Cancer chemoprevention activity of labdane diterpenes from rhizomes of Hedychium coronarium
Denise Coutinho Endringer,Francisca S.N. Taveira,Tamara P. Kondratyuk,John M. Pezzuto,Fernão Castro Braga +4 more
TLDR
Data support the potential chemopreventive activity of constituents from H. coronarium rhizomes in terms of inhibition of NF-κB, COX-1 and -2, the induction of antioxidant response element (ARE), and the inhibition of cell proliferation.Abstract:
Hedychium coronarium J. Koenig, Zingiberaceae, is a medicinal plant popularly used to treat inflammatory conditions in different countries. Three labdane diterpenes [isocoronarin D (1), methoxycoronarin D (2), ethoxycoronarin D (3)] and benzoyl eugenol (4) were isolated from rhizomes and their chemopreventive potential was evaluated using in vitro assays, namely the inhibition of NF-κB, COX-1 and -2, the induction of antioxidant response element (ARE), and the inhibition of cell proliferation. Diterpene 1 activated ARE (EC50 57.6 ± 2.4 µM), while 2, 3 and 4 significantly inhibited NF-κB (IC50 of 7.3 ± 0.3, 3.2 ± 0.3 and 32.5 ± 4.9 µM, respectively). In addition, 2 and 3 selectively inhibited COX-1 (IC50 values of 0.9 ± 0.0 and 3.8 ± 0.0 µM, respectively). These data support the potential chemopreventive activity of constituents from H. coronarium rhizomes.read more
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Therapeutic Potential of Essential Oils Focusing on Diterpenes.
Md. Torequl Islam,Md. Torequl Islam,Ana Maria Oliveira Ferreira da Mata,Rai Pablo Sousa de Aguiar,Márcia Fernanda Correia Jardim Paz,Marcus Vinícius Oliveira Barros de Alencar,Paulo Michel Pinheiro Ferreira,Ana Amélia de Carvalho Melo-Cavalcante +7 more
TL;DR: Diterpenes may be an immense featuring concern in pharmaceutical consumption from a drug discovery point of view and take into health‐consumption deportment.
Journal ArticleDOI
Diterpenes and Their Derivatives as Potential Anticancer Agents.
TL;DR: Diterpenes may be one of the lead molecules in the treatment of cancer, acting in the different pathways, and some are already under clinical trials, while others are in the nonclinical and/or pre‐clinical trials.
Journal ArticleDOI
Phytochemistry and pharmacology of ornamental gingers, Hedychium coronarium and Alpinia purpurata: a review
TL;DR: The phytochemistry and pharmacology of two ornamental gingers, Hedychium coronarium and Alpinia purpurata, are updated, and their botany and uses are described.
Journal ArticleDOI
Hedychium coronarium extract arrests cell cycle progression, induces apoptosis, and impairs migration and invasion in HeLa cervical cancer cells.
Asit Ray,Sudipta Jena,Biswabhusan Dash,Ambika Sahoo,Basudeba Kar,Jeetendranath Patnaik,Pratap Chandra Panda,Sanghamitra Nayak,Namita Mahapatra +8 more
TL;DR: The results indicate H. coronarium exerts antiproliferative and apoptotic effects against HeLa cells, and therefore may be used for treatment against cervical cancer.
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A review on traditional uses, phytochemistry and pharmacological activities of the genus Ballota.
TL;DR: The genus Ballota is a valuable source of bioactive compounds with therapeutic potential in different diseases, including promising antidepressant, anxiolytic, sedative-hypnotic, and antitussive activities in animal models.
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Triterpenoid CDDO-Me Blocks the NF-κB Pathway by Direct Inhibition of IKKβ on Cys-179
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