Journal ArticleDOI
Carbocycles from donor–acceptor cyclopropanes
TLDR
This review summarizes research directed towards the formation of carbocyclic adducts from donor-acceptor cyclopropanes and focuses on annulation and cycloaddition reactions mediated by Lewis or protic acid, bases, or thermal conditions.Abstract:
This review summarizes research directed towards the formation of carbocyclic adducts from donor–acceptor cyclopropanes. The focus of the review is on annulation and cycloaddition reactions (both inter- and intramolecularly) mediated by Lewis or protic acid, bases, or thermal conditions. Rearrangements resulting in carbocycles and those reactions mediated by transition metal catalysis have been excluded.read more
Citations
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In Situ Generation of Highly Reactive Allenes From Nitrocyclopropanes: Controllable Synthesis of Enynes and Enesters
Zhan-Yu Zhou,Zhong Yang Xu,Qiao-Yu Shen,Li Sha Huang,Xing Zhang,Ai-Bao Xia,Dan-Qian Xu,Zhen Yuan Xu +7 more
TL;DR: In this article, a ring-opening reaction of nitrocyclopropanes was developed for the first time for the divergent synthesis of enynes and enesters via in situ generated highly reactive electron-deficient intermediate allenes.
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Electricity mediated [3+2]-cycloaddition of N-sulfonylcyclopropanes with olefins via N-centered radical intermediates: access to cyclopentane analogs.
TL;DR: In this article , an external oxidant free electrochemical strategy was designed towards the β-scission of strained C-C bonds in cyclopropylamine, and the mechanistic studies ascertained that the methodology encompasses the N-center radical (NCRs) route and provides access to di- or tri-substituted cyclopentane analogs.
Journal ArticleDOI
Ring-Opening/Recyclization Cascades of Monoactivated Cyclopropanes.
TL;DR: During the course of the investigation, pronounced solvent, temperature, and substituent effects on the product distribution were discovered.
Journal ArticleDOI
AlCl3‐Promoted Ritter‐Type Ring‐Opening Reactions of γ‐Butyrolactone Fused Donor‐Acceptor Cyclopropanes with Wet Aliphatic Nitriles
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Stereospecific assembly of tetrahydroquinolines via tandem ring-opening/oxidative cyclization of donor-acceptor cyclopropanes with N-alkyl anilines.
TL;DR: An aerobic copper-catalyzed tandem reaction of N-alkyl anilines with donor-acceptor cyclopropanes is presented for the construction of tetrahydroquinolines via a sequential stereospecific ring opening and oxidative cyclization.
References
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Journal ArticleDOI
Telmisartan, Ramipril, or Both in Patients at High Risk for Vascular Events
Koon K. Teo,Janice Pogue,Leanne Dyal,Ingrid Copland,Helmut Schumacher,Gilles R. Dagenais,Craig S. Anderson +6 more
TL;DR: Telmisartan was equivalent to ramipril in patients with vascular disease or high-risk diabetes and was associated with less angioedema and a increased risk of hypotensive symptoms.
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Donor-acceptor-substituted cyclopropane derivatives and their application in organic synthesis.
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Journal ArticleDOI
Use of cyclopropanes and their derivatives in organic synthesis
Journal ArticleDOI
A new golden age for donor-acceptor cyclopropanes.
TL;DR: This Review highlights the appropriate tools for successfully employing donor-acceptor cyclopropanes in ring-opening reactions, cycloadditions, and rearrangements.
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