ArticleDOI
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Rebecca Sims,Sven J. van der Lee,Adam C. Naj,Céline Bellenguez,Céline Bellenguez,Nandini Badarinarayan,Johanna Jakobsdottir,Brian W. Kunkle,Anne Boland,Rachel Raybould,Joshua C. Bis,Eden R. Martin,Benjamin Grenier-Boley,Benjamin Grenier-Boley,Stefanie Heilmann-Heimbach,Vincent Chouraki,Vincent Chouraki,Amanda B. Kuzma,Kristel Sleegers,Kristel Sleegers,Maria Vronskaya,Agustín Ruiz,Robert R. Graham,Robert Olaso,Per Hoffmann,Per Hoffmann,Megan L. Grove,Badri N. Vardarajan,Mikko Hiltunen,Markus M. Nöthen,Charles C. White,Kara L. Hamilton-Nelson,Jacques Epelbaum,Wolfgang Maier,Wolfgang Maier,Seung Hoan Choi,Gary W. Beecham,Cécile Dulary,Stefan Herms,Stefan Herms,Albert V. Smith,Cory C. Funk,Céline Derbois,Andreas J. Forstner,Shahzad Ahmad,Hong-Dong Li,Delphine Bacq,Denise Harold,Claudia L. Satizabal,Claudia L. Satizabal,Otto Valladares,Alessio Squassina,Rhodri Thomas,Jennifer A. Brody,Liming Qu,Pascual Sánchez-Juan,Taniesha Morgan,Frank J. Wolters,Yi Zhao,Florentino Sanchez Garcia,Nicola Denning,Myriam Fornage,John Malamon,Maria Candida Deniz Naranjo,Elisa Majounie,Thomas H. Mosley,Beth A. Dombroski,David Wallon,Michelle K. Lupton,Michelle K. Lupton,Josée Dupuis,Patrice L. Whitehead,Laura Fratiglioni,Laura Fratiglioni,Christopher Medway,Xueqiu Jian,Shubhabrata Mukherjee,Lina Keller,Kristelle Brown,Honghuang Lin,Laura B. Cantwell,Francesco Panza,Bernadette McGuinness,Sonia Moreno-Grau,Jeremy D. Burgess,Vincenzo Solfrizzi,Petra Proitsi,Hieab H.H. Adams,Mariet Allen,Davide Seripa,Pau Pastor,L. Adrienne Cupples,L. Adrienne Cupples,Nathan D. Price,Didier Hannequin,Ana Frank-García,Ana Frank-García,Daniel Levy,Daniel Levy,Paramita Chakrabarty,Paolo Caffarra,Paolo Caffarra,Ina Giegling,Alexa S. Beiser,Alexa S. Beiser,Vilmantas Giedraitis,Harald Hampel,Harald Hampel,Melissa E. Garcia,Xue Wang,Lars Lannfelt,Patrizia Mecocci,Gudny Eiriksdottir,Paul K. Crane,Florence Pasquier,Florence Pasquier,Virginia Boccardi,Isabel Henández,Robert Barber,Martin Scherer,Lluís Tárraga,Perrie M. Adams,Markus Leber,Yuning Chen,Marilyn S. Albert,Steffi G. Riedel-Heller,Valur Emilsson,Duane Beekly,Anne Braae,Reinhold Schmidt,Deborah Blacker,Carlo Masullo,Helena Schmidt,Rachelle S. Doody,Gianfranco Spalletta,W. T. Longstreth,Thomas Fairchild,Paola Bossù,Oscar L. Lopez,Matthew P. Frosch,Eleonora Sacchinelli,Bernardino Ghetti,Qiong Yang,Ryan M. Huebinger,Frank Jessen,Frank Jessen,Frank Jessen,Shuo Li,M. Ilyas Kamboh,John C. Morris,Oscar Sotolongo-Grau,Mindy J. Katz,Chris Corcoran,Melanie L. Dunstan,Amy Braddel,Charlene Thomas,Alun Meggy,Rachel Marshall,Amy Gerrish,Jade Chapman,Miquel Aguilar,Sarah Taylor,Matt Hill,Monica Diez Fairen,Angela Hodges,Bruno Vellas,Hilkka Soininen,Iwona Kłoszewska,Makrina Daniilidou,James Uphill,Yogen Patel,Joseph T. Hughes,Jenny Lord,James Turton,Annette M. Hartmann,Roberta Cecchetti,Chiara Fenoglio,Maria Serpente,Marina Arcaro,Carlo Caltagirone,Maria Donata Orfei,Antonio Ciaramella,Sabrina Pichler,Manuel Mayhaus,Wei Gu,Alberto Lleó,Juan Fortea,Rafael Blesa,Imelda Barber,Keeley J. Brookes,Chiara Cupidi,Raffaele