Journal ArticleDOI
Carbocycles from donor–acceptor cyclopropanes
TLDR
This review summarizes research directed towards the formation of carbocyclic adducts from donor-acceptor cyclopropanes and focuses on annulation and cycloaddition reactions mediated by Lewis or protic acid, bases, or thermal conditions.Abstract:
This review summarizes research directed towards the formation of carbocyclic adducts from donor–acceptor cyclopropanes. The focus of the review is on annulation and cycloaddition reactions (both inter- and intramolecularly) mediated by Lewis or protic acid, bases, or thermal conditions. Rearrangements resulting in carbocycles and those reactions mediated by transition metal catalysis have been excluded.read more
Citations
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Donor-acceptor bicyclopropyl configuration-fixed by an additional trimethylene bridge: synthesis and Lewis acid-catalyzed tandem three-membered rings opening
TL;DR: A diastereoselective synthesis of donor-acceptor bicyclopropyl, 8-phenyldispiro[2.3.2.0]-nonane-1,1-dicarboxylate, was carried out, which treated with Lewis acids acts as a synthetic equivalent of cis 1,6-zwitterionic intermediates as mentioned in this paper.
Journal ArticleDOI
Synthesis of 1,5-Substituted Pyrrolidin-2-ones from Donor–Acceptor Cyclopropanes and Anilines/Benzylamines
Maksim A. Boichenko,A. Yu. Plodukhin,Vitaly V. Shorokhov,Danyla S. Lebedev,Anastasya V. Filippova,S. S. Zhokhov,E. A. Tarasenko,Victor B. Rybakov,Igor V. Trushkov,Olga A. Ivanova +9 more
TL;DR: In this article , a straightforward synthetic route to pharmacologically important 1,5-substituted pyrrolidin-2-ones from donor-acceptor cyclopropanes bearing an ester group as one of the acceptor substituents was developed.
Journal ArticleDOI
Ring-opening 1,3-arylboration of arylcyclopropanes mediated by BCl3
TL;DR: A ring-opening 1,3-arylboration of aryl cyclopropanes using BCl3 in the presence of arene nucleophiles is reported.
Journal ArticleDOI
Synthesis of Fluoroalkyl Cyclopentenes: Highly Diastereoselective Phosphine‐Catalyzed [3+2] Annulation of β‐Fluoroalkylvinyl Arylsulfones with Morita‐Baylis‐Hillman Carbonates
TL;DR: In this article , a phosphine-catalyzed [3+2] annulation of β-fluoroalkylvinyl arylsulfones and Morita-Baylis-Hillman carbonates was achieved to generate tetrasubstituted cyclopentene carboxylates with a fluoro-alkylated stereogenic center at C4.
Journal ArticleDOI
A Nazarov-Ene Tandem Reaction for the Stereoselective Construction of Spiro Compounds.
TL;DR: In this article, an unprecedented Nazarov cyclization tandem reaction is presented, terminating the oxyallyl cation by an ene-type reaction, and leading stereoselectively to bicyclic spiro compounds.
References
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Journal ArticleDOI
Telmisartan, Ramipril, or Both in Patients at High Risk for Vascular Events
Koon K. Teo,Janice Pogue,Leanne Dyal,Ingrid Copland,Helmut Schumacher,Gilles R. Dagenais,Craig S. Anderson +6 more
TL;DR: Telmisartan was equivalent to ramipril in patients with vascular disease or high-risk diabetes and was associated with less angioedema and a increased risk of hypotensive symptoms.
Journal ArticleDOI
Donor-acceptor-substituted cyclopropane derivatives and their application in organic synthesis.
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Transition metal chemistry of cyclopropenes and cyclopropanes.
Journal ArticleDOI
Use of cyclopropanes and their derivatives in organic synthesis
Journal ArticleDOI
A new golden age for donor-acceptor cyclopropanes.
TL;DR: This Review highlights the appropriate tools for successfully employing donor-acceptor cyclopropanes in ring-opening reactions, cycloadditions, and rearrangements.
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