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Capture agents and related methods and systems for detecting and/or sorting targets
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TLDR
In this paper, a target binding component, a scaffold component and an encoding component formed by standardized molecular units that can be coupled and decoupled in a controlled fashion are presented.Citations
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Methods of monitoring conditions by sequence analysis
Malek Faham,Thomas D. Willis +1 more
TL;DR: In this article, the authors used DNA sequencing to identify personalized biomarkers in patients with autoimmune disease and other conditions, which can be used to determine the disease state for a subject with an autoimmune disease or other condition.
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Combinatorial analysis and repair
Henrik Pedersen,Liselotte Brix +1 more
TL;DR: A method for the repair of a unit, by specific diagnosis of the undesired state, and its appropriate repair, using said specific diagnosis as a means to repair in an appropriate way said unit.
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Monitoring health and disease status using clonotype profiles
Malek Faham,Thomas D. Willis +1 more
TL;DR: In this article, a method for using DNA sequencing to identify personalized, or patient-specific biomarkers in patients with lymphoid neoplasms, autoimmune disease and other conditions is presented.
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Molecular vaccines for infectious disease
TL;DR: In this paper, a method for the construction of pharmamers is presented, where individual molecules of the construct can be bound to each other or the multimerization domain by covalent or non-covalent bonds, directly or via linkers.
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Methods and systems for processing polynucleotides
TL;DR: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing as discussed by the authors, which may be useful for a variety of applications, including POINTE sequencing.
References
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Journal ArticleDOI
Quantitative monitoring of gene expression patterns with a complementary DNA microarray.
TL;DR: A high-capacity system was developed to monitor the expression of many genes in parallel by means of simultaneous, two-color fluorescence hybridization, which enabled detection of rare transcripts in probe mixtures derived from 2 micrograms of total cellular messenger RNA.
Journal ArticleDOI
Phenotypic Analysis of Antigen-Specific T Lymphocytes
John D. Altman,Paul Moss,Philip J. R. Goulder,Dan H. Barouch,Michael G. McHeyzer-Williams,John I. Bell,Andrew J. McMichael,Mark M. Davis +7 more
TL;DR: Tetramers of human lymphocyte antigen A2 that were complexed with two different human immunodeficiency virus (HIV)-derived peptides or with a peptide derived from influenza A matrix protein bound to peptide-specific cytotoxic T cells in vitro and to T cells from the blood of HIV-infected individuals and correlated well with cytotoxicity assays.
Journal ArticleDOI
Printing proteins as microarrays for high-throughput function determination.
TL;DR: Miniaturized assays that accommodate extremely low sample volumes and enable the rapid, simultaneous processing of thousands of proteins are developed to facilitate subsequent studies of protein function.
Journal ArticleDOI
Cancer regression in patients after transfer of genetically engineered lymphocytes
Richard A. Morgan,Mark E. Dudley,John R. Wunderlich,Michael S. Hughes,James Chih-Hsin Yang,Richard M. Sherry,Richard E. Royal,Suzanne L. Topalian,Udai S. Kammula,Nicholas P. Restifo,Zhili Zheng,Azam V. Nahvi,Christiaan R. de Vries,Linda Rogers-Freezer,Sharon Mavroukakis,Steven A. Rosenberg +15 more
TL;DR: The ability to specifically confer tumor recognition by autologous lymphocytes from peripheral blood by using a retrovirus that encodes a T cell receptor is reported.