Journal ArticleDOI
Carbocycles from donor–acceptor cyclopropanes
TLDR
This review summarizes research directed towards the formation of carbocyclic adducts from donor-acceptor cyclopropanes and focuses on annulation and cycloaddition reactions mediated by Lewis or protic acid, bases, or thermal conditions.Abstract:
This review summarizes research directed towards the formation of carbocyclic adducts from donor–acceptor cyclopropanes. The focus of the review is on annulation and cycloaddition reactions (both inter- and intramolecularly) mediated by Lewis or protic acid, bases, or thermal conditions. Rearrangements resulting in carbocycles and those reactions mediated by transition metal catalysis have been excluded.read more
Citations
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"Cyclopropanation of Cyclopropanes": GaCl3-Mediated Ionic Cyclopropanation of Donor-Acceptor Cyclopropanes with Diazo Esters as a Route to Tetrasubstituted Activated Cyclopropanes.
I. A. Borisova,Daria-Maria V. Ratova,Konstantin V. Potapov,Anna V. Tarasova,Roman A. Novikov,Yury V. Tomilov +5 more
TL;DR: In this article, a new ionic cyclopropanation process involving the addition of diazo esters to donor-acceptor cyclopsanes (DAC) activated by GaCl3 has been developed.
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Recent advances on the synthesis of flavans, isoflavans, and neoflavans
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A Practical Method for the Synthesis of Donor-Acceptor Cyclobutanes by Cu(OAc)2 or FeCl3 Catalyzed [2+2] Cycloaddition
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Inherent Reactivity of Spiro-Activated Electrophilic Cyclopropanes
TL;DR: In this article, the second-order rate constants of the ring-opening reactions of thiophenolates with geminal bisacceptor-substituted cyclopropanes in DMSO at 20 °C were monitored by photometric methods.
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Synthesis of Octahydro- and Decahydroquinolines by a One-Pot Cascade Reaction of Tetrasubstituted Enecarbamate
TL;DR: A transition-metal-catalyzed cyclopropanation followed by ring opening was investigated for the synthesis of octahydroquinolines 4 and decahydrosine 5 having a quaternary carbon center at the angular position, which are core structures of the fawcettimine-type alkaloids.
References
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Journal ArticleDOI
Telmisartan, Ramipril, or Both in Patients at High Risk for Vascular Events
Koon K. Teo,Janice Pogue,Leanne Dyal,Ingrid Copland,Helmut Schumacher,Gilles R. Dagenais,Craig S. Anderson +6 more
TL;DR: Telmisartan was equivalent to ramipril in patients with vascular disease or high-risk diabetes and was associated with less angioedema and a increased risk of hypotensive symptoms.
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Donor-acceptor-substituted cyclopropane derivatives and their application in organic synthesis.
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Transition metal chemistry of cyclopropenes and cyclopropanes.
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Use of cyclopropanes and their derivatives in organic synthesis
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A new golden age for donor-acceptor cyclopropanes.
TL;DR: This Review highlights the appropriate tools for successfully employing donor-acceptor cyclopropanes in ring-opening reactions, cycloadditions, and rearrangements.
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