Journal ArticleDOI
Carbocycles from donor–acceptor cyclopropanes
TLDR
This review summarizes research directed towards the formation of carbocyclic adducts from donor-acceptor cyclopropanes and focuses on annulation and cycloaddition reactions mediated by Lewis or protic acid, bases, or thermal conditions.Abstract:
This review summarizes research directed towards the formation of carbocyclic adducts from donor–acceptor cyclopropanes. The focus of the review is on annulation and cycloaddition reactions (both inter- and intramolecularly) mediated by Lewis or protic acid, bases, or thermal conditions. Rearrangements resulting in carbocycles and those reactions mediated by transition metal catalysis have been excluded.read more
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Development of Synthetic Methodologies via Catalytic Enantioselective Synthesis of 3,3-Disubstituted Oxindoles
TL;DR: The phosphoramide-based bifunctional catalysts achieved better enantiofacial control than the analogous H-bond-donor-derived catalysts in these reactions, suggesting the potential of the former in new chiral catalyst development.
Journal ArticleDOI
Advances in Stereoconvergent Catalysis from 2005 to 2015: Transition-Metal-Mediated Stereoablative Reactions, Dynamic Kinetic Resolutions, and Dynamic Kinetic Asymmetric Transformations
TL;DR: This Review summarizes major advances in nonenzymatic, transition-metal-promoted dynamic asymmetric transformations reported between 2005 and 2015.
Journal ArticleDOI
Catalytic Enantioselective Ring-Opening Reactions of Cyclopropanes.
TL;DR: The development of enantioselective methods for the ring opening of cyclopropanes has grown from a proof of concept stage to a broad range of methods for accessing enantioenriched building blocks, and further extensive developments can be expected in the future.
Journal ArticleDOI
Cycloaddition reactions of enoldiazo compounds
TL;DR: This comprehensive review on cycloaddition reactions of enoldiazo compounds, with emphasis on methodology development, mechanistic insight, and catalyst-controlled chemodivergence, aims to provide inspiration for future discoveries in the field and to catalyze the application of enoldsiazo reagents by the wider synthetic community.
Journal ArticleDOI
Methodologies and Strategies for Selective Borylation of C–Het and C–C Bonds
Minyan Wang,Zhuangzhi Shi +1 more
TL;DR: A comprehensive overview of the direct borylation of less reactive C-Het and C-C bonds has become highly important to get efficiency and functional-group compatibility in organoborons.
References
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Journal ArticleDOI
Dynamic Kinetic Asymmetric [3 + 2] Annulation Reactions of Aminocyclopropanes
TL;DR: The first example of a dynamic kinetic asymmetric [3 + 2] annulation reaction of aminocyclopropanes with both enol ethers and aldehydes is reported, which gives access to important enantio-enriched nitrogen building blocks for the synthesis of bioactive compounds.
Journal ArticleDOI
Cyclopentannulation of 3-Alkylindoles: A Synthesis of a Tetracyclic Subunit of the Kopsane Alkaloids
TL;DR: The applicability of this methodology to the preparation of a key tetracyclic subunit of the kopsane alkaloids was demonstrated and significant regio- and diastereocontrol was observed.
Journal ArticleDOI
Polar Intramolecular Cross-Cycloadditions of Cyclopropanes toward Natural Product Synthesis
TL;DR: In this article, the acid-promoted intramolecular cycloadditions of activated cyclo-propanes were systematically described, and the potential of this strategy has been demonstrated by the synthesis of natural products.
Journal ArticleDOI
Zn(II)-Catalyzed synthesis of piperidines from propargyl amines and cyclopropanes.
TL;DR: The reaction of benzyl-protected propargyl amines and 1,1-cyclopropane diesters in the presence of catalytic Zn(NTf(2))(2) allows access to highly functionalized piperidines in excellent yields.
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