Journal ArticleDOI
Carbocycles from donor–acceptor cyclopropanes
TLDR
This review summarizes research directed towards the formation of carbocyclic adducts from donor-acceptor cyclopropanes and focuses on annulation and cycloaddition reactions mediated by Lewis or protic acid, bases, or thermal conditions.Abstract:
This review summarizes research directed towards the formation of carbocyclic adducts from donor–acceptor cyclopropanes. The focus of the review is on annulation and cycloaddition reactions (both inter- and intramolecularly) mediated by Lewis or protic acid, bases, or thermal conditions. Rearrangements resulting in carbocycles and those reactions mediated by transition metal catalysis have been excluded.read more
Citations
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Journal ArticleDOI
Stereoselective Synthesis of 4,5-Dihydroisoxazole Derivatives from 1,1-Dicyanocyclopropanes and Hydroxylamine Hydrochloride
Yue Zhang,Junhu Xin,Cunde Wang +2 more
Journal ArticleDOI
4‐(Dimethylamino)pyridinium Azide in Protic Ionic Liquid Media as a Stable Equivalent of Hydrazoic Acid
Ivan A. Andreev,Maksim A. Boichenko,Nina K. Ratmanova,Olga A. Ivanova,Irina M. Levina,Victor N. Khrustalev,Igor A. Sedov,Igor V. Trushkov +7 more
TL;DR: In this article , a multigram synthesis of 4-(dimethylamino)pyridinium azide, a stable, nonexplosive, low-hygroscopic source of azide ion soluble in both protic and aprotic organic solvents, was reported.
Journal ArticleDOI
Contributions of Ernest Wenkert to the Use of Cyclopropanes in Synthesis – Impact, Reflections, and Recollections
TL;DR: Ernst Wenkert's contributions to the chemistry of cyclopropanes and their use in synthesis are described in this article, where the impact of his work on the careers of others is addressed, along with reflections on his mentorship.
Journal ArticleDOI
Chemoselective and Diastereoselective Intramolecular (3+2) Cycloadditions of Epoxy and Aziridinyl Enolsilanes.
TL;DR: Computational studies indicate that the stepwise (3+2) cycloaddition involves an activated epoxy/aziridinyl intermediate and the conformational flexibility of the intermediate determines the preference for (3+) cycloadduct formation.
Journal ArticleDOI
Synthesis of Indole-Fused Dihydrothiopyrano Scaffolds via (3 + 3)-Annulations of Donor-Acceptor Cyclopropanes with Indoline-2-Thiones.
TL;DR: In this article , a new methodology for the synthesis of N-haloindole-fused dihydrothiopyrano derivatives via (3 + 3)-annulation of donor-acceptor cyclopropanes with indoline-2-thiones in the presence of Sc(OTf)3 as a Lewis acid catalyst has been developed.
References
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Telmisartan, Ramipril, or Both in Patients at High Risk for Vascular Events
Koon K. Teo,Janice Pogue,Leanne Dyal,Ingrid Copland,Helmut Schumacher,Gilles R. Dagenais,Craig S. Anderson +6 more
TL;DR: Telmisartan was equivalent to ramipril in patients with vascular disease or high-risk diabetes and was associated with less angioedema and a increased risk of hypotensive symptoms.
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Journal ArticleDOI
A new golden age for donor-acceptor cyclopropanes.
TL;DR: This Review highlights the appropriate tools for successfully employing donor-acceptor cyclopropanes in ring-opening reactions, cycloadditions, and rearrangements.
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