Journal ArticleDOI
Canine mesenchymal stem cells (MSCs): characterization in relation to donor age and adipose tissue‐harvesting site
Annalisa Guercio,Santina Di Bella,Stefania Casella,Patrizia Di Marco,Carmelo Russo,Giuseppe Piccione +5 more
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TLDR
It is found that the anatomical origin of the adipose tissue and the age of donors have effects only on the proliferative capacity of the MSCs, and cells show a progressive loss of the stemness characteristics with passages.About:
This article is published in Cell Biology International.The article was published on 2013-08-01. It has received 56 citations till now. The article focuses on the topics: Stem cell transplantation for articular cartilage repair & Clinical uses of mesenchymal stem cells.read more
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Adipose-Derived Mesenchymal Cells for Bone Regereneration: State of the Art
TL;DR: The aim of this review is to dissect the state of the art on ASC use in bone regenerative applications in the attempt to provide a comprehensive coverage of the topics, from the basic laboratory to recent clinical applications.
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Characterization and Immunomodulatory Effects of Canine Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stromal Cells
Keith A. Russell,Natalie H. C. Chow,David Dukoff,Thomas W.G. Gibson,Jonathan LaMarre,Dean H. Betts,Thomas Koch,Thomas Koch +7 more
TL;DR: Evaluated progenitor and non-progenitor functions as well as other characteristics of AT- and BM-MSC including proliferation rate, cell surface marker expression, DNA methylation levels, potential for trilineage differentiation towards osteogenic, adipogenic, and chondrogenic cell fates, and immunomodulatory potency in vitro.
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Stem cell technology for bone regeneration: current status and potential applications.
TL;DR: While continually expanding, the field of MSC-based bone tissue engineering and regeneration shows potential to become a clinical reality in the not-so-distant future.
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Use of Adipose-Derived Mesenchymal Stem Cells in Keratoconjunctivitis Sicca in a Canine Model
Antonio J. Villatoro,Viviana Fernández,Silvia Claros,Gustavo A. Rico-Llanos,José Becerra,José A. Andrades +5 more
TL;DR: This is the first time in literature that implantation of allogeneic Ad-MSCs around lacrimal glands has been found as an effective therapeutic alternative to treat dogs with KCS, and could reinforce a good effective solution to be extrapolated to future studies in human.
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In-vitro characterization of canine multipotent stromal cells isolated from synovium, bone marrow, and adipose tissue: a donor-matched comparative study
Robert N. Bearden,Shannon Huggins,Kevin J. Cummings,Roger Smith,Carl A. Gregory,W.B. Saunders +5 more
TL;DR: While cMSCs from synovium, marrow, and adipose tissue share a number of similarities, important differences in proliferation and trilineage differentiation exist and should be considered when selecting c MSCs for translational studies.
References
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Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
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Human Adipose Tissue Is a Source of Multipotent Stem Cells
Patricia A. Zuk,Min Zhu,Peter Ashjian,Daniel A. De Ugarte,Jerry I. Huang,Hiroshi Mizuno,Zeni Alfonso,John K. Fraser,Prosper Benhaim,Marc H. Hedrick +9 more
TL;DR: To confirm whether adipose tissue contains stem cells, the PLA population and multiple clonal isolates were analyzed using several molecular and biochemical approaches and PLA cells exhibited unique characteristics distinct from those seen in MSCs, including differences in CD marker profile and gene expression.
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Cold-activated brown adipose tissue in healthy men.
Wouter D. van Marken Lichtenbelt,Joost W. Vanhommerig,Nanda M Smulders,Jamie Drossaerts,Gerrit J. Kemerink,Nicole D. Bouvy,Patrick Schrauwen,G J Jaap Teule +7 more
TL;DR: Brown adipose tissue may be metabolically important in men, and the fact that it is reduced yet present in most overweight or obese subjects may make it a target for the treatment of obesity.
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Isolation of multipotent mesenchymal stem cells from umbilical cord blood.
TL;DR: Surprisingly, these cells were also able to differentiate into neuroglial- and hepatocyte-like cells under appropriate induction conditions and, thus, they may be more than mesenchymal stem cells as evidenced by their ability to differentiation into cell types of all 3 germ layers.
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Aging of mesenchymal stem cells
TL;DR: While the literature might often appear to conflict, many apparent discrepancies are attributable to inconsistent methods of extracting and isolating MSC which in fact contains various subsets of adult stem cells, varying not only in their differentiation potential but also in their vulnerability to senescence--ranging from quasi-somatic lifespan to perennial vigour.