Maletta,David Carrell,Sandro Sorbi,Susanne Moebus,Maria Urbano,Alberto Pilotto,Johannes Kornhuber,Paolo Bosco,Stephen Todd,David Craig,Janet A. Johnston,Michael Gill,Brian A. Lawlor,Aoibhinn Lynch,Nick C. Fox,John Hardy,Roger L. Albin,Liana G. Apostolova,Liana G. Apostolova,Liana G. Apostolova,Steven E. Arnold,Sanjay Asthana,Craig S. Atwood,Clinton T. Baldwin,Lisa L. Barnes,Sandra Barral,Thomas G. Beach,James T. Becker,Eileen H. Bigio,Thomas D. Bird,Bradley F. Boeve,James Bowen,Adam L. Boxer,James R. Burke,Jeffrey M. Burns,Joseph D. Buxbaum,Nigel J. Cairns,Chuanhai Cao,Christopher S. Carlson,Cynthia M. Carlsson,Regina M. Carney,Minerva M. Carrasquillo,Steven L. Carroll,Carolina Ceballos Diaz,Helena C. Chui,David G. Clark,David G. Clark,David H. Cribbs,Elizabeth Crocco,Charles DeCarli,Malcolm B. Dick,Ranjan Duara,Denis A. Evans,Kelley Faber,Kenneth B. Fallon,David W. Fardo,Martin R. Farlow,Steven H. Ferris,Tatiana Foroud,Douglas Galasko,Marla Gearing,Daniel H. Geschwind,John R. Gilbert,Neill R. Graff-Radford,Robert C. Green,John H. Growdon,Ronald L. Hamilton,Lindy E. Harrell,Lawrence S. Honig,Matthew J. Huentelman,Christine M. Hulette,Bradley T. Hyman,Gail P. Jarvik,Erin L. Abner,Lee-Way Jin,Gyungah Jun,Anna Karydas,Jeffrey Kaye,Jeffrey Kaye,Ronald C. Kim,Neil W. Kowall,Joel H. Kramer,Frank M. LaFerla,James J. Lah,James B. Leverenz,Allan I. Levey,Ge Li,Andrew P. Lieberman,Kathryn L. Lunetta,Constantine G. Lyketsos,Daniel C. Marson,Frank Martiniuk,Deborah C. Mash,Eliezer Masliah,Wayne C. McCormick,Susan M. McCurry,Andrew McDavid,Ann C. McKee,M.-Marsel Mesulam,Bruce L. Miller,Carol A. Miller,Joshua W. Miller,Jill R. Murrell,Amanda J. Myers,Sid E. O'Bryant,John M Olichney,Vernon S. Pankratz,Joseph E. Parisi,Henry L. Paulson,William Perry,Elaine R. Peskind,Aimee Pierce,Wayne W. Poon,Huntington Potter,Joseph F. Quinn,Joseph F. Quinn,Ashok Raj,Murray A. Raskind,Barry Reisberg,Christiane Reitz,John M. Ringman,Erik D. Roberson,Ekaterina Rogaeva,Howard J. Rosen,Roger N. Rosenberg,Mark A. Sager,Andrew J. Saykin,Julie A. Schneider,Lon S. Schneider,William W. Seeley,Amanda Smith,Joshua A. Sonnen,Salvatore Spina,Robert S. Stern,Russell H. Swerdlow,Rudolph E. Tanzi,Tricia A. Thornton-Wells,John Q. Trojanowski,Juan C. Troncoso,Vivianna M. Van Deerlin,Linda J. Van Eldik,Harry V. Vinters,Jean Paul G. Vonsattel,Sandra Weintraub,Kathleen A. Welsh-Bohmer,Kirk C. Wilhelmsen,Jennifer Williamson,Thomas S. Wingo,Randall L. Woltjer,Clinton B. Wright,Chang En Yu,Lei Yu,Fabienne Garzia,Feroze Golamaully,Gislain Septier,Sebastien Engelborghs,Rik Vandenberghe,Peter Paul De Deyn,Carmen Muñoz Fernadez,Yoland Aladro Benito,Håkan Thonberg,Charlotte Forsell,Lena Lilius,Anne Kinhult-Ståhlbom,Lena Kilander,RoseMarie Brundin,Letizia Concari,Letizia Concari,Seppo Helisalmi,Anne M. Koivisto,Annakaisa Haapasalo,Vincent Dermecourt,Nathalie Fievet,Olivier Hanon,Carole Dufouil,Carole Dufouil,Alexis Brice,Alexis Brice,Karen Ritchie,Bruno Dubois,Bruno Dubois,Jayanadra J. Himali,C. Dirk Keene,JoAnn T. Tschanz,Annette L. Fitzpatrick,Walter A. Kukull,Maria C. Norton,Thor Aspelund,Eric B. Larson,Eric B. Larson,Ronald G. Munger,Jerome I. Rotter,Richard B. Lipton,María J. Bullido,María J. Bullido,Albert Hofman,Thomas J. Montine,Eliecer Coto,Eric Boerwinkle,Eric Boerwinkle,Ronald C. Petersen,Victoria Alvarez,Fernando Rivadeneira,Eric M. Reiman,Maura Gallo,Christopher J. O'Donnell,Joan S. Reisch,Amalia C. Bruni,Donald R. Royall,Martin Dichgans,Martin Dichgans,Mary Sano,Daniela Galimberti,Peter St George-Hyslop,Peter St George-Hyslop,Elio Scarpini,Debby W. Tsuang,Michelangelo Mancuso,Ubaldo Bonuccelli,Ashley R. Winslow,Antonio Daniele,Chuang Kuo Wu,Oliver Peters,Benedetta Nacmias,Matthias Riemenschneider,Reinhard Heun,Carol Brayne,David C. Rubinsztein,Jose Bras,Jose Bras,Rita Guerreiro,Rita Guerreiro,Ammar Al-Chalabi,Christopher Shaw,John Collinge,David G. Mann,David G. Mann,Jordi Clarimón,Rebecca Sussams,Simon Lovestone,Michael Conlon O'Donovan,Michael John Owen,Timothy W. Behrens,Simon Mead,André G. Uitterlinden,André G. Uitterlinden,Carlos Cruchaga,Martin Ingelsson,David A. Bennett,John Powell,Todd E. Golde,Caroline Graff,Philip L. De Jager,Kevin Morgan,Nilufer Ertekin-Taner,Onofre Combarros,Bruce M. Psaty,Peter Passmore,Steven G. Younkin,Claudine Berr,Vilmundur Gudnason,Dan Rujescu,Dennis W. Dickson,Jean-François Dartigues,Anita L. DeStefano,Anita L. DeStefano,Sara Ortega-Cubero,Hakon Hakonarson,Dominique Campion,Mercè Boada,John K Kauwe,Lindsay A. Farrer,Christine Van Broeckhoven,Christine Van Broeckhoven,M. Arfan Ikram,Lesley Jones,Jonathan L. Haines,Christophe Tzourio,Lenore J. Launer,Lenore J. Launer,Valentina Escott-Price,Richard Mayeux,Jean-François Deleuze,Najaf Amin,Alison Goate,Margaret A. Pericak-Vance,Peter Holmans,Cornelia M. van Duijn,Alfredo Ramirez,Alfredo Ramirez,Li-San Wang,Jean-Charles Lambert,Jean-Charles Lambert,Sudha Seshadri,Sudha Seshadri,Julie Williams,Gerard D. Schellenberg +487 more
TL;DR: Three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease are observed, providing additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's Disease.
Journal ArticleDOI
The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives.
TL;DR: The mitochondrial cascade hypothesis unequivocally states in sporadic, late-onset AD, mitochondrial function affects amyloid precursor protein (APP) expression, APP processing, or beta amyloids (Aβ) accumulation and argues if an amyloidal cascade truly exists, mitochondria function triggers it.
Journal ArticleDOI
The Alzheimer's Disease Mitochondrial Cascade Hypothesis
TL;DR: It is increasingly accepted by the AD research community that mitochondria play an important role in the late-onset forms of the disease, and the mitochondrial cascade hypothesis identifies alternative therapeutic targets.
Journal ArticleDOI
Cardiorespiratory fitness and brain atrophy in early Alzheimer disease
Jeffrey M. Burns,Benjamin Cronk,Heather Anderson,Joseph E. Donnelly,George Thomas,Amith Harsha,William Brooks,Russell H. Swerdlow +7 more
TL;DR: Increased cardiorespiratory fitness is associated with reduced brain atrophy in Alzheimer disease (AD) or a common underlying AD-related process may impact bothbrain atrophy and cardiorespiratory fitness